Oxidative Stress and Antioxidant Status in Patients with Bell’s Palsy

Terzi, Suat; Dursun, Engin; Yılmaz, Adnan; Çoşkun, Zerrin Özergin; Özgür, Abdulkadir; Çeliker, Metin; Demirci, Münir

doi:10.1515/jomb-2016-0033

Cited by 12 publications

(15 citation statements)

References 20 publications

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“…The cumulative effects of high concentrations of NO 2 might contribute to the increased risk of Bell's palsy. It was reported that patients with Bell's palsy had higher levels of oxidative stress and antioxidant activity than patients in the control group [15][16][17] . Patients with Bell's palsy had increased blood levels of thiol and disulfide activity levels compared to control participants 16 .…”

Section: Discussionmentioning

confidence: 99%

Air pollution by NO2 is associated with the risk of Bell’s palsy: A nested case-controlled study

Kim

Min

Choi

et al. 2020

Sci Rep

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this study investigated the relationship of weather and air pollution with the onset of Bell's palsy. the Korean Health insurance Review and Assessment Service-national Sample cohort (HiRA-nSc) data from 2002 through 2013 were used. The 3,935 Bell's palsy patients were matched with 15,740 control participants. the meteorological data, including daily mean temperature (°c), daily mean highest temperature (°C), daily mean lowest temperature (°C), daily mean temperature difference (°C), relative humidity (%), spot atmospheric pressure (hpa), sulfur dioxide (So 2) (ppm), nitrogen dioxide (no 2) (ppm), ozone (o 3) (ppm), carbon monoxide (co) (ppm), and pM 10 (particulate matter ≤ 10 μg/m 3) for 60 days, 30 days, 14 days, 7 days, and 3 days prior to the index date were analyzed for Bell's palsy cases and controls. conditional logistic regression analysis was used to estimate the odds ratios (oRs) of the association between the meteorological data and Bell's palsy. the mean no 2 and pM 10 concentrations for 60 days were higher, while that of O 3 was lower in the Bell's palsy group than in the control group (both p < 0.001). The Bell's palsy group showed 16.63-fold higher odds of NO 2 for 60 days (0.1 ppm) than the control group (95% CI = 10.18-27.16, P < 0.001). The ORs of PM 10 , and o 3 for 60 days showed inconsistent results according to the included variables. Bell's palsy was related to high concentrations of no 2 .

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Section: Discussionmentioning

confidence: 99%

Air pollution by NO2 is associated with the risk of Bell’s palsy: A nested case-controlled study

Kim

Min

Choi

et al. 2020

Sci Rep

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“…On the other hand; anti-oxidant molecules preserve neural growth and morphology by counteracting deleterious effects of free oxygen radicals. In a very recent study, Terzi et al (20) reported that serum total oxidant status, and oxidative stress index were significantly higher in patients with Bell's palsy compared with the control group that may be suggested to play a role in etiopathogenesis. We also determined serum CAT and ARES levels were remarkably lower and TOS levels were higher in PFP group compared with the control cases defining an imbalance between oxidant-antioxidant molecules.…”

Section: Discussionmentioning

confidence: 99%

Thiol/Disulphide homeostasis and oxidative stress in patients with peripheral facial paralysis

Demir¹,

Bozan²,

Koçak³

et al. 2018

Eastern J Med

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Facial paralysis is a widespread clinical disorder of the facial nerve that can cause distress (1). Peripheral facial paralysis (PFP) is the acute onset lower motor neuron palsy which is associated with remarkable functional and cosmetic morbidities (2, 3). The underlying etiology of this benign neurological disorder which presents as a mononeuritis is vague (4). Idiopathic PFP is the most common presentation of facial paralysis that constitutes for 60-75% of cases with acute, unilateral facial paralysis (5). The main pathophysiological mechanism responsible from the PFP is the ischemia, inflammation and swelling of the facial nerve (1, 6). It was shown that edema leading to the disturbance of microcirculation and the resultant ischemic process was associated with arteriolar spasm and thrombosis of the facial nerve within the facial canal (7). Although usually self-limited, PFP may lead to significant temporary oral incompetence and potential eye injuries due to the failure of closure of the eyelid. Additional long-term poor outcomes may be devastating for the patient. In that aspect; prompt treatment to improve facial functions and to enhance recovery is essential (8). Oxidative stress is defined as the imbalance between pro-oxidant and antioxidant molecules; and consequently reactive oxygen species (ROS) may accumulate as a result of ischemic events. The reactive oxygen species are associated with the impaired cellular metabolism causing lipid peroxidation, nucleic acid damage and modification of proteins (9, 10). Oxidation of-SH (sulfhydryl) groups in amino acids is the initial sign of protein oxidation. Thiols are functional sulfhydryl groups and oxidation of thiol groups leads to the formation of disulphide bonds. These disulphide bonds are reduced to thiol groups when oxidative stress is diminished. In recent

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Section: Introductionmentioning

confidence: 99%

“…The etiology of this condition remains unclear [3][4][5]. However, some aspects are considered possible triggers, such as genetic factors, viral infection, autoimmune disease, diabetes mellitus, pregnancy, Lyme disease, emotional factors, and stress [2,3,5,6]. Moreover, recent studies point to the reactivation of herpes simplex virus and/or herpes zoster (shingles) as possible triggers for the onset of paralysis [3,5,7].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have been conducted to predict the prognosis and quantify the degree of impairment in Bell's palsy [5,20]. Although the prognosis is good, with complete or adequate recovery in 70 to 85% of cases [1,3], shortening the recovery time is a common concern for both affected individuals and the health professionals in charge of treating this condition.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Complete and Fast Recovery from Idiopathic Facial Paralysis Using Laser-Photobiomodulation

Tanganeli

Oliveira

Silva

et al. 2020

Case Reports in Dentistry

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Idiopathic facial paralysis, also known as Bell’s palsy, exerts a negative effect on the quality of life. Although the prognosis is good in the majority of cases, a significant percentage of affected individuals may have sequelae that can negatively affect their lives. The use of therapeutic measures as early as possible can improve the prognosis. This article describes the successful use of laser-photobiomodulation as a single therapy in a patient with Bell’s palsy and confirms the possibility of using this therapeutic modality as a good choice, since it is a therapy that is painless, comfortable, and without systemic side effects. The findings demonstrate that the adequate use of laser-photobiomodulation can be an effective therapeutic option for patients with Bell’s palsy, regardless of the age, shortening the recovery time obtained with conventional therapies and avoiding sequelae. Further studies are needed for the establishment of adequate protocols.

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Oxidative Stress and Antioxidant Status in Patients with Bell’s Palsy

Cited by 12 publications

References 20 publications

Air pollution by NO2 is associated with the risk of Bell’s palsy: A nested case-controlled study

Air pollution by NO2 is associated with the risk of Bell’s palsy: A nested case-controlled study

Thiol/Disulphide homeostasis and oxidative stress in patients with peripheral facial paralysis

Complete and Fast Recovery from Idiopathic Facial Paralysis Using Laser-Photobiomodulation

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