Oxidative Stress and Antioxidant Status in Nigerian E-waste Workers: A Cancer Risk Predictive Study

Igharo, Godwin Osaretin; Anetor, John I.; Osibanjo, Oladele; Osadolor, Humphrey B.; David, M; Agu, Kingsley Chukwunonso

doi:10.9734/bjmmr/2016/22770

Cited by 9 publications

(8 citation statements)

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“…GPx is a selenium dependent enzyme with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water [37]. Significant reduction in SOD, CAT and GPx activity might be an indication of accumulation of H 2 O 2 that required to mump up these reactive species.…”

Section: Discussionmentioning

confidence: 99%

“…Glutathione had been reported to play a key role in maintaining proper function and preventing oxidative stress in human cells. Reduced glutathione reduces the oxidized form of the enzyme glutathione peroxidase, which in turn reduces hydrogen peroxide (H 2 O 2 ) dangerously reactive species within the cell [37]. Significant reduction in plasma levels of reduced glutathione (GSH) and TAS are thus a result of overwhelming antioxidant effects to reduce free radicals generated.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Atere¹,

Osadolor²

2017

Am. J. Biomed. Sci.

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Indiscriminate use of pesticides appears to increase the production of free radicals in organisms such as humans and other animals. Thus, the aim of this study was to investigate the effect of pyrethroid insecticides on oxidative stress biomarkers and atherogenic indices in exposed adult Wistar rats. A total number of apparently healthy 60 Wistar rats were randomly selected for this study and divided into two groups. Thirty six (36) were exposed to 1.2 % w/v pyrethroid insecticides while the remaining twenty four (24) were grouped as non-exposed. The animals in each group were anesthetized and blood sample was collected from the inferior vena cava after days of exposure. Plasma levels of total antioxidant status (TAS), malondialdehyde (MDA), glutathione (GSH), hydrogen peroxide (H 2 O 2 ), Nitric Oxide (NO) and lipids profiles were determined using standard spectrophotometric techniques. Plasma activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) were determined using standard spectrophotometric techniques. Statistical analysis of data was obtained and P<0.05 was considered significant. The mean TChol and HDL were significantly higher in 7days than 41days exposure, while plasma mean TChol and HDL were significantly lower in 41days than 21days exposure. The plasma mean levels of SOD, GPx, CAT, GSH and TAS were significantly decreasing while plasma mean levels of MDA, H 2 O 2 and NO were significantly increasing from 7 days through 41 days exposure in exposed groups irrespective of the gender. In conclusion, this study observed that there is oxidative stress in Wistar rats exposed to pyrethroids based insecticides and lowered antioxidant defenses also observed in the studied population. Also, there was increased in weight differences with possibility of becoming obese. Thus, antioxidant supplements are advised as a prophylactic supportive therapy for adequate measures in preventing development of oxidative stress-associated complications among exposed individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Atere¹,

Osadolor²

2017

Am. J. Biomed. Sci.

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“…45 The evidence suggests an association between WEEE exposure and changes in thyroid function, in cellular function and expression, in temperament and behaviour and in adverse neonatal outcomes. 33,37,46,47,48,49 Despite the volumes of WEEE recycled informally, the prevalence of work-related injuries among WEEE workers in Africa is largely unknown. A study assessed for the first time the prevalence, patterns and factors associated with occupational injuries among WEEE workers in the informal sector in Nigeria and symbolic of the African continent.…”

Section: Health Impactsmentioning

confidence: 99%

Management of Electronic Waste in Africa

Bates

Osibanjo

2019

Electronic Waste Management

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The issue of WEEE (usually called e-waste) is of growing concern across the whole of Africa. Increases in the use of personal computers, mobile phones and other electrical and electronic equipment has caused a subsequent rise in the disposal of end of life products in a continent where infrastructure for the environmentally sound treatment is scarce. This chapter reviews the current situation across the continent of Africa investigating the impacts of the rise in WEEE. The issue of illegal importation and the demand for second hand items is considered. Data for Nigeria, Kenya and South Africa are considered as these countries are all taking concrete steps to address and embed environmentally sound management of WEEE in their legislation and practices. A number of legislative drivers such as the Basel and Bamako Conventions are outlined as these are key drivers for reducing the import and impacts of WEEE in Africa. It is widely acknowledged, in a number of studies, that improper management of WEEE has serious health and environmental impacts. The deleterious effects on people working in the sector are described along with the deterioration in the environment and potential long term concerns if current practices are not improved. The scale of the problem is not to be underestimated but there is hope for the future, with a range of initiatives and projects bringing about change. A number of potential solutions are described such as Best of Two Worlds, an OEM (Original Equipment Manufacturer) model for the future and industrial recycling solutions. Finally, concrete recommendations for the widespread adoption of environmentally sound management of WEEE across Africa are provided.

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“…Studies have shown a direct impact of crude and backyard recycling of e-waste on workers in Nigeria (Igharo et al, 2014;Igharo et al, 2015aIgharo et al, , 2015bIgharo et al, 2016); Ghana (Nukpezah et al, 2014;Asante et al, 2012;Caravanos et al, 2011); China (Chan et al, 2007;Zhao et al, 2008;Huo et al, 2008;Huo et al, 2007;Wang et al, 2009;Zheng et al, 2008); and India (Steiner,, 2004;Ha et al, 2009;Eguchi et al, 2012). Also, on plant (roots of onion bulbs) (Bakare et al, 2012;Bakare et al, 2013;Olafisoye et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Distribution and potential risk of metals and metalloids in soil of informal E-waste recycling sites in Lagos, Nigeria

Adeyi¹,

Olayanju²,

Fatade³

2020

Ife Journal of Science

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Oxidative Stress and Antioxidant Status in Nigerian E-waste Workers: A Cancer Risk Predictive Study

Cited by 9 publications

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Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

Management of Electronic Waste in Africa

Distribution and potential risk of metals and metalloids in soil of informal E-waste recycling sites in Lagos, Nigeria

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