Oxidative stress and antioxidant defenses in mild cognitive impairment: a systematic review and meta-analysis

Nantachai, Gallayaporn; Maes, Michaël; Tunvirachaisakul, Chavit; Solmi, Marco; Maes, Michaël

doi:10.1101/2021.11.22.21266698

Cited by 3 publications

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References 104 publications

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“…The latter findings are further underscored by recent findings that aMCI is characterized by increased oxidative stress and lowered antioxidant defences (Nantachai et al, 2022).…”

Section: Discussionmentioning

confidence: 86%

Cognitive features of amnestic Mild Cognitive Impairment using specific Cambridge Neuropsychological Test Automated Battery test scores

Tran-Chi

Amrapala

Nantachai

et al. 2022

Preprint

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In older adults with amnestic Mild Cognitive Impairment (aMCI), the Cambridge Neuropsychological Test Automated Battery (CANTAB) probes indicated cognitive impairments most frequently in memory. This study aimed to investigate a) the cognitive features of aMCI using memory CANTAB tests and b) whether the clinical diagnosis of aMCI can be externally validated by these CANTAB measurements. We tested CANTAB tests that are specific to aMCI on 65 healthy controls and 66 people with aMCI who were diagnosed using Petersen`s criteria. These tests were spatial working memory (SWM), visual pattern recognition memory (PRM), delayed matching to sample (DSM), spatial span (SSP), and rapid visual information processing (RVP). The key aMCI features are impairments in PRM and DSM, whilst deficits in SSP and RVP are other, albeit somewhat less important features of aMCI. Nevertheless, neural network analyses including 10 CANTAB domains specific for MCI showed that only 70.8 percent of all subjects were properly identified with a sensitivity of 77.3%, specificity of 65.4% and an area under the ROC curve of 0.760. K-means cluster analysis using the same specific CANTAB test scores discovered 2 clusters with an adequate silhouette measure of cohesion and separation including a cluster with 36 subjects showing impairments in most neurocognitive tests. Deficits in spatial working, pattern recognition and visuospatial working memory as well as rapid visual information processing are key features of aMCI. Nevertheless, the clinical diagnosis of aMCI according to Petersen`s criteria is overinclusive because too many healthy controls are allocated to this group.

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“…The latter findings are further underscored by recent findings that aMCI is characterized by increased oxidative stress and lowered antioxidant defences (Nantachai et al, 2022).…”

Section: Discussionmentioning

confidence: 86%

Cognitive features of amnestic Mild Cognitive Impairment using specific Cambridge Neuropsychological Test Automated Battery test scores

Tran-Chi

Amrapala

Nantachai

et al. 2022

Preprint

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The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments

et al. 2022

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The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum and plasma compartments

Almulla

Maes

Tunvirachaisakul

et al. 2021

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The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be induced by inflammatory and oxidative stress mediators. This systematic review searched PubMed, Web of Science, and Google Scholar for papers published from inception until August 2021 and meta-analyzed the association between SCZ and TRYCATs in the central nervous system (CNS) and peripheral blood. We included 61 studies comprising 2813 patients and 2948 healthy controls. In the CNS we found a significant (p<0.001) increase in the kynurenine/tryptophan (KYN/TRP) (standardized mean difference, SMD=0.769, 95% confidence interval, CI: 0.456; 1.082) and kynurenic acid (KA)/KYN+TRP (SMD=0.697, CI:0.478-0.917) ratios, KA (SMD=0.646, CI: 0.422; 0.909) and KYN (SMD=1.238; CI: 0.590; 1.886), while the 3OH-kynurenine (3HK) + KYN-3-monooxygenase (KMO)/KYN ratio was significantly reduced (SMD=-1.089, CI: -1.682; -0.496). There were significant differences between KYN/TRP, (KYN+KA)/TRP, (3HK+KMO)/KYN, KA, and KYN levels among the CNS and peripheral blood, and among serum and plasma KYN. The only useful peripheral marker of CNS TRYCATs findings was the increased KYN/TRP ratio in serum (SMD=0.211, CI: 0.056; 0.366, p=0.007), but not in plasma. There was no significant increase in a neurotoxic composite score based on KYN, 3HK, and picolinic, xanthurenic, and quinolinic acid. SCZ is accompanied by increased IDO activity in the CNS and serum, and reduced KMO activity and a shift towards KA production in the CNS. This CNS TRYCATs profile indicates neuroprotective, negative immunoregulatory and anti-inflammatory effects. Peripheral blood levels of TRYCATs are dissociated from CNS findings except for a modest increase in serum IDO activity.

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Oxidative stress and antioxidant defenses in mild cognitive impairment: a systematic review and meta-analysis

Cited by 3 publications

References 104 publications

Cognitive features of amnestic Mild Cognitive Impairment using specific Cambridge Neuropsychological Test Automated Battery test scores

Cognitive features of amnestic Mild Cognitive Impairment using specific Cambridge Neuropsychological Test Automated Battery test scores

The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments

The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum and plasma compartments

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