Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis

Başkol, Gülden; Başkol, Mevlüt; Koçer, Derya

doi:10.1016/j.clinbiochem.2007.02.006

Cited by 104 publications

(75 citation statements)

References 32 publications

(39 reference statements)

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“…SOD activity and MDA level can reflect the degree of lipid peroxidation and oxidative stress. It was reported that NASH is closely related to lipid peroxidation and oxidative stress [25][26][27] . In the present study, we successfully established the NASH model by giving fat-rich diet, and observed the change of intestinal mucosa barrier function in simple fatty liver disease and NASH.…”

Section: Discussionmentioning

confidence: 99%

“…The pathogenesis of NASH remains unclear. Nowadays, lipid metabolism abnormality, insulin resistance and oxidative stress and lipid peroxidation reaction [4][5][6][7][8] are thought to play an important role in the pathogenesis of NASH [9,10] . It was reported that the change of intestinal environment may play a role in NASH, which may be a cause of enterogenous endotoxemia [11,12] .…”

Section: Introductionmentioning

confidence: 99%

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Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats

Sheng¹,

Wu²,

He³

et al. 2008

WJG

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AIM:To explore the change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis (NASH) in rats. METHODS: Thirty-two Sprague-Dawley (SD) rats were randomly divided into control group and model group. Rats in the control group were given normal diet, and rats in the model group were given fat-rich diet. Eight rats in each group were killed at end of the 8th and 12th wk, respectively. The levels of endotoxin, D-xylose, TG, TC, ALT and AST, intestinal tissue SOD and MDA as well as intestinal mucus secretory IgA (sIgA) were measured. The pathology of liver was observed by HE staining. RESULTS: At end of the 8th wk, there was no marked difference in the levels of endotoxin, D-xylose and sIgA between the two groups. At end of the 12th wk, rats in the model group developed steatohepatitis and had a higher serum level of endotoxin (P = 0.01) and D-xylose (P = 0.00) and a lower serum level of sIgA (P = 0.007). CONCLUSION: Intestinal mucosa barrier malfunction may exist in NASH rats and may be an important promoter of NASH in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats

Sheng¹,

Wu²,

He³

et al. 2008

WJG

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“…This implies that there is continuous inflammation remaining in the liver, such as chronic cytoinfiltration of Glisson's capsules, which are identified in biopsied specimens of the liver in the postoperative patients with BA. Baskol et al [1] reported that oxidative stress contributes to the pathology of adult NASH. The excessive production of active oxygen or radicals is thought to be a worsening factor [1].…”

Section: Introductionmentioning

confidence: 98%

Oxidative stress profile in the post-operative patients with biliary atresia

et al. 2008

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“…We also previously studied different antioxidant enzymes separately and we found decreased antioxidant enzymes activities in patients with NASH (26). However, the measurement of different antioxidant molecules separately was not only impractical but also held no clinical significance.…”

Section: Başkol Et Al Aopp Total Thiol Tos Tas In Nashmentioning

confidence: 99%

Advanced oxidation protein products, total thiol levels and total oxidant/antioxidant status in patients with nash

Başkol

Seçkin²,

Başkol³

2015

Turk J Gastroenterol

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Background/Aims: In this study we aim to evaluate the relationship of advanced oxidation protein products (AOPP), total thiol, total antioxidant status (TAS), total oxidant status (TOS) levels and oxidative stress index (OSI) in patients with nonalcoholic steatohepatitis (NASH). Materials and Methods: A total of 28 patients with NASH and 19 age-and-gender-matched healthy subjects were enrolled in the study as control group. Plasma AOPP and thiol levels were determined by spectrophotometric methods. Plasma TAS and TOS levels were measured using commercially available kits and OSI was calculated. Results: Plasma AOPP (256.7 vs. 125.8 μmol/L) and TOS levels (8.9 vs. 5.9 μmol H2O2 equiv/L) were higher in patients with NASH than the controls (p<0.019 and p<0.041 respectively). Plasma total thiol levels (235.0 vs. 291.6 μmol/L) were lower in patients with NASH than the controls (p<0.001). TAS levels (1.14 vs. 1.14 mmol Trolox equiv/L) were not significantly different in patients with NASH than the controls (p>0.900). OSI values (8.0 vs. 5.5) were higher in patients with NASH than the controls (p<0.039). Conclusion: Our findings indicate that oxidative stress increases in patients with NASH as shown by increases in TOS level. We think effective antioxidant therapy to inhibit protein oxidation and also to increase of TAS and total thiol levels may be a therapeutic option in patients with NASH who have under increased oxidative stress.

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Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis

Cited by 104 publications

References 32 publications

Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats

Change of intestinal mucosa barrier function in the progress of non-alcoholic steatohepatitis in rats

Oxidative stress profile in the post-operative patients with biliary atresia

Advanced oxidation protein products, total thiol levels and total oxidant/antioxidant status in patients with nash

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