Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study

Abstract

OBJECTIVE: Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies against putative periodontopathic bacteria and their association with periodontal conditions, in a community-based study. SUBJECTS AND METHODS: Serum samples were measured for reactive oxygen metabolite (ROM) levels and anti-oxidant capacity. The serum levels of immunoglobulin G (IgG) antibodies to Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), and Eikenella corrodens (Ec) were determined by ELISA. RESULTS: The participants with greater clinical attachment loss had higher serum ROM levels and IgG antibody titers to Pg. Serum ROM levels were positively correlated with antibody titers to Pg, Pi, and Ec. When the participants with greater probing pocket depth and clinical attachment loss were used as the dependent variables, high ROM levels showed a statistically significant associations in multivariate logistic analyses; the adjusted odds ratios were 2.9 (95% confidence interval = 1.0-8.5) and 6.0 (95% confidence interval = 2.0-17.6), respectively. CONCLUSIONS: It was concluded that an increased oxidative stress may be detrimental to periodontitis in Japanese community-dwelling adults. Oral Diseases (2014) 20, e49-e56

Periodontitis-activated monocytes/macrophages cause aortic inflammation

“…Clinical studies revealed that the severity of periodontitis positively correlated with serum oxidative stress3839. Although we did not measure oxidative stress or lipids profiles in our study, oxidative stress is known to induce the activation of monocytes/macrophages4041.…”

Prognostic Value of 8‐Hydroxy‐2′‐Deoxyguanosine and Human Neutrophil Elastase/α1‐Proteinase Inhibitor Complex as Salivary Biomarkers of Oxidative Stress in Chronic Periodontitis

“…ROS generation secondary to PMN infiltration, a wellknown host defense mechanism against bacterial invasion, 6,13,30,31 has been thoroughly implicated in the breakdown of periodontal tissues. 13 Characteristic markers including immunoglobulins, 32,33 8-OHdG, 8,[12][13][14][15][16][17]27,30,34,35 enzymes, 15,18,28,29,[35][36][37] and bacterial byproducts 11,38,39 have been described in diseased periodontal tissues, saliva, gingival crevicular fluid (GCF), and serum samples. Although the available information has demonstrated positive associations between the levels of 8-OHdG and HNE/a1-PI regarding CP, it is difficult to establish firm conclusions, because the number of studies concerning differences about these two biomarkers in saliva is too limited.…”

The therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway

“…Numerous studies have been implemented to reveal the underling mechanisms contributing to chronic periodontitis with DM (CPDM), in which oxidative stress has been suggested as an important pathogenic factor in this composite disease . Clinically, the immunoglobulin G antibodies to periodontitis‐related pathogens were positively correlated with the levels of serum reactive oxygen species (ROS) metabolites . Moreover, high‐glucose exposure could induce higher gingival oxidative stress, which enhanced alveolar bone resorption in CPDM .…”