Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents

Darvesh, Altaf S.; Carroll, Richard T.; Bishayee, Anupam; Geldenhuys, Werner J.; Schyf, Cornelis J. Van der

doi:10.1586/ern.10.42

Cited by 181 publications

(101 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emerging literature indicates that mechanisms of aging and Alzheimer's disease are linked and that these mechanisms can be modulated by both calorie restriction regimens and calorie restriction mimetics such as resveratrol [22,23]. However, emerging roles of resveratrol in neuronal protection has mainly been attributed to its effects as an antioxidant, and/or as a calorie restriction mimetic [22,24]. On the basis of the present findings we hypothesize that the inducing effects of resveratrol on the expression of neurotrophic factors may be an alternative explanation for the neuroprotective role of this compound and possibly for its therapeutic value in neuronal protection.…”

Section: Resultsmentioning

confidence: 99%

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

et al. 2011

View full text Add to dashboard Cite

Resveratrol is a plant polyphenolic compound. Evidence indicates that resveratrol has beneficial effects against aging and neurodegenerative diseases. The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF) in the hippocampus of rat brain. Rats were administrated orally by different doses (2.5-20 mg/kg bwt) of resveratrol for 3, 10 and 30 days. Saline was used as control and 10% ethanol in saline was used as vehicle for resveratrol. Measurement of BDNF mRNA by Real-time RT-PCR showed that levels of the mRNA for BDNF were significantly and dose dependently elevated in the hippocampal tissues of rats. The findings suggest that the neuroprotective effects of resveratrol may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA.

show abstract

Section: Resultsmentioning

confidence: 99%

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Phytochemicals have shown potential usefulness as therapeutic, as well as chemopreventive, agents for several chronic disorders such as metabolic, neoplastic and neurodegenerative diseases (Darvesh et al, 2010). Dietary polyphenols, such as catechins present in green tea, curcumin in turmeric, lycopene found in tomatoes, resveratrol in peanuts and many others, have shown considerable promise as both preventive and therapeutic agents in cancer affecting several organ systems such as breast, liver, lung, prostate and skin (Ullah & Khan, 2008 ;Khan& Mukhtar, 2015).…”

Section: Introductionmentioning

confidence: 99%

Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy

Tork

Khaleel²,

Abdelmaqsoud³

2016

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Taken together these findings suggest a bidirectional inter-relation between Aβ and oxidative stress that may result in a vicious positive feedback pathway, and based on these evidences, a role for antioxidants in the prevention and/or treatment of AD has been hypothesized [90].…”

Section: Involvement Of Sam In Oxidative Stress and Neurodegenerationmentioning

confidence: 82%

Role of S-adenosylmethionine in the Modulation of Oxidative Stress- Related Neurodegeneration

Cavallaro¹,

Fuso²,

D’Erme³

et al. 2016

Int J Clin Nutr Diet

View full text Add to dashboard Cite

S-adenosyl-L-methionine (SAM) is the main biological methyl donor in transmethylation reactions, consisting in the transferring of a methyl moiety to different substrates including DNA, proteins, lipids and RNA. SAM level in the organism decreases with aging and restoring the original levels through exogenous supplementation is an important tool for the improvement of many vital functions. Indeed, SAM deficiency may contribute to the onset of several diseases, i.e. depression, liver diseases, osteoarthritis and senile neurological disorders such as Alzheimer's and Parkinson's diseases. Recent evidences indicate that SAM may have an involvement in oxidative stress, a process which typically involves an alteration of cellular sulfur amino acids homeostasis. SAM is not only the principal methyl donor, but also a precursor of glutathione, the major endogenous antioxidant, whose role in counteracting oxidative stress is well known. In this review we will highlight the role of SAM not just as a methyl-donor but also as a regulator of different metabolic pathways involved in the antioxidant response in brain related disorders. Role of S-adenosylmethionine in the Modulation of Oxidative StressRelated Neurodegeneration Review ArticleOpen Access IntroductionThe interaction between environmental and genetic factors plays a fundamental role in inducing and modulating the aging processes towards brain disorders. Among environmental factors, diet and nutritional lifestyle have a key role in brain health through the alteration of the intake or the bioavailability of metabolites and cofactors. Specific nutritional factors have particular impact on one-carbon metabolism, which is a complex biochemical pathway regulated by the presence of folate, vitamin B12 and B6 (among other metabolites) and leading to the production of S-adenosyl-L-methionine (SAM), the main biological methyl donor in transmethylation reactions, consisting in the transferring of a methyl moiety to different substrates including DNA, proteins, lipids and RNA. This metabolism involves three interrelated biochemical pathways: folate cycle, transsulfuration pathway and methionine cycle. These three metabolic sequences were first combined and correlated in 1964 by Laster's group [1][2][3] giving the integrated point of view of transmethylation and transsulfuration pathways, linking sulfur amino acid metabolism to the provision of methyl groups for many biochemical processes. Normal functioning of this metabolic cycle is essential for growth and development and impairment of this metabolism; transmethylation efficiency is associated with many diseases like cardiovascular diseases [4][5], liver diseases [6-9], neural tube defects [10] and brain diseases [11][12][13][14][15][16]. One-carbon metabolism alterations, low methylation and oxidative stress are all linked to Late Onset Alzheimer's Disease (LOAD) [17][18][19][20][21][22][23][24] Moreover, wide confirmed reports underline the role of SAM dependent reactions in age related neurodegeneration also showi...

show abstract

Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents

Cited by 181 publications

References 155 publications

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

Altered Cell to Cell Communication, Autophagy and Mitochondrial Dysfunction in a Model of Hepatocellular Carcinoma: Potential Protective Effects of Curcumin and Stem Cell Therapy

Role of S-adenosylmethionine in the Modulation of Oxidative Stress- Related Neurodegeneration

Contact Info

Product

Resources

About