Oxidative stress and age-related changes in T cells: is thalassemia a model of accelerated immune system aging?

Ghatrehsamani, Mahdi; Esmaeil, Nafiseh; Soleimani, Masoud; Asadi-Samani, Majid; Ghatreh‐Samani, Keihan; Shirzad, Hedayatollah

doi:10.5114/ceji.2015.56973

Cited by 32 publications

(33 citation statements)

References 125 publications

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“…Also, flavonoids, alkaloids, coumarins, carotenoids, and vitamins such as E, A, C (ascorbic acid), and D3 are some of the most important nonenzymatic antioxidants that are usually available in many natural products [24].…”

Section: Relation Between Ros Actions With Promoting and Fighting Cancermentioning

confidence: 99%

Antioxidants as a Double-Edged Sword in the Treatment of Cancer

Asadi-Samani¹,

Farkhad²,

Mahmoudian-Sani³

et al. 2019

Antioxidants

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Antioxidant compounds are thought to prevent and treat diseases, especially cancer, under any circumstances. For this purpose, nature-based antioxidants nowadays are being commonly used to prevent and treat diseases. Indeed, phenolic compounds found in medicinal plants have opened a new horizon to prevent and treat diseases because of having antioxidant properties. However, some recent studies have reported that antioxidants are not absolute anticancer compounds and certain drugs have been reported to reduce levels of reactive oxygen species (ROS) in the cancer cells, i.e., their main action mechanism. It has been argued that increasing levels of ROS cause an increase in apoptosis rate and therefore can be considered an approach to treat fatal and hard-to-treat cancers. This chapter seeks to partly explain the role of ROS in progression or inhibition of cancer growth in addition to the role of antioxidants in preventing and treating this disease.

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Section: Relation Between Ros Actions With Promoting and Fighting Cancermentioning

confidence: 99%

Antioxidants as a Double-Edged Sword in the Treatment of Cancer

Asadi-Samani¹,

Farkhad²,

Mahmoudian-Sani³

et al. 2019

Antioxidants

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“…3) through the reduction of TBX, which in turn may increase sensitization of colorectal cancer cells to chemotherapy such as NVP-BEZ235. Senescent cells are a population that do not proliferate anymore but induction of senescence cells increase sensitization to chemotherapy 24,25 . However, senescence cells was shown as a main culprit in tumor recurrence 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Although NVP-BEZ235 and XAV-939 have been shown a promising result in the treatment of colorectal cancer (CRC), our data is little with regard to the effect of environmental cytokine on this drugs. In order to explore the reaction of CRC to this novel therapy, the current study proposes to investigate the inhibitory effect of NVP-BEZ235 and/or XAV-939 in CRC cells in combination with TGF-β as a tumor environmental cytokine to analyze their effect on cancer cell proliferation, cell death and expression of cancer promoting genes. The cells were treated with single or combination of NVP-BEZ235, XAV-939 and TGF-β. Cell viability was evaluated by MTT assay. Flow cytometry method was used to determine cellular death. Real-time PCR was utilized to identify the effect of treatments on expression of snail, slug, C-myc and notch1 genes. The results revealed that NVP-BEZ235 inhibited CRC cells proliferation and induced senescence cells more than XAV-939. Although, XAV-939 increased cellular death and inhibited senescence induction of CRC cells better than NVP-BEZ235. TGF-β pretreatment sensitizes CRC cells to the cytotoxic effect of NVP-BEZ235 and XAV-939. Real-time PCR analysis showed that resistance cells to NVP-BEZ235 increased expression of slug. Expression of notch enhanced remarkably when cells treated with both NVP-BEZ235 and XAV-939. The results of the present study demonstrated that presence of anti-inflammatory cytokine like TGF-β augments the inhibitory effect of XAV-939 or especially NVP-BEZ235. INTRODUCTION: Colorectal cancer (CRC) is the third most common cancer and the fourthleading cause of cancer death worldwide 1. Although surgical resection and conventional therapy like chemotherapy are efficient at least in early, subsequent relapse and metastasis, as well as drug resistance frequently occurred 2. It is now apparent that tumor environmental cytokines such as TGF-β play a major role in colon tumor initiation as well as progression and metastasis 3, 4 .

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“…This can be attributed to the oxygen free radicals produced by CP (52), because CP can cause oxidative stress in addition to enzymatic and hormonal alterations (53). Antioxidants are able to inhibit oxygen free radicals, reduce oxidative stress, and minimize associated complications (54)(55)(56)(57)(58). The plants and plant-based compounds, presented in this review article, are highly useful to reduce oxidative stress.…”

Section: (34)mentioning

confidence: 99%