Oxidative Stress – A Major Player in the Pathophysiology of Systemic Lupus Erythematosus

Bhatnagar, Archana; Aggarwal, Apoorva

doi:10.1007/978-3-642-30018-9_98

Cited by 3 publications

(4 citation statements)

References 84 publications

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“…When ROS production exceeds the physiological antioxidant defense, oxidative stress occurs consequently leading to oxidative modification of proteins. This protein alteration may lead to the formation of neoepitopes resulting in the formation of autoantibodies [7,8]. The pathogenesis of autoimmune diseases (ADs) such as RA is characterized by the loss of peripheral tolerance to autoantigens, excessive activation of T and B cells, which leads to increased levels of cytokines and autoantibodies (rheumatoid factor, RF; anti-cyclic citrullinated peptide antibodies, ACPA; etc.)…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species (ROS) in the Pathophysiology of Rheumatoid Arthritis (RA)

Ahsan¹,

Hasan²,

Ahmad³

2022

Reactive Oxygen Species

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Free radicals are highly reactive molecules that are unstable and have extremely short-short half-life. They are derived from either oxygen (reactive oxygen species, ROS) or nitrogen (reactive nitrogen species, RNS) in mitochondria, plasma membrane and endoplasmic reticulum due to oxidative stress and damage. ROS/RNS are physiologically useful at low concentrations and are responsible for the activation of redox-sensitive signaling pathways, phagocytosis of infected cells and removal of abnormal and aging cells. The endogenous sources of ROS are the electron transport chain, the respiratory burst of phagocytes and oxidation of lipids. These radicals react with biomolecules such as DNA, proteins and lipids and may cause pathophysiological conditions such as autoimmunity, carcinogenesis, and neurodegenerative diseases. The role of ROS in autoimmune response remains complex and they have been implicated in the initiation, generation and amplification of novel epitopes. ROS also appears to play a critical role in rheumatoid arthritis (RA), a systemic autoimmune disease of the joints also known as inflammatory arthritis (IA). ROS are involved in the initiation of various signaling pathways and have a significant role in the pathophysiology of RA.

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Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species (ROS) in the Pathophysiology of Rheumatoid Arthritis (RA)

Ahsan¹,

Hasan²,

Ahmad³

2022

Reactive Oxygen Species

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“…This allows for normal oxidative metabolism to occur without damaging cells, as well as normal ROS-mediated cellular responses such as the destruction of infectious pathogens and intracellular signaling [ 16 ]. Oxidative stress occurs when the production of ROS overwhelms the antioxidant defense mechanisms, leading to cellular damage and inflammation [ 17 ]. Several methods have been developed to evaluate oxidant and antioxidant activities separately [ 18 19 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice

Ahmadi

Fathi

Moeini

et al. 2018

Clin Exp Reprod Med

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ObjectiveConcerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in ART-conceived babies. Findings regarding the health of ART-conceived babies are controversial. The present study was conducted to evaluate the prooxidant-antioxidant balance (PAB) in in vitro fertilization (IVF)-conceived mice in comparison to naturally conceived offspring.MethodsMice (6–8 weeks) were divided into two groups (IVF-conceived and naturally conceived) matched by sex, age, weight, and litter size. A 1-mL blood sample was taken and the sera were separated. The oxidant-antioxidant balance was evaluated using a fast and reliable PAB assay. The results were expressed as mean±standard deviation.ResultsThe mean PAB values (HK units) in the IVF-conceived and naturally conceived groups were 59.70±22.30 and 54.70±18.22, respectively (p=0.82).ConclusionSince free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured.

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“…These free radicals are deactivated by a chain reaction-breaking antioxidant defense system consisting of enzymes and numerous nonenzymatic antioxidants [ 7 ]. Oxidative stress is essentially an imbalance between productions of reactive oxygen species (ROS) and antioxidant defense mechanism [ 8 ]. The increased production of free radicals disrupts redox status and can increase the expression of a wide variety of inflammatory molecules that may be important causes of the inflammation and tissue damage [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The increased production of free radicals disrupts redox status and can increase the expression of a wide variety of inflammatory molecules that may be important causes of the inflammation and tissue damage [ 9 ]. Several studies suggested that oxidative stress could be a risk factor for autoimmune diseases such as SLE [ 8 – 10 ]. Impaired antioxidant status has been reported in the saliva of SLE patients too [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings

Jafari

Salimi

Nakhaee

et al. 2016

Autoimmune Diseases

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Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147.3 ± 42 versus 84.8 ± 32.2 HK, P < 0.0001). Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) (r = 0.492, P < 0.001). In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations. Conclusion. The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR. Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis. These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients.

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Oxidative Stress – A Major Player in the Pathophysiology of Systemic Lupus Erythematosus

Cited by 3 publications

References 84 publications

Reactive Oxygen Species (ROS) in the Pathophysiology of Rheumatoid Arthritis (RA)

Reactive Oxygen Species (ROS) in the Pathophysiology of Rheumatoid Arthritis (RA)

Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice

Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings

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