Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Singh, Anju; Kukreti, Ritushree; Saso, Luciano

doi:10.3390/molecules24081583

Cited by 1,486 publications

(1,059 citation statements)

References 143 publications

(138 reference statements)

Supporting

Mentioning

889

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, altered mitochondrial function and oxidative stress are well‐described pathophysiological mechanisms in neurodegenerative and autism spectrum disorders (for a review, see Ref. ). Thus, it is not surprising that the mitochondrial function also seems to be impaired in AS.…”

Section: Molecular Pathogenesis: the Contribution Of The Hippocampusmentioning

confidence: 99%

Angelman syndrome: a journey through the brain

et al. 2020

View full text Add to dashboard Cite

Angelman syndrome (AS) is an incurable neurodevelopmental disease caused by loss of function of the maternally inherited UBE3A gene. AS is characterized by a defined set of symptoms, namely severe developmental delay, speech impairment, uncontrolled laughter, and ataxia. Current understanding of the pathophysiology of AS relies mostly on studies using the murine model of the disease, although alternative models based on patient-derived stem cells are now emerging. Here, we summarize the literature of the last decade concerning the three major brain areas that have been the subject of study in the context of AS: hippocampus, cortex, and the cerebellum. Our comprehensive analysis highlights the major phenotypes ascribed to the different brain areas. Moreover, we also discuss the major drawbacks of current models and point out future directions for research in the context of AS, which will hopefully lead us to an effective treatment of this condition in humans.

show abstract

Section: Molecular Pathogenesis: the Contribution Of The Hippocampusmentioning

confidence: 99%

Angelman syndrome: a journey through the brain

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The common disease-common variant hypothesis proposes that the genes of common variants such as single nuclear polymorphisms, coding regulatory sequences, lead to susceptibility of complex polygenic diseases [155]. OS damages RNA to cause dysregulation of gene expression affecting inflammatory processes, the ubiquitin-proteasome system, energy production, cell-cycle regulation, and glutamate excitotoxicity [156]. Many proteins play an important part in the regulation of NDs.…”

Section: Variations On the Theme? Commonalities In Symptomatology Andmentioning

confidence: 99%

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Tanaka

Toldi

Vécsei

2020

IJMS

186

197

View full text Add to dashboard Cite

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor dysfunctions to psychobehavioral manifestations. A common clinical course is the proteinopathy-induced neural dysfunction leading to anatomically corresponding neuropathies. However, current diagnostic criteria based on pathology and symptomatology are of little value for the sake of disease prevention and drug development. Overviewing the pathomechanism of NDs, this review incorporates systematic reviews on inflammatory cytokines and tryptophan metabolites kynurenines (KYNs) of human samples, to present an inferential method to explore potential links behind NDs. The results revealed increases of pro-inflammatory cytokines and neurotoxic KYNs in NDs, increases of anti-inflammatory cytokines in AD, PD, Huntington’s disease (HD), Creutzfeldt–Jakob disease, and human immunodeficiency virus (HIV)-associated neurocognitive disorders, and decreases of neuromodulatory KYNs in AD, PD, and HD. The results reinforced a strong link between inflammation and neurotoxic KYNs, confirmed activation of adaptive immune response, and suggested a possible role in the decrease of neuromodulatory KYNs, all of which may contribute to the development of chronic low grade inflammation. Commonalities of multifactorial NDs were discussed to present a current limit of diagnostic criteria, a need for preclinical biomarkers, and an approach to search the initiation factors of NDs.

show abstract

“…ROS and RNS largely contribute to neuronal degeneration due to the induced alteration of macromolecules such as DNA, RNA, proteins and lipids [13].…”

Section: Oxidative Metabolism In Neurodegenerative Diseasesmentioning

confidence: 99%

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Oppedisano

Maiuolo

Gliozzi

et al. 2020

IJMS

View full text Add to dashboard Cite

The neurodegenerative process is characterized by the progressive ultrastructural alterations of selected classes of neurons accompanied by imbalanced cellular homeostasis, a process which culminates, in the later stages, in cell death and the loss of specific neurological functions. Apart from the neuronal cell impairment in selected areas of the central nervous system which characterizes many neurodegenerative diseases (e.g., Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, etc.), some alterations may be found in the early stages including gliosis and the misfolding or unfolding accumulation of proteins. On the other hand, several common pathophysiological mechanisms can be found early in the course of the disease including altered oxidative metabolism, the loss of cross-talk among the cellular organelles and increased neuroinflammation. Thus, antioxidant compounds have been suggested, in recent years, as a potential strategy for preventing or counteracting neuronal cell death and nutraceutical supplementation has been studied in approaching the early phases of neurodegenerative diseases. The present review will deal with the pathophysiological mechanisms underlying the early stages of the neurodegenerative process. In addition, the potential of nutraceutical supplementation in counteracting these diseases will be assessed.

show abstract

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Cited by 1,486 publications

References 143 publications

Angelman syndrome: a journey through the brain

Angelman syndrome: a journey through the brain

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Contact Info

Product

Resources

About