Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine

Федорова, Т. Н.; Devyatov, A. A.; Berezhnoi, D. S.; Stvolinskii, S. L.; Morozova, Maria P.; Гаврилова, С.А.; Tutelyan, V A

doi:10.1007/s10517-018-4256-x

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…In fact, our previous study demonstrated that the overexpression of carnosine synthase increased 2-oxo-carnosine production in H 2 O 2 - or rotenone-treated SH-SY5Y cells, resulting in the cytoprotection from the oxidative stress-induced cell death [ 4 ]. Taken together, the conversion of IDPs to 2-oxo-IDPs may be critical for the protective effects of IDPs against the various oxidative stress-related diseases previously reported [ 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 81%

“…A previous study demonstrated that small amounts of hydrazine (0.01-0.20%), a strong reductant, were present in various sources of commercial carnosine, thereby interfering with lipid oxidation [38]. These results suggest that impurities in the standards could affect the antioxidant capacity of IDPs and the protective effects of IDPs against various oxidative stress-related diseases previously reported [39][40][41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 86%

“…Various studies have demonstrated the beneficial effects of dietary supplementation with carnosine or anserine on various animal models of human diseases, including a streptozotocin-induced diabetic retinopathy rat model [ 53 ]; a cirrhotic rat model by bile duct ligation [ 54 ]; an ethanol-induced chronic liver injury in mice [ 55 ]; a focal ischemia rat model [ 39 ]; and a transgenic mice model of Alzheimer’s disease [ 40 ]. Further, to date, multiple double-blind, placebo-controlled, randomized controlled clinical trials have been conducted with oral carnosine supplementation.…”

Section: Discussionmentioning

confidence: 99%

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2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides

et al. 2021

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There is substantial evidence for the antioxidant functions of imidazole-containing dipeptides (IDPs), including carnosine and anserine, under physiological and pathological conditions in vivo. However, the detailed mechanism underlying the antioxidant functions is still poorly understood. Recently, we discovered the endogenous production of 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs), such as 2-oxo-carnosine and 2-oxo-anserine, as novel derivatives of IDPs in mouse tissues and revealed that the antioxidant capacity of 2-oxo-carnosine was much greater than that of carnosine. However, the antioxidant capacity of 2-oxo-IDPs still remains unclear. In this study, we evaluated 2-oxo-carnosine and 2-oxo-anserine by multiple in vitro assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing/antioxidant power, and oxygen radical absorbance capacity assays in comparison with the corresponding IDPs, carnosine and anserine. All the assays employed herein demonstrated that 2-oxo-carnosine and 2-oxo-anserine exhibited a greater antioxidant capacity than that of the corresponding IDPs. Quantitative high-performance liquid chromatography tandem mass spectrometry revealed that commercial IDPs standards were contaminated with a certain amount of 2-oxo-IDPs, which was correlated with the antioxidant capacity. DPPH radical scavenging assay revealed that the elimination of contaminated 2-oxo-IDPs from the IDPs standards caused a significant decrease in the antioxidant capacity compared to the original IDPs standards. These results suggest that the main driver of the antioxidant capacity of IDPs is 2-oxo-IDPs; accordingly, the conversion of IDPs to 2-oxo-IDPs may be a critical step in the antioxidant functions.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides

et al. 2021

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“…These effects include decreased plasma glucose and amelioration of diabetic complications (e.g., nephropathy, ocular damage, and retinopathy) in diabetic mice (Lee et al 2005;Pfister et al 2011); reduced lipid oxidation and augmented anti-oxidative capacities [e.g., restoring of blood glutathione and basal activities of antioxidant enzymes in aging rats (Aydin et al 2010a,b;Hipkiss and Brownson 2000)] and in pigs (Ma et al 2010); amelioration of acetaminophen-induced liver injury (Yan et al 2009), thioacetamide-or hyperammonemia-induced liver cirrhosis (Aydin et al 2010a,b;Jamshidzadeh et al 2017b), and ethanol-induced chronic liver injury in rats (Liu et al 2008). Dietary supplementation with carnosine also results in decreases in malondialdehyde, oxidative stress (including ischemic oxidative stress and cerebral ischemia), and ethanol-induced protein carbonyls in brains (Berezhnoy et al 2019;Fedorova et al 2018); amelioration of neurological disorders, including autism spectrum disorder in children (Chez et al 2002;Kawahara et al 2018); protection against cardiovascular injury (Abplanalp et al 2019;Artioli et al 2019) and bleomycin-induced lung fibrosis in rats (Cuzzocrea et al 2007); cardiomyopathy in rats induced by chemotherapeutic agents that cause hydroxyl radical formation and lipid peroxidation (Dursun et al 2011); ROS-induced renal damage in mice (Fouad et al 2008); and promotion of wound healing in rodents (Ansurudeen et al 2012). Through augmenting respiratory burst in neutrophils and their production of ROS, as well as modulating the release of the virulent influenza virus from activated neutrophils, oral administration of carnosine and anserine reduces virus dissemination in humans (Babizhayev and Deyev 2012;Babizhayev et al 2014).…”

Section: Health Benefits Of Carnosine Supplementationmentioning

confidence: 99%

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

2020

Amino Acids

331

192

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Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino acid; also often referred to as an amino acid) were discovered in cattle, and the discovery of anserine (a methylated product of carnosine; β-alanyl-1-methyl-l-histidine) also originated with cattle. These five nutrients are highly abundant in beef, and have important physiological roles in anti-oxidative and antiinflammatory reactions, as well as neurological, muscular, retinal, immunological and cardiovascular function. Of particular note, taurine, carnosine, anserine, and creatine are absent from plants, and hydroxyproline is negligible in many plant-source foods. Consumption of 30 g dry beef can fully meet daily physiological needs of the healthy 70-kg adult human for taurine and carnosine, and can also provide large amounts of creatine, anserine and 4-hydroxyproline to improve human nutrition and health, including metabolic, retinal, immunological, muscular, cartilage, neurological, and cardiovascular health. The present review provides the public with the much-needed knowledge of nutritionally and physiologically significant amino acids, dipeptides and creatine in animal-source foods (including beef). Dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults. Furthermore, these nutrients may promote the immunological defense of humans against infections by bacteria, fungi, parasites, and viruses (including coronavirus) through enhancing the metabolism and functions of monocytes, macrophages, and other cells of the immune system. Red meat (including beef) is a functional food for optimizing human growth, development and health.

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“…L-carnosine has clinical evidence for its action against chemotherapy-induced toxicities [69,70], but no research has been conducted on its anticancer activity. Pre-clinical evidence from cardiovascular research suggests that L-carnosine improves functional capability in ischemia circumstances [71][72][73][74][75][76][77][78]. Similarly, pre-clinical evidence from diabetes studies showed that L-carnosine had an effect on diabetes [79,80] and its complications [81][82][83].…”

Section: Discussionmentioning

confidence: 99%

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

Sureshkumar¹,

Durairaj²,

Srinivasan³

et al. 2023

Front. Biosci. (Landmark Ed)

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Introduction: L-carnosine has been found to have multimodal activity. Aim: The aim of this review was to find out the efficacy of Lcarnosine in patients with age-related diseases. Methods: Clinical studies evaluated the effect of L-carnosine on cancer, cardiovascular disease, diabetes, and neurodegenerative disorders were searched in electronic bibliographic databases. The protocol has been registered with PROSPERO (CRD42022314033). The revised Cochrane risk of bias tool for randomized trials was used to assess all of the reports for risk of bias. RevMan 5.4 was used to conduct the meta-analysis. Results: Following the screening process, 14 papers were selected for systematic review, with 9 of them being qualified for meta-analysis. Many of the included studies showed that L-carnosine has potential therapeutic activity in age related diseases. Results from the meta-analysis showed that in diabetes mellitus, HbA1c [mean difference (MD) 95% CI = -1.25 (-2.49, -0.022); p = 0.05; p = 0.001; I 2 = 85%] and fasting blood sugar (FBS) [MD 95% CI = -12.44 (-22.44, -2.44); p = 0.01; p = 0.40; I 2 = 0%] and in neurodegenerative disorder, Wechsler Memory Scale Logical Memory 2 (WMS-LM2) [MD 95% CI = 1.34 (0.83, 1.85); p < 0.00001; p = 0.43; I 2 = 0%], showed statistically significant difference, favoring the L-carnosine group over the control group. While in neurodegenerative disorder, Alzheimer 's Disease Assessment Scale (ADAS) [MD 95% CI = 0.98 (-1.55, -0.42); p = 0.0007; p = 0.86; I 2 = 0%] and Back Depression Inventory (BDI) [MD 95% CI = -1.12 (-1.87, -0.37); p = 0.003; p = 0.73; I 2 = 0%] showed statistically significant difference, favoring the control group over L-carnosine group. Conclusions: Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.

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Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine

Cited by 6 publications

References 9 publications

2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides

2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides

Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health

Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis

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