Oxidative stability of sesame and flaxseed oils and their effects on morphometric and biochemical parameters in an animal model

Figueiredo, Priscila Gonzáles; Cândido, Camila Jordão; Jaques, Jeandre As; Nunes, Ângela Alves; Caires, Anderson R. L.; Michels, Flávio S.; Almeida, Jeeser Alves de; Filiú, Wander Fo; Hiane, Priscila Aiko; Nascimento, Valter Aragão do; Franco, Octávio L.; Guimarães, Rita Ca

doi:10.1002/jsfa.8186

Cited by 21 publications

(19 citation statements)

References 26 publications

(29 reference statements)

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“…The effect of linseed oil on plasma cholesterol level in clinical studies has been reported differently [27]. In experimental rabbit and chicken models of hypercholesterolaemia [7,28], linseed oil did not affect cholesterol concentration, whereas in rat models, it reduced total and non-HDL-C [3] or non-HDL-C and TGs [23]. In this study, we observed that linseed oil increased both HDL 3 -C and total HDL concentrations.…”

Section: Discussionmentioning

confidence: 49%

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Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

et al. 2018

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A b s t r a c tBackground: Linseed oil has cardio-protective effects. However, its antihypertensive action has not yet been well characterised. Aim:The primary purpose of the study was to evaluate the effect of short-term dietary supplementation with linseed oil on blood pressure (BP) and lipid metabolism in patients with mild hypercholesterolaemia. The secondary aim was to assess the effect of linseed oil on nitric oxide pathway and selected serum trace metals.Methods: 150 volunteers: 43 men (49.9 ± 11.5 years) and 107 women (53.2 ± 10.3 years), diagnosed with mild hypercholesterolaemia, were assessed prospectively for BP and lipid levels, before and after lipid-lowering diet plus linseed oil supplementation at a dose of 15 mL daily for four weeks (study groups) or four-weekly lipid-lowering diet (control group). Multivariate logistic regression analysis was used to determine the effect of linseed oil on BP after adjustment for age, sex, height, body weight, body mass index, smoking status, and alcohol consumption.Results: Supplementation with linseed oil significantly decreased low-density lipoprotein (LDL)-and non-high-density lipoprotein (HDL) cholesterol, and increased HDL-and HDL 3 -cholesterol levels. Additionally, linseed oil decreased diastolic BP in men (95% confidence interval [CI]: -6.0 to -1.1, p < 0.006), whereas in women linseed oil reduced (p < 0.001) systolic BP (-3.6 mmHg; 95% CI: -5.8 to -1.5) as well as diastolic BP (-4 mmHg; 95% CI: -5.8 to -2.1). Women with higher BP displayed an increase in serum L-arginine level (p < 0.01). In the logistic regression model oil consumption was associated with a decrease in mean BP (adjusted odds ratio 3.85; 95% CI 1.32-11.33). Conclusions:Our findings confirm the benefit of short-term linseed oil use in mild hypercholesterolaemia, particularly in patients with increased blood pressure.

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Section: Discussionmentioning

confidence: 49%

“…Omega-3 (n-3) fatty acids: docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α-linolenic acid (ALA), can modify the residual cardiovascular risk. All these acids improve lipid pattern [2,3] and insulin sensitivity [4], attenuate oxidative stress [5], and decrease prothrombotic [6] as well as proinflammatory [7] potentials.…”

Section: Introductionmentioning

confidence: 99%

Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

et al. 2018

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“…The FAs of the n-3 series are capable of minimizing the acute and chronic inflammation through various associated effects, whereas the eicosanoids derived from the excess of n-6 PUFAs formed in the organism are potent mediators of thrombosis and inflammation. Therefore, though not quite a consensus, most reports recommend an increase in ingestion of n-3 FA, aiming to lower the proportion of n-6 to n-3 and prevent several pathologies [14]. The mechanisms of the effects of n-3 can include a change in the composition of lipidic membranes, higher energetic expenditure, less formation of reactive oxygen species (ROS), and activation of peroxisome proliferator-activated receptor (PPAR), which act to decrease the activation of inflammatory pathways, such as c-Jun N terminal kinase (JNK) and nuclear factor-κB (NF-κB).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

et al. 2019

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Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases in metabolic disorders of obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil is a primary source of n-3 fatty acids (FAs) of plant origin, particularly α-linolenic acid, and provides an alternative for the ingestion of n-3 PUFA by persons allergic to, or wishing to avoid, animal sources. In our study, we evaluated the effect of the consumption of different lipidic sources on metabolic and inflammatory parameters in Wistar rats. We split 56 male rats into four groups that were fed for 60 days with the following diets: sesame oil, (SO, Sesamum indicum), linseed oil (LO), SO + LO (SLO), and a control group (CG) fed with animal fat. Our results reveal that the use of LO or SLO produced improvements in the hepatic tissue, such as lower values of aspartate aminotransferase, liver weight, and hepatic steatosis. LO and SLO reduced the weight of visceral fats, weight gain, and mediated the inflammation through a decrease in interleukin (IL)-6 and increase in IL-10. Though we did not detect any significant differences in the intestine histology and the purinergic system enzymes, the consumption of α-linolenic acid appears to contribute to the inflammatory and hepatic modulation of animals compared with a diet rich in saturated FAs and or unbalanced in n-6/n-3 PUFAs, inferring possible use in treatment of metabolic disorders associated with obesity and cardiovascular diseases.

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“…Taking that into account, we used the FDA criteria [30] for nutrient claims to determine if the pulp or the seed are sources for a specific element regarding its content.…”

Section: Comparison Criteriamentioning

confidence: 99%

Canjiqueira Fruit: Are We Losing the Best of It?

Arakaki

Santos

Melo

et al. 2020

Foods

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Fruits and byproducts are valuable sources of nutrients and bioactive compounds, which are associated with a decreased risk of developing several diseases, such as cancer, inflammation, cardiovascular diseases, and Alzheimer's. The fruits of canjiqueira (Byrsonima cydoniifolia) are already exploited as a food resource, while the seeds are discarded. This study aimed at showing the potential of the whole fruit of canjiqueira. Elemental characterization was performed on ICP OES, while thermal stability was assessed on thermogravimetry. The determination of the fatty acid profile was carried out on gas chromatography and bioactive compound identification using liquid chromatography and mass spectrometry. Results show that both parts of canjiqueira fruit are a source of various minerals, such as Ca, Cu, Fe, K, Mg, and Mn while the seed only is a good source for Zn. Oleic and linoleic acids are the main compounds in pulp and seed. The thermal stability of seed oil is superior to pulp oil, while piceatannol concentration is higher in seed than pulp. All parts of canjiqueira fruit may be used as a strategy to address nutrition issues and are valuable ingredients to prospective food products.

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Oxidative stability of sesame and flaxseed oils and their effects on morphometric and biochemical parameters in an animal model

Abstract: Sesame oil was more stable than flaxseed oil. In an animal model, the diets with polyunsaturated fat sources proportions of 1:1 n-6:n-3 polyunsaturated fatty acids, improved the metabolic parameters, implying cardioprotective effects. © 2016 Society of Chemical Industry.

Cited by 21 publications

References 26 publications

Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

Linseed oil increases HDL3 cholesterol and decreases blood pressure in patients diagnosed with mild hypercholesterolaemia

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

Canjiqueira Fruit: Are We Losing the Best of It?

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