Oxidative Reactions of Hydroxylated Chlorpromazine Metabolites

Chemical and electrochemical oxidation of 7-hydroxychlorpromazine

“…Preliminary electrochemical investigation in our laboratory indicated that the oxidation of 2 is a reversible two-electron process to form 3 but that the oxidation of 1 is much more complex. 18 Thus this report emphasizes the results of a more in-depth examination of the oxidation of 1.…”

“…of 1 at pH 2 were qualitatively identical with those at pH 4, reported elsewhere. 18 During the early portion of the electrolysis at pH 2 the solution was purple, before a gradual transition to the red color of 3. Chronoamperometry allows oxidation to be monitored on a 0.01-1-s time scale, much faster than the tens of minutes required for coulometry. By switching on the potential at a value of +0.75 V in an unstirred solution of 1, the electroactive species immediately next to the electrode may be electrolyzed and the number of electrons involved in the oxidation may be determined from the resulting current.…”

Pulse radiolysis and cyclic voltammetry studies of redox properties of phenothiazine radicals

“…The widespread use of phenothiazine (PZ) derivatives as sedatives and in the treatment of mental illness has inspired much research on their chemical properties and reactivity (McCreery, 1977;Usdin et al, 1980;Forrest et al, 1974). Fig.…”

How many FT-IR Spectrometers does it take to do GC-IR, TG-IR, and IR Microscopy.... … and then upgrade to FT-Raman next year

“…For example, as is evidenced by the work of Adams and co-workers on the electrochemistry of catechol amine neurotransmitters (32,33) and of McCreery and co-workers on the electrochemical oxidation of phenothiazine tranquilizer drugs (34,35), electrochemical methods are well suited to provide insight into redox and related chemical reactivity of compounds of biological interest. Ad ams' studies have provided insights into the ways in which catechol amines and the intermediates formed during electrooxidation might be involved in certain types of neuro chemical behavior.…”