Oxidative phosphorylation in liver mitochondria in the toxic form of experimental influenza

Bykova, N. O.; Gorbunov, Nikolai V.; Volgarev, A. A.; Savina, Margarita V.; Иванова, Т. И.; Egoyants, M. A.; Vanin, V. F.; Prozorovskaya, M. L.

doi:10.1007/bf00840518

Cited by 3 publications

(4 citation statements)

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“…This procedure was repeated nine times at nitric oxide concentrations from 100 to 2100 ppm. The NO uptake in the respiratory system at the respiration rate 12 breaths/min and inhaled volume 1 L/breath was calculated as (1) where and are expressed in ppm, and m, in mg/s [43].…”

Section: Synthesis Of Binuclear Dnics With Glutathione and N-acetyl-l-cysteine Both B-dnic-gsh And B-dnic-nac Were Synthesized In A Thunbmentioning

confidence: 99%

“…It has been shown that most disorders induced by viral infections in animal and human bodies lead to a dramatic increase in the levels of nitric oxide NO, reactive oxygen species, and various cytokines in host cells and tissues [1][2][3][4][5][6][7]. In most cases, this NO increase protects cells and tissues from the infection [2,[5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19

et al. 2021

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Section: Synthesis Of Binuclear Dnics With Glutathione and N-acetyl-l-cysteine Both B-dnic-gsh And B-dnic-nac Were Synthesized In A Thunbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19

et al. 2021

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“…Viral infections are characterized by a sharp increase in the level of nitric oxide (NO), one of the universal regulators of metabolic processes in host cells [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. The intracellular increase in the NO concentration is accompanied by S-nitrosation of various viral proteins, i.e., proteases, envelope proteins, reverse transcriptases, transcription factors, and host cell proteases [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Fig.3. EPR spectra of lungs(1), liver(2), and blood (3) of hamsters exposed to 30-min inhalation of a sprayed 10 mM DETC solution followed by 30-min inhalation of a sprayed 10 mM solution of B-DNIC-GSH (DETC + DNIC). The signal at g = 2.0 is caused by endogenous free radicals.…”

mentioning

confidence: 99%

Antiviral Activity of Nitrosonium Cations against SARS-CoV-2 on a Syrian Hamster Model

et al. 2022

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The antiviral action of binuclear dinitrosyl iron complexes with glutathione along with diethyldithiocarbamate against the SARS-CoV-2 virus has been demonstrated on a Syrian hamster model after aerosol exposure of SARS-CoV-2-infected animals to the solutions of said compounds. EPR assays in analogous experiments on intact hamsters have demonstrated that the iron complexes and diethyldithiocarbamate are predominantly localized in lung tissues. These results have been compared with similar measurements on intact mice, which have shown the equal localization of these agents in both the lungs and liver. We assume that the release of the nitrosonium cations from the binuclear dinitrosyl iron complexes with glutathione occurs during their contact with diethyldithiocarbamate in the animal body. These cations caused S-nitrosation of host and viral cell proteases, leading to suppression of SARS-CoV-2 infection.

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Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation

Peterhans

1997

The Journal of Nutrition

205

135

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Reactive oxygen and nitrogen metabolites play a complex role in many diseases and in metabolic regulation. Because viruses replicate in living cells, such metabolites influence the growth of viruses in addition to serving as a host defense mechanism. Low levels of reactive oxygen species (ROS) play a role in mitogenic activation, and the early phase of lytic and nonlytic virus infection indeed resembles that of mitogenic cell activation. In addition to these subtle cell-activating effects shared by many viruses, influenza and paramyxoviruses activate a respiratory burst in phagocytic cells. These viruses are toxic when injected in animals. Cells lavaged from the lungs of mice infected with influenza virus are primed for enhanced superoxide generation. Moreover, xanthine oxidase is enhanced and the buffering capacity of small molecular antioxidants is decreased in the lungs, suggesting that infection leads to oxidative stress. The wide array of cytokines produced in the lungs during influenza could contribute to the systemic effects of influenza. Oxidative stress has also been shown in human immunodeficiency virus (HIV) infection in humans. Via activation of NF kappa B, ROS may activate viral replication, but oxidants are believed to contribute also to the loss of CD4 T cells by apoptosis. Antioxidants, together with agents interfering with the harmful effects of cytokines and lipid mediators, may have a role in the treatment of viral diseases. Such agents could not only alleviate disease symptoms but also decrease the long-term effects of chronic oxidative stress, which have been linked to the development of cancer in some viral infections.

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Oxidative phosphorylation in liver mitochondria in the toxic form of experimental influenza

Cited by 3 publications

References 4 publications

Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19

Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19

Antiviral Activity of Nitrosonium Cations against SARS-CoV-2 on a Syrian Hamster Model

Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation

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