Oxidative modifications of foetal LDL-c and HDL-c lipoproteins in preeclampsia

León-Reyes, Guadalupe; Sosa, Salvador Espino Y; Medina-Navarro, Rafael; Guzmán-Grenfell, Alberto Martı́n; Moeini, Aida; Fuentes-García, Silvia; Ga, Hicks; Torres-Ramos, Yessica Dorín

doi:10.1186/s12944-018-0766-9

Cited by 10 publications

(5 citation statements)

References 37 publications

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“…We observed that total cholesterol, as well as non-HDL-C, were profoundly increased in neonates of early-onset PE, while triglyceride levels and HDL-C were unaltered. These results of lipid measurements in PE cord blood are in line with a previous study [ 81 ]. However, it has to be noted that in our study, these changes were only seen in early-onset PE, which represents the more severe type.…”

Section: Discussionsupporting

confidence: 93%

Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring

et al. 2023

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Preeclampsia (PE) is linked to an overall increased cardiovascular risk for both the mother and child. Functional impairment of high-density lipoproteins (HDL) may contribute to the excess cardiovascular risk associated with PE. In this study, we investigated the effects of PE on maternal and neonatal lipid metabolism, and the parameters of HDL composition and function. The study cohort included 32 normotensive pregnant women, 18 women diagnosed with early-onset PE, and 14 women with late-onset PE. In mothers, early- and late-onset PE was associated with atherogenic dyslipidemia, characterized by high plasma triglycerides and low HDL-cholesterol levels. We observed a shift from large HDL to smaller HDL subclasses in early-onset PE, which was associated with an increased plasma antioxidant capacity in mothers. PE was further associated with markedly increased levels of HDL-associated apolipoprotein (apo) C-II in mothers, and linked to the triglyceride content of HDL. In neonates of early-onset PE, total cholesterol levels were increased, whereas HDL cholesterol efflux capacity was markedly reduced in neonates from late-onset PE. In conclusion, early- and late-onset PE profoundly affect maternal lipid metabolism, potentially contributing to disease manifestation and increased cardiovascular risk later in life. PE is also associated with changes in neonatal HDL composition and function, demonstrating that complications of pregnancy affect neonatal lipoprotein metabolism.

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Section: Discussionsupporting

confidence: 93%

Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring

et al. 2023

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“…Of particular interest, the PE-associated oxidative modifications of lipids in HDL and LDL were also found in fetal lipoproteins, showing that also the infants are affected by increased oxidative stress and clear transplacental transmission of these effects in PE [ 182 ]. Similar to the results in PE mothers [ 177 ], PON1 activity was also shown to be decreased in the cord blood of the newborns [ 182 ]. In another study, HDL isolated from cord blood of PE pregnancies was reported to be linked with significantly reduced levels of apoM [ 138 ].…”

Section: Pregnancy-related Diseases Affects Hdl Metabolism and Functionmentioning

confidence: 99%

Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease

2021

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Cholesterol and other lipids carried by lipoproteins play an indispensable role in fetal development. Recent evidence suggests that maternally derived high-density lipoprotein (HDL) differs from fetal HDL with respect to its proteome, size, and function. Compared to the HDL of adults, fetal HDL is the major carrier of cholesterol and has a unique composition that implies other physiological functions. Fetal HDL is enriched in apolipoprotein E, which binds with high affinity to the low-density lipoprotein receptor. Thus, it appears that a primary function of fetal HDL is the transport of cholesterol to tissues as is accomplished by low-density lipoproteins in adults. The fetal HDL-associated bioactive sphingolipid sphingosine-1-phosphate shows strong vasoprotective effects at the fetoplacental vasculature. Moreover, lipoprotein-associated phospholipase A2 carried by fetal-HDL exerts anti-oxidative and athero-protective functions on the fetoplacental endothelium. Notably, the mass and activity of HDL-associated paraoxonase 1 are about 5-fold lower in the fetus, accompanied by an attenuation of anti-oxidative activity of fetal HDL. Cholesteryl ester transfer protein activity is reduced in fetal circulation despite similar amounts of the enzyme in maternal and fetal serum. This review summarizes the current knowledge on fetal HDL as a potential vasoprotective lipoprotein during fetal development. We also provide an overview of whether and how the protective functionalities of HDL are impaired in pregnancy-related syndromes such as pre-eclampsia or gestational diabetes mellitus.

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“…This highly supported our findings that increased levels of anti-angiogenic sFLT1 resulted in early maternal metabolic changes, also influencing fetal metabolism [ 15 ]. As reviewed in [ 38 ], neonates born from PE mothers showed increased levels of lipoproteins and also oxidative damage in lipoproteins [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1

Vogtmann

Bao

Dewan

et al. 2023

IJMS

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Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring’s metabolism, resulting in long-term metabolic changes. PE is characterized by increased circulating levels of sFLT1, placental dysfunction and fetal growth restriction (FGR). Here we examine the consequences of systemic human sFLT1 overexpression in transgenic PE/FGR mice on the offspring’s metabolic phenotype. Histological and molecular analyses of fetal and offspring livers as well as examinations of offspring serum hormones were performed. At 18.5 dpc, sFLT1 overexpression resulted in growth-restricted fetuses with a reduced liver weight, combined with reduced hepatic glycogen storage and histological signs of hemorrhages and hepatocyte apoptosis. This was further associated with altered gene expression of the molecules involved in fatty acid and glucose/glycogen metabolism. In most analyzed features males were more affected than females. The postnatal follow-up revealed an increased weight gain of male PE offspring, and increased serum levels of Insulin and Leptin. This was associated with changes in hepatic gene expression regulating fatty acid and glucose metabolism in male PE offspring. To conclude, our results indicate that sFLT1-related PE/FGR in mice leads to altered fetal liver development, which might result in an adverse metabolic pre-programming of the offspring, specifically targeting males. This could be linked to the known sex differences seen in PE pregnancies in human.

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Oxidative modifications of foetal LDL-c and HDL-c lipoproteins in preeclampsia

Cited by 10 publications

References 37 publications

Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring

Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring

Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease

Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1

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