Oxidative Imbalance and Non-Enzymic Antioxidant Status in Pulmonary Tuberculosis Infected Subjects: Carcinogenic Potential

The role of gene polymorphisms of glutamate-cysteine ligase catalytic (GCLC) enzyme against antioxidants and oxidative stress status of Individual who had contacted infectious tuberculosis

“…However, these levels are still higher compared to previous studies in patients with active TB before taking the anti-tuberculosis drug in which they shown an average level of glutathione (Nwanjo and Oze, 2007;Yuniastuti et al, 2013). This result indicates the different levels of glutathione between active TB and contacts of person with infectious TB due to the difference in the number of germs, levels of infection, and the imbalance between oxidants and antioxidants in the body.…”

“…However, not all oxidative stresses are caused by GCLC gene polymorphism that reduces the production of glutathione in the body. It may also be caused by several factors such as the presence of other infections, low intake of vitamins C and E, poor lifestyle such as heavy cigarette consumption, and also the presence of chronic diseases (Nwanjo and Oze, 2007;Siedlinski et al, 2008).…”

“…Glutathione is naturally present in the human body cells, has a dominant role in the regulation of the main cells in the intracellular redox reaction, and protect the body from oxidative stress by binding with free radicals (Koide et al, 2003). Various reports have reported that the levels of cellular antioxidant glutathione are significantly decreased in TB patients as well as other lung diseases (Nwanjo and Oze, 2007;Venketaraman et al, 2008;Akiibinu et al, 2011;Yuniastuti et al, 2013).…”

“…Moreover, phenotype indicates the severity of the disease, such as myocardial infarction, cancer, diabetes and HIV / AIDS (Koide et al, 2003;Wang et al, 2012). The GCL gene polymorphism and the level of glutathione and F2-isoprostanes in the TB patients and normal individuals have been describe (Nwanjo and Oze, 2007;Yuniastuti et al, 2013), but for the contacts of person with infectious TB have never been reported. That is why in this study we want to examine the association between the polymorphism in the GCLC gene with glutathione plasma level and F2-isoprostanes in contacts of person with infectious TB.…”

Oxidative Stress and Lipid Profile Status in Pulmonary Tuberculosis Patients in South Western Nigeria

“…Mycobacterium tuberculosis is considered as an etiologic agent of tuberculosis (TB) with the identifying feature of the organism been an acid -fast property (Nwanjo and Oze ,2007). Tuberculosis is a leading health problem worldwide and remains one of the leading causes of death from infectious disease.…”