volume 24, issue s2, P183-198 2011
DOI: 10.3233/jad-2011-110281
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Muralidhar L. Hegde, Pavana M. Hegde, K.S. Rao, Sankar Mitra

Abstract: The neurons in the central nervous system (CNS) with high O2 consumption and prolonged life span are chronically exposed to high levels of reactive oxygen species (ROS). Accumulation of ROS-induced genome damage in the form of oxidized bases and single-strand breaks (SSBs) as well as their defective or reduced repair in the brain has been implicated in the etiology of various neurological disorders including Alzheimer’s/Parkinson’s diseases (AD/PD). Although inactivating mutations in some DNA repair genes hav…

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