Oxidative Free-Radical C(sp2)–H Bond Chlorination of Enaminones with LiCl: Access to Highly Functionalized α-Chlorinated Enaminones
Yunhua Xie,
Zhilai Zhang,
Biao Zhang
et al.
Abstract:An oxidative free-radical C(sp2)–H
bond chlorination
strategy of enaminones has been developed by using LiCl as a chlorinating
reagent and K2S2O8 as an oxidant.
This transformation provides a new and straightforward synthetic methodology
to afford highly functionalized α-chlorinated enaminones with
a Z-configuration in good to excellent yields.
The direct synthesis of α-chloroenaminones has been described via one-pot atom-economical reactions. The reactions involving o-phenylenediamines delivered 1,4-benzodiazepines as products.
The direct synthesis of α-chloroenaminones has been described via one-pot atom-economical reactions. The reactions involving o-phenylenediamines delivered 1,4-benzodiazepines as products.
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