Oxidative Enzymes of the Liver in Protein Depletion

Wainio, W.W.; Eichel, Bertram; Eichel, Herbert J.; Person, Philip; Estes, Frances L.; Allison, J. B.

doi:10.1093/jn/49.3.465

Cited by 61 publications

(11 citation statements)

References 22 publications

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“…The results showed that the specific activity o f cytochrome c oxidase is not altered by protein deficiency. This is in agreement with the reports of others (7,11). However, reduction in cytochrome oxidase activity in experiments with adult rats (initial body weights of 300 g) fed a protein-free diet for 8 weeks has been reported (13).…”

Section: Discussionsupporting

confidence: 93%

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Rat Liver Mitochondrial Cytochrome c Oxidase and Cytochromes in Experimental Protein-Energy Malnutrition

Ramanadham¹,

Kaplay²

1978

Ann Nutr Metab

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Cytochrome c oxidase activity and cytochromes b, (c+c₁) and a(+a₃) concentrations were determined in liver mitochondria from rats fed the following diets: controls (group 1) fed ad libitum, energy-restricted (group 2) and protein-deficient (group 3). The animals were fed for two time intervals, 3--5 and 7–9 weeks. At 3–5 weeks, the cytochrome oxidase specific activity (nmol cytochrome c oxidized/mg protein/min) and cytochrome concentrations (nmol/mg protein) were not different in groups 2 and 3 as compared to group 1. At 7–9 weeks, the cytochrome oxidase specific activity and concentrations of cytochromes b, (c+c₁) and a(+a3) were significantly reduced in group 2 rats as compared to well-fed controls. The Michaelis-Menten constant, K_m apparent for ferrocytochrome c, was significantly higher in group 2 as compared to group 1. In group 3 rats, cytochrome oxidase specific activity and cytochrome b, a(+a₃) concentrations were not different from group 1 at 7–9 weeks. However, cytochrome (c+c₁) concentration was higher in group 3, resulting in an elevated ratio of cytochrome (c+c₁) to cytochrome a(+a₃) as compared to groups 1 and 2.

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Section: Discussionsupporting

confidence: 93%

“…According to some, protein deficiency leads to reduction in cytochrome concentrations and cyto chrome oxidase activity (13,14) while some others have found unaltered activ ity after protein depletion (7,11).…”

mentioning

confidence: 99%

Rat Liver Mitochondrial Cytochrome c Oxidase and Cytochromes in Experimental Protein-Energy Malnutrition

Ramanadham¹,

Kaplay²

1978

Ann Nutr Metab

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“…This enzyme loss has been demonstrated in proteindepleted animals and in malnourished children (19,20). The fact that death may occur in a depleted animal even when it is being re-fed and is apparently retaining nitrogen (2,3,6,18) indicates that protein loss alone is not the cause of death.…”

Section: Fig 3 Plasma Protein Activity In Dogs Given L-s'-methioninmentioning

confidence: 85%

The Effect of Protein Depletion on the Distribution of Protein Synthesis in the Dog

Garrow¹

1959

J. Clin. Invest.

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“…obs.] and may reflect a reduction in the 'labile pro tein' [25][26][27] of non-structural but energy consuming proteins such as oxidative en zymes in skin, intestine and liver. This early loss of protein is probably a consequence of adaptive hormonal responses which reduce the rate of protein synthesis.…”

Section: Discussionmentioning

confidence: 99%

Reduction in Resting Energy Expenditure in Relation to Lean Tissue Loss in Obese Subjects during Prolonged Dieting

Abraham¹,

Wynn²

1987

Ann Nutr Metab

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Resting energy expenditure (REE) was measured by indirect calorimetry during dieting (2.74–3.30 MJ/day) for up to 200 days in overweight patients undergoing continuous metabolic balance studies. The initial rapid reduction in REE in the first 2 weeks of dieting was related to the extent of the immediate nitrogen deficit that follows caloric restriction and was larger (p < 0.01) in men dieting de novo than either women (NS) or 4 patients of comparable lean body mass who had dieted prior to admission (NS). Because of their smaller metabolic energy deficit on our diets, the reduction in REE in women was small and not significant. In men, the slower long-term reduction in REE (p < 0.05) was related to a continuing loss of lean tissue with no changes in the REE/m², REE/kg body weight and REE/mmol creatinine excreted with time. We have previously shown that total energy expenditure (estimated from the rate of fat loss as measured by the difference between body weight changes and weight changes in fluid and protein) does not change significantly during prolonged dieting. The fall in REE in parallel with lean body mass suggests that some increase in the energy expended in daily activities must have occurred.

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Oxidative Enzymes of the Liver in Protein Depletion

Cited by 61 publications

References 22 publications

Rat Liver Mitochondrial Cytochrome c Oxidase and Cytochromes in Experimental Protein-Energy Malnutrition

Rat Liver Mitochondrial Cytochrome c Oxidase and Cytochromes in Experimental Protein-Energy Malnutrition

The Effect of Protein Depletion on the Distribution of Protein Synthesis in the Dog

Reduction in Resting Energy Expenditure in Relation to Lean Tissue Loss in Obese Subjects during Prolonged Dieting

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