Oxidative Effects of Lead in Young and Adult Fisher 344 Rats

Aykin-Burns, Nūkhet; Laegeler, A.; Kellogg, Gary; Erçal, Nuran

doi:10.1007/s00244-002-2023-4

Cited by 78 publications

(35 citation statements)

References 20 publications

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“…Depletion of tissue GSH is one of the primary factors that permit lipid peroxidation [27]. Results of the present work show significant decrease of GSH concentrations in the erythrocyte haemolysate of lead-exposed mice which is in line with previously published works [23,28,29]. Pb +2 binding to sulfhydryl groups can reduce GSH levels and can interfere with its antioxidant activity [18].…”

Section: Discussionsupporting

confidence: 90%

“…It is widely accepted that pollutant-induced reactive oxygen species (ROS) generation can initiate or promote lipid peroxidation. Lead-induced enhancement of thiobarbituric acid reactive substances (TBARS) have been reported in some tissues of animals [21][22][23][24][25] that can be due to the generation of ROS without commensurate increases in the level of antioxidant defenses [26]. Results of the present work showed a significant increase of MDA concentrations in the erythrocyte haemolysate of Pb-exposed mice.…”

Section: Discussionsupporting

confidence: 50%

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Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Lotfi-Ghahramanloo

Baghshani

2016

Zahedan J Res Med Sci

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 50%

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Lotfi-Ghahramanloo

Baghshani

2016

Zahedan J Res Med Sci

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“…Similarly, Aykin-Burns et al (2003) described that GSH levels in the brains of Pb-treated groups were found to be lower than in the control. 65) However, the concurrent treatment of Chlorella prevented GSH depletion, indicating the activity of a protective antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Chlorella vulgaris against Lead-Induced Oxidative Stress in Rat Brains

Yun

Kim

Kwon

et al. 2011

JOURNAL OF HEALTH SCIENCE

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Lead (Pb) is a toxic heavy metal widely distributed in the environment. Recent studies suggest oxidative stress as one possible mechanism involved in Pb poisoning. The unicellular algae Chlorella vulgaris (CV) contains various bioactive substances with antioxidant for the prevention of oxidative stress by metals. We investigated the protective effects of CV on the oxidative system in five groups of male Sprague-Dawley rats fed American Institute of Nutrition (AIN)-76 diet, plus 2, 5 or 10% CV for 4 weeks. All animals were exposed to 200 mg/l lead acetate by drinking water except for the control (tap water). Body weight gains were significantly reduced in the Pb-exposed group (64%) relative to the control and CV groups. Brain weights were significantly increased in the Pb-exposed group (44%) relative to the others. In the experimental period, food intake, water intake and Pb intake were not different among the groups. The levels of Pb (87%) in brain obtained from the Pb-exposed group were significantly increased compared to the other groups. The levels of oxidative stress parameters in the brain such as superoxide dismutase (36%), glutathione peroxidase (63%), and glutathione reductase (30%) were decreased in the Pb-exposed group relative to the control but markedly increased in the CV groups. The CV also significantly increased glutathione levels by approximately 1.7-fold over the Pb-exposed group, while the malondialdehye concentration significantly decreased by approximately 47-71%. Based on these results, we found alterations in several indicators of oxidative stress of Pb intoxication, suggesting the antioxidant potential of CV. Therefore, CV may have protective effects on brain damage of low-level and short-term Pb exposure in the brains of rats.

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“…Carotenoids are known to be involved in two important physiological functions: modulation of the immune system and detoxification . For example, heavy metals are known to produce oxidative stress in humans and animals, probably by disturbing the antioxidant-based defense of the body (Stohs and Bagchi, 1995;Mateo and Hoffman, 2001;Aykin-Burns et al, 2003). Food-derived antioxidants are consumed when the defense system is activated, and high amounts of pollutants in the body may lead to a depletion of antioxidants (Polidori et al, 2001;Krinsky and Yeum, 2003;Stehbens, 2003).…”

Section: Introductionmentioning

confidence: 99%

Environmental Pollution Affects the Plumage Color of Great Tit Nestlings through Carotenoid Availability

et al. 2008

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Birds need to acquire carotenoids for their feather pigmentation from their diet, which means that their plumage color may change as a consequence of human impact on their environment. For example, the carotenoid-based plumage coloration of Great tit, Parus major, nestlings is associated with the degree of environmental pollution. Breast feathers of birds in territories exposed to heavy metals are less yellow than those in unpolluted environments. Here we tested two hypotheses that could explain the observed pattern: (I) deficiency of carotenoids in diet, and (II) pollution-related changes in transfer of carotenoids to feathers. We manipulated dietary carotenoid levels of nestlings and measured the responses in plumage color and tissue concentrations. Our carotenoid supplementation produced the same response in tissue carotenoid concentrations and plumage color in polluted and unpolluted environments. Variation in heavy metal levels did not explain the variation in tissue (yolk, plasma, and feathers) carotenoid concentrations and was not related to plumage coloration. Instead, the variation in plumage yellowness was associated with the availability of carotenoid-rich caterpillars in territories. Our results support the hypothesis that the primary reason for pollution-related variation in plumage color is carotenoid deficiency in the diet.

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Oxidative Effects of Lead in Young and Adult Fisher 344 Rats

Cited by 78 publications

References 20 publications

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

Protective Effect of Chlorella vulgaris against Lead-Induced Oxidative Stress in Rat Brains

Environmental Pollution Affects the Plumage Color of Great Tit Nestlings through Carotenoid Availability

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