Oxidative DNA damage induced by autoxidation of microquantities of S(iv) in the presence of Ni(ii)–Gly-Gly-His

Alipázaga, María V.; Moreno, Ruben Gregorio Moreno; Linares, Edlaine; Medeiros, Marisa H. G.; Coichev, Nina

doi:10.1039/b507216f

Cited by 23 publications

(39 citation statements)

References 45 publications

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“…Is necessary to mention also that DNA and RNA damage can be correlated with nickel and cobalt ion catalyzed S(IV) autoxidation. [48][49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Autoxidation of Ni(II) and Co(II) tetra, penta and hexaglycine complexes accelerated by oxy sulfur radicals

Carvalho

Alipázaga

Lowinsohn

et al. 2006

J. Braz. Chem. Soc.

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A autoxidação dos complexos de Ni(II) e Co(II) com tetra, penta e hexaglicina, em meio de tampão borato, é acelerada por espécies de enxofre(IV) (H 2 SO 3 , HSO 3 -and SO 3 2-). A formação dos complexos de Ni(III) e Co(III) foi acompanhada espectrofotometricamente em 325 e 265 nm, respectivamente. Técnicas eletroquímicas também foram empregadas para caracterizar a geração destes complexos. A velocidade da reação de autoxidação aumenta com a concentração de S(IV) e é máxima em pH ≅ 8,5. O processo é autocatalítico com Ni(III) ou Co(III) atuando como iniciadores, formados pela oxidação espontânea de Ni(II) ou Co(II) pelo oxigênio molecular. A dependência da constante de velocidade de pseudo-primeira ordem com a concentração de sulfito evidenciou possíveis reações paralelas com formação de um complexo com ligantes mistos antes da etapa da oxidação.The autoxidation of Ni(II) and Co(II) complexes with tetra, penta and hexaglycine, in borate medium, is accelerated by sulfur(IV) species (H 2 SO 3 , HSO 3 -and SO 3 2-). The formation of Ni(III) and Co(III) complexes was followed spectrophotometrically at 325 and 265 nm, respectively. Electrochemical techniques were also employed to characterize the generation of these complexes. The autoxidation rate increases with S(IV) concentration and is maximum at pH ≅ 8.5. The process is autocatalytic with Ni(III) or Co(III) acting as initiators, formed by spontaneous oxidation by oxygen. The dependence of the pseudo first order rate constant with sulfite concentration showed evidences of back or parallel reactions with formation of mixed ligand complex prior to the oxidation step.

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“…Is necessary to mention also that DNA and RNA damage can be correlated with nickel and cobalt ion catalyzed S(IV) autoxidation. [48][49][50][51] .…”

Section: Discussionmentioning

confidence: 99%

Autoxidation of Ni(II) and Co(II) tetra, penta and hexaglycine complexes accelerated by oxy sulfur radicals

Carvalho

Alipázaga

Lowinsohn

et al. 2006

J. Braz. Chem. Soc.

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“…Os estudos aqui apresentados também indicaram que existem condições críticas (pH, concentração dos reagentes, natureza do íon metálico, ligante e concentração de oxigênio) a serem consideradas na etapa inicial da reação e na intensidade da lesão no DNA 95 . A identificação das espécies envolvidas nem sempre pode ser realizada com segurança, no entanto, estudos cinéticos combinados com equilíbrios de formação de íons complexos podem contribuir para um melhor entendimento da lesão oxidativa no DNA.…”

Section: Reação De Pirimidinas Com Ho •unclassified

Lesões em DNA induzidas pela autoxidação de S(IV) na presença de íons metálicos de transição

Moreno¹,

Alipázaga²,

Medeiros³

et al. 2006

Quím. Nova

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Recebido em 22/6/05; aceito em 18/11/05; publicado na web em 14/6/06 DNA DAMAGE INDUCED BY THE AUTOXIDATION OF S(IV) IN THE PRESENCE OF TRANSITION METAL IONS. The oxidation of sulfite catalyzed by transition metal ions produces reactive oxysulfur species that can damage plasmid and isolated DNA in vitro. Among the four DNA bases, guanine is the most sensitive to one-electron oxidation promoted by the species formed in the autoxidation of sulfite (HSO 5 -, HO • , SO 3 •-, SO 4 •-and SO 5•-) due to its low reduction potential and ability to bind transition metal ions capable to catalyze oxidative processes. Some oxidative DNA lesions are promutagenic and oxidative DNA damage is proposed to play a crucial role in certain human pathologies, including cancer.

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“…• formed in the process is strongly oxidising (reduction potential E o = 2.4) (Bao and Baker, 1996;Alipázaga et al, 2005) it is less reactive than hydroxyl radical (E o = 2.7) (Patnaik, 2004, Sawyer et al, 1995.…”

Section: Effect Of Anion Additivesmentioning

confidence: 99%

Photocatalytic Degradation of 2,4-dichlorophenol in Irradiated Aqueous ZnO Suspension

Gaya¹,

Abdullah²,

Zainal³

et al. 2010

IJC

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This paper focuses on the destruction of aqueous 2,4-dichorophenol in ZnO suspension irradiated by low wattage UV light at 299 K. The operating variables studied include initial 2,4-dichlorophenol concentration, photocatalyst doses and pH. At 1.5 g l -1 feed concentration of ZnO and 50 mg l -1 initial 2,4-dichlorophenol level, a complete degradation was achieved in 180 min. The decomposition kinetics with respect to 2,4-dichlorophenol approximates pseudo zero-order with rate constant peaking at 0.38 mg l -1 min -1 . High performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) detected benzoquinone, 2-chlorohydroquinone, 4-chlorophenol, 3,5-dichlorocatechol, hydroquinone, 4-hydroxybenzaldehyde and phenol during the ZnO-assisted photodegradation of 2,4-dichlorophenol among which some pathway products are disclosed for the first time. The reaction mechanism accounting for the degradation pathway intermediates is proposed. Inorganic anion additives such as S 2 O 8 2-, SO 4 2-, Cl -and HPO 4 2-manifested inhibition against 2,4-dichlorophenol removal.

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Oxidative DNA damage induced by autoxidation of microquantities of S(iv) in the presence of Ni(ii)–Gly-Gly-His

Cited by 23 publications

References 45 publications

Autoxidation of Ni(II) and Co(II) tetra, penta and hexaglycine complexes accelerated by oxy sulfur radicals

Autoxidation of Ni(II) and Co(II) tetra, penta and hexaglycine complexes accelerated by oxy sulfur radicals

Lesões em DNA induzidas pela autoxidação de S(IV) na presença de íons metálicos de transição

Photocatalytic Degradation of 2,4-dichlorophenol in Irradiated Aqueous ZnO Suspension

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