Oxidative DNA damage contributes to usnic acid‐induced toxicity in human induced pluripotent stem cell‐derived hepatocytes
Xiugong Gao,
Kayla Campasino,
Miranda R. Yourick
et al.
Abstract:Dietary supplements containing usnic acid have been increasingly marketed for weight loss over the past decades, even though incidences of severe hepatotoxicity and acute liver failure due to their overuse have been reported. To date, the toxic mechanism of usnic acid‐induced liver injury at the molecular level still remains to be fully elucidated. Here, we conducted a transcriptomic study on usnic acid using a novel in vitro hepatotoxicity model employing human induced pluripotent stem cell (iPSC)‐derived hep… Show more
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