Oxidative DNA Damage and Repair: Mechanisms, Mutations, and Relation to Diseases

Roginskaya, Marina; Razskazovskiy, Yuriy

doi:10.3390/antiox12081623

Cited by 5 publications

(7 citation statements)

References 16 publications

(23 reference statements)

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“…This peptide led to an increase in GSH-Px content, a decrease in MDA content, and the inhibition of ROS production (2) This peptide induced an increase in IKK and a corresponding inhibition of IκB degradation and nuclear p65 protein expression, leading to an inhibition of the NF-κB pathway.…”

Section: Crushed Rice Sgdwsdiggrmentioning

confidence: 87%

“…Oxidative stress in paraquat-treated C. elegans (1) These peptides reduced the content of ROS (2) They promoted the nuclear translocation of DAF-16 and induced the expression of target gene SOD-3.…”

Section: Aavpsgastgiyealelr Nplleafgnakmentioning

confidence: 98%

“…The peptide inhibited the production of ROS, MDA, and GSSG, prevented the decrease in GSH, and upregulated the activity of antioxidant enzymes (2) It upregulated the mRNA and protein expression levels of antioxidant enzymes (CAT, SOD, and GSH-Px), increased the expression of Nrf2 protein, and decreased the levels of Keap1 protein, thereby stimulating the Keap1-Nrf2-ARE pathway.…”

Section: Other Signaling Pathwaysmentioning

confidence: 98%

“…(1) This peptide reduced the release of LDH and inhibited the accumulation of reactive oxygen species (2) It stabilized the inhibitor I κ B protein and decreased the protein expression of p53 and Bax, thus inhibiting the NF-κ B pathway.…”

Section: Crushed Rice Sgdwsdiggrmentioning

confidence: 99%

“…The peptides decreased the levels of ROS and MDA and increased the activity of SOD (2) They upregulated the expression of SOD-3 or CAT-1 [69] Acaudina leucoprocta Protein hydrolysate Oxidative stress in paraquat-treated C. elegans…”

Section: Sepia Esculenta Dvedleaglak Eitslapstmmentioning

confidence: 99%

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Advances in Research on the Activity Evaluation, Mechanism and Structure-Activity Relationships of Natural Antioxidant Peptides

Xu,

Dong,

et al. 2024

Antioxidants

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Antioxidant peptides are a class of biologically active peptides with low molecular weights and stable antioxidant properties that are isolated from proteins. In this review, the progress in research on the activity evaluation, action mechanism, and structure-activity relationships of natural antioxidant peptides are summarized. The methods used to evaluate antioxidant activity are mainly classified into three categories: in vitro chemical, in vitro cellular, and in vivo animal methods. Also, the biological effects produced by these three methods are listed: the scavenging of free radicals, chelation of metal ions, inhibition of lipid peroxidation, inhibition of oxidative enzyme activities, and activation of antioxidant enzymes and non-enzymatic systems. The antioxidant effects of natural peptides primarily consist of the regulation of redox signaling pathways, which includes activation of the Nrf2 pathway and the inhibition of the NF-κB pathway. The structure-activity relationships of the antioxidant peptides are investigated, including the effects of peptide molecular weight, amino acid composition and sequence, and secondary structure on antioxidant activity. In addition, four computer-assisted methods (molecular docking, molecular dynamics simulation, quantum chemical calculations, and the determination of quantitative structure-activity relationships) for analyzing the structure-activity effects of natural peptides are summarized. Thus, this review lays a theoretical foundation for the development of new antioxidants, nutraceuticals, and cosmetics.

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Section: Crushed Rice Sgdwsdiggrmentioning

confidence: 87%

Section: Aavpsgastgiyealelr Nplleafgnakmentioning

confidence: 98%

Section: Other Signaling Pathwaysmentioning

confidence: 98%

Section: Crushed Rice Sgdwsdiggrmentioning

confidence: 99%

Section: Sepia Esculenta Dvedleaglak Eitslapstmmentioning

confidence: 99%

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