Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition

Thermal Stability of Simvastatin under Different Atmospheres

“…Organic pharmaceuticals often degrade through oxidation reactions 22 and the picture emerging from reports on the thermal behavior of solid SV indicate that the compound may undergo an exothermic oxidative degradation in air, which is very slow at ambient temperature and has an onset at approximately 401 K when the sample is heated in a differential scanning calorimeter at a rate of 2 K/min. 20 Under inert atmosphere (e.g., N 2 ), no thermal events are observed between 298 K and the fusion temperature (412 K), except for a glass transition at approximately 306 K if an amorphous phase is present.…”

Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

“…One of the most common modifications is oxidation of labile amino acid side chains, which is induced by reactive oxygen species. 1 Although protein oxidation can occur at cysteine, tryptophan, lysine and other amino acids, [2][3][4] methionine is often the most susceptible residue to oxidation. 5,6 The most common product of methionine oxidation is methionine sulfoxide, which is more polar and less hydrophobic than methionine.…”

Impact of Long-Term Storage on Stability of Standard DNA for Nucleic Acid-Based Methods

“…Degradation of nucleic acids features in the storage of specimens, for example, cerebrospinal fluid and whole blood, and other samples, including various pathogens, and in forensic applications (1,3,6,9,10,13,16,18,21). In a pharmaceutical context, the stability of plasmids during storage has been investigated (7,11,15). All these studies have investigated storage by freezing based on rapid freeze and thaw cycles included in the experiments, but long-term storage has been neglected.…”