Oxidative damage to protein and alterations to antioxidant levels in human cutaneous thermal injury

Haycock, John W.; Ralston, David R.; Morris, B W; Freedlander, E.; MacNeil, Sheila

doi:10.1016/s0305-4179(97)00072-7

Cited by 38 publications

(18 citation statements)

References 35 publications

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“…Mechanisms by which oxidative stress may contribute to progressive tissue destruction in the zone of stasis include lipid peroxidation of cell membranes and disruption of proteins and nucleic acids, culminating in cell death. 35,94,96 In general, ROS may mediate apoptosis through the cleavage of PARP, increases in mitochondrial permeability with the release of cytochrome C, and activation of caspases (see General Overview of Cell Death section). 97 ROS-triggered release of lysosomal contents can also lead to apoptosis.…”

Section: Burn Wounds and Free Radicalsmentioning

confidence: 99%

A Review of the Local Pathophysiologic Bases of Burn Wound Progression

Shupp

Nasabzadeh

Rosenthal

et al. 2010

Journal of Burn Care & Research

194

151

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Burn wound progression refers to the phenomenon of continued tissue necrosis in the zone of stasis after abatement of the initial thermal insult. A multitude of chemical and mechanical factors contribute to the local pathophysiologic process of burn wound progression. Prolonged inflammation results in an accumulation of cytotoxic cytokines and free radicals, along with neutrophil plugging of dermal venules. Increased vascular permeability and augmentations of interstitial hydrostatic pressure lead to edema with vascular congestion. Hypercoagulability with thrombosis further impairs blood flow, while oxidative stress damages endothelial cells and compromises vascular patency. A number of studies have investigated the utility of various agents in modulating these mechanisms of burn wound progression. However, as many of studies have used animal models of burn injury, often with administration of therapy preburn, obscuring the clinical applicability of the results to burn patients is of questionable benefit. An understanding of the complex, interrelated mediators of burn wound progression and their ultimate point of convergence in effecting tissue necrosis—cell apoptosis or oncosis—will allow for the future development of therapeutic interventions.

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Section: Burn Wounds and Free Radicalsmentioning

confidence: 99%

A Review of the Local Pathophysiologic Bases of Burn Wound Progression

Shupp

Nasabzadeh

Rosenthal

et al. 2010

Journal of Burn Care & Research

194

151

View full text Add to dashboard Cite

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“…These studies, which have produced conflicting results, have stimulated intense debate regarding blister management. Although most authors agree that blister fluid has similarities to serum with the addition of unique inflammatory factors associated with burn injury, some conclude there are specific benefits to be derived from blister fluid contact with the burn wound bed [22][23][24][25][26][27][28][29] whereas results from other studies show retarded wound healing and increased infection potential from chemical mediators found within the burn blister. 30 -35 This controversy, coupled with emerging research interest in growth factors 36 and gene therapies 37 in burn injury, drives current burn research and may eventually suggest new principles to be applied to the management of burn blisters.…”

Section: Historical Perspectivementioning

confidence: 99%

“…These findings support the evacuation of blister fluid to preserve mircrovascular circulation and to prevent the progression of partial-thickness to fullthickness burn. 26,27,30,47 Prevention of wound conversion in turn reduces the risk of infection as partialthickness wounds retain intact vascular supply and tissue viability and therefore are less susceptible to succumb to microbial invasion.…”

Section: Infectionmentioning

confidence: 99%

Management of Blisters in the Partial-Thickness Burn: An Integrative Research Review

Sargent

2006

Journal of Burn Care & Research

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Conflicting recommendations and clinical applications have been given concerning best practices for the management of burn blisters associated with partial-thickness burns. Arguments for the preservation of intact blisters center on the idea of naturally occurring biologic protection whereas the débridment of blisters has been advocated because of the perceived decreases in wound infection and complications. Recurring themes in burn wound management that are considered in this debate include infection, healing, functional and aesthetic outcome, patient comfort, ease of dressing care, and cost efficiency. The management of burn blisters should be supported by evidence across these six categories, should match the expertise of the provider, and should use the available resources in the practice setting. The purpose of this review is combine the findings of a comprehensive review of the published literature with respect to the management of blisters in the partial-thickness burn into a clinical guideline for best practice based on available evidence.

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“…[30] Kanbak et al reported that betaine has cytoprotective effect, decreasing MDA level and countering cytotoxic effect of free radicals caused by chronic ethanol administration to pancreas tissues. [31] In the current study, MDA level in lung tissue increased.…”

Section: Discussionmentioning

confidence: 99%