Oxidative damage: The biochemical mechanism of cellular injury and necrosis in choline deficiency

Repetto, Marisa G.; Ossani, Georgina Paula; Monserrat, Alberto J.; Boveris, Alberto

doi:10.1016/j.yexmp.2009.11.002

Cited by 48 publications

(53 citation statements)

References 29 publications

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“…Previous results indicate that lipid peroxidation has a role in the pathogenesis of several pathologies as neurodegenerative (Dominguez et al, 2008;Famulari et al, 1996;Fiszman et al, 2003), inflammatory (Farooqui & Farooqui, 2011), infectious , gastric and nutritional diseases (Repetto et al, 2010b).…”

Section: Biological Implications Of Lipid Peroxidationmentioning

confidence: 99%

“…In the liver, the morphological damage is previous to the lipid peroxidation and the consumption of endogenous antioxidants. In kidney and heart, indeed, lipid peroxidation and oxidative damage preceded necrosis (Repetto et al, 2010b).…”

Section: Biological Implications Of Lipid Peroxidationmentioning

confidence: 99%

“…The mechanism of lipid peroxidation in biological systems caused by free radicals has been the focus of scientific interest for many years (Chance et al, 1976;Fridovich  Porter, 1981;Fraga et al, 1988;Gonzalez-Flecha et al, 1991a, 1991bFamulari et al, 1996;Fiszman et al, 2003;Junqueira et al, 2004;Catala, 2006;Dianzani  Barrera, 2008;Dominguez et al, 2008;Repetto, 2008;Repetto et al, 2010b). Currently, it is known that the OH .…”

Section: Role Of Transition Metal On Lipid Peroxidation Processmentioning

confidence: 99%

“…Currently, it is known that the OH . radical, is formed mainly by the Haber-Weiss reaction, and it is responsible for the biological damage (Repetto et al, 2010a;Repetto et al, 2010b) (Eq.24):…”

Section: Role Of Transition Metal On Lipid Peroxidation Processmentioning

confidence: 99%

See 3 more Smart Citations

Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination

Repetto¹,

Semprine²,

Boveris³

2012

Lipid Peroxidation

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235

211

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Section: Biological Implications Of Lipid Peroxidationmentioning

confidence: 99%

Section: Biological Implications Of Lipid Peroxidationmentioning

confidence: 99%

Section: Role Of Transition Metal On Lipid Peroxidation Processmentioning

confidence: 99%

Section: Role Of Transition Metal On Lipid Peroxidation Processmentioning

confidence: 99%

See 2 more Smart Citations

Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination

Repetto¹,

Semprine²,

Boveris³

2012

Lipid Peroxidation

Self Cite

235

211

View full text Add to dashboard Cite

“…The cell membrane, which is composed of poly-unsaturated fatty acids, is a primary target of an ROS attack leading to cell membrane damage. Animals and plants have developed various protective mechanisms to eliminate or reduce ROS, such as an antioxidant system composed of both enzymatic (superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), and non-enzymatic (glutathione, ascorbic acid, tocopherol, and carotenoids) antioxidants (Halliwel B., Gutteridge 1999; Repetto et al, 2010). The equilibrium between the production and the scavenging of ROS may be disturbed by the stress factor.…”

Section: Introductionmentioning

confidence: 99%

Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

Poghosyan¹,

Mikaelyan²,

Nerkararyan³

et al. 2017

biologija

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Background. Electromagnetic irradiation with extremely high frequencies (EHF EMI) and low intensity affects living organisms of a different level of organization, but the mechanism(s) of its influence is still not understood well. This study was undertaken to examine the effects of EHF EMI on tissue lipid peroxidation (LPO) of whole body exposure rats.Material and methods. Male Wistar rats were selected for this study. The animals were divided into two groups: sham exposed and experimental. The rats were exposed to the EMI of 42.2 and 50.3 GHz frequencies (power density 0.06 mW/cm 2 ) for 20 min/ day, for five days. The content of malondialdehyde (MDA) as the final product of the LPO was estimated in brain, liver, heart, and skeletal muscle of rats.Results. Treatment with EMI induced oxidative stress in different organs of the rats, which was indicated by the changes of MDA level depending on the EMI frequency used and exposure duration. The MDA rate shows significant increase in brain (P < 0.001) depending on the treatment duration for both EMI frequencies used. The slightly elevated levels of MDA in the liver were observed among rats in 50.3 GHz frequency EMI-exposed group. Concerning the skeletal muscle and especially the cardiac tissue, the MDA values remained at the same levels in experimental and control groups and did not differ significantly.Conclusions. The EHF EMI applied in the multiple mode significantly enhanced the lipid peroxidation level in the brain and slightly increased the same parameter in liver. The obtained data indicate possible health implications of such exposures, which may cause damage in brain.

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Molecular pathology of acute kidney injury in a choline-deficient model and fish oil protective effect

et al. 2013

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This work was part of a large set of experiments and was used in a hypothesis-generating manner. The comprehensive analysis of genetic expression allowed confirming that menhaden oil has a protective effect on this nutritional experimental model and identifying 32 genes that could be responsible for that protection, including Gstp1. These results reveal that gene changes could play a role in renal injury.

show abstract

Oxidative damage: The biochemical mechanism of cellular injury and necrosis in choline deficiency

Cited by 48 publications

References 29 publications

Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination

Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination

Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

Molecular pathology of acute kidney injury in a choline-deficient model and fish oil protective effect

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