Oxidative damage of human skin lipids

Lasch, Jürgen; Schönfelder, Ute; Walke, Mathias; Zellmer, Sebastian; Beckert, D.

doi:10.1016/s0005-2760(97)00093-3

Cited by 29 publications

(12 citation statements)

References 23 publications

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“…39 The sebaceous gland releases sebum through the follicular duct to the uppermost skin layer, where several factors can induce the lipid oxidation including Propionibacterium acnes, UV exposure, or natural ROS. [40][41][42][43][44] The present findings and the previous studies suggest that skin lipids become more sensitive to the oxidation process than the body adipose tissue as hamsters grow older.…”

Section: Chemometrics Analysissupporting

confidence: 79%

Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy

Meksiarun

Maeda

Hiroi

et al. 2015

Analyst

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Raman spectroscopy has previously been applied for studying lipid metabolism. In this study, a ball lens-installed hollow optical fiber Raman probe (BHRP) was used for the noninvasive measurement of skin lipids in hamsters. Our analysis suggested that multi-unsaturated lipids, once converted into a structure containing conjugated double bonds, were oxidized to form peroxides. These results were applied for analyzing lipid metabolism in adipose and skin tissues in hamsters fed tricaprin, saturated medium-chain triglyceride and trilinolein, unsaturated long-chain triglyceride fat diets. Unsaturated lipids formed conjugated structures in skin tissue but not in adipose tissue. Principal component analysis (PCA) revealed that the dietary fat intake correlated strongly with lipid composition in body and skin tissues. Hence, the present results successfully demonstrate that Raman spectroscopy with a BHRP can be a powerful tool for analyzing lipid metabolism.

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Section: Chemometrics Analysissupporting

confidence: 79%

Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy

Meksiarun

Maeda

Hiroi

et al. 2015

Analyst

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“…644 A study of the oxidative damage to human skin lipids shows that peroxidation of fatty acids depended on the concentration of cholesterol. 645 The rate of lipid peroxidation of n-3 polyunsaturated fatty acids was found not to be suppressed by vitamin E ( -tocopherol) supplementation in the diet. 646 The loss of fluorescence of cis-parinaric acid [18:4(9Z,11Z,13Z,15Z)] is a sensitive indicator of lipid peroxidation, which has been applied to the study of peroxidation of unsaturated fatty acids in immune cells.…”

Section: Lipid Peroxidation and Autoxidationmentioning

confidence: 95%

Fatty acids, fatty acid analogues and their derivatives

Jie¹,

Pasha²

1998

Nat. Prod. Rep.

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“…The origins of radical initiators are oxidative environmental exposures and possibly also naturally occurring cutaneous bacteria which are a newly suggested source of oxidative entities (see below). Lipid peroxidation is a physiological process occurring naturally in the skin, but is nonetheless a chain reaction which can be deleterious to the cells and is often difficult to control, while its end products may interfere with normal cellular functions, affecting the delicate cutaneous PR homeostasis [ 59 ]. It is well established that α,β-unsaturated aldehydes (which are also ALEs) are able to activate the Nrf2–Keap1 pathway by direct Keap1 oxidation [ 52 , 60 ].…”

Section: Skin- and Bacteria-derived Metabolites Affect Pr Homeostamentioning

confidence: 99%

The Cutaneous Physiological Redox: Essential to Maintain but Difficult to Define

Ron-Doitch

Kohen

2020

Antioxidants

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Skin is a unique tissue, possessing extremely efficient protective and regulative mechanisms, similar only to the gut and lungs. These tissues serve as an interface with the environment and are exposed to stressors from both endogenous and exogenous sources. Interestingly, all these stressors lead downstream to a cellular production of reactive oxygen species (ROS) and other electrophiles, which, in turn could have deleterious outcomes for the living organism. Hence, such tissues should always maintain a “high-alert” condition in order to cope with these various insults. Nevertheless, a moderate production of ROS induced by stressors could actually be beneficial, although it is impossible to predict if and which exposure would lead to which outcome. Consequently, a parameter which would indicate the skin’s readiness to cope with continuously fluctuating conditions is required. It has been proposed that the redox status may serve as a suitable indicator. In this opinion manuscript, we argue that the redox status is a vague parameter that is difficult to characterized and quantify due to its extremely dynamic nature. The common convention that the redox status is composed solely of the balance between oxidants and reductants (ROS and antioxidants) is also thought-provoking. Since this parameter in vivo behaves in a dynamic and complex manner, it better fits the description of a process, rather than an individual parameter. We suggest that the homeostatic modulation of the physiological redox (PR) should be in focus, rather than the redox status parameter itself. It is further suggested that low molecular weight antioxidants (LMWA) are, in fact, rather insignificant concerning the PR maintenance, and that the major contributors to this delicate modulation are regulative, protein-based systems such as the protective phase II antioxidant enzymes. Moreover, we show that skin microbiome and cutaneous advanced lipid peroxidation end-products (ALEs) take part in sustaining the cutaneous PR homoeostasis via activation of the Nrf2–Keap1 protective pathway.

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Oxidative damage of human skin lipids

Cited by 29 publications

References 23 publications

Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy

Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy

Fatty acids, fatty acid analogues and their derivatives

The Cutaneous Physiological Redox: Essential to Maintain but Difficult to Define

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