Oxidative damage markers and antioxidants in patients with acute myocardial infarction and their clinical significance

Abstract

Oxidative stress has been associated with degenerative diseases such as cardiovascular and neurodegenerative diseases. Acute myocardial infarction (AMI) is the major cause of death among cardiovascular diseases. Inflammation, a major risk factor of AMI, is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and subsequent oxidant generation. It has been hypothesized that oxidative stress is a risk factor for AMI. To test this hypothesis, we studied profiles of oxidative damage and antioxidants in patients with AMI. The levels of MPO, 8-OHdG, and 3-Cl-Tyr were higher in blood specimens from AMI patients than in those of controls. Antioxidant levels, such as vitamin E and glutathione peroxidase, were significantly lower in these patients. The GSH/GSSG ratio, indicative of redox status, was also lower in AMI patients. Such findings suggest that these AMI patients experience increased oxidative stress. Moreover, markers in combination are better for evaluating antioxidant status and monitoring cardiac events than the same markers used separately.

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

“…This meta-analysis, by pooling together 14 studies enrolling 810 CVD patients and 1106 controls, has allowed to further address this issue. Moreover, two studies by Ho et al ( 14 ) and Kaya et al ( 19 ), not included in the present meta-analysis because they performed the evaluation of DNA damage in DNA extracted from white blood cell and expressed the ratio between 8-OHdG and 10 6 dG ( Supplementary Table S1 ), widely confirmed our results. When pooling together data from these two studies, we found higher levels of 8-OHdG in the 154 CAD patients than in the 97 controls (SMD: 1.79, 95% CI: 1.49–2.09, p < 0.001, I 2 : 0%, p = 0.45).…”

Oxidative Stress Markers in Young Patients with Acute Myocardial Infarction and Their Correlation with Cardiac Enzymes

“…Ho et al reported that the levels of the oxidative markers as 8-hydroxydeoxyguanosine (8-OHdG) and myeloperoxidase (MPO) were significantly higher and that the antioxidant capacity (measured as GPD and vitamin E) was significantly lower in patients with MI (17). In a recent study by Lo Presti et al, oxidant products were significantly higher, and antioxidant products were significantly lower in patients under 45 years old with AMI than in the control group (18).…”