Oxidative damage induced by chromium (VI) in rat erythrocytes: protective effect of selenium

Soudani, Nejla; Amara, Ibtissem Ben; Troudi, Afef; Hakim, Ahmed; Bouaziz, Hanen; Makni, F.; Zeghal, Khaled Mounir; Zeghal, Najiba

doi:10.1007/s13105-011-0104-4

Cited by 24 publications

(11 citation statements)

References 73 publications

(76 reference statements)

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“…Our findings revealed that short-term administration of methionine does not cause side effects on the ovary and its follicles even if used in high levels. In agreement with our results, several observations reported normal histology and correct structure and function of the ovaries in the presence of increased serum homocysteine (Soudani et al 2011;Al-Zamely et al 2001). Steegers-Theunissen et al (1992) showed a significant inverse relationship between follicular amounts of fluid homocysteine and oocyte and embryo quality in humans and suggested that the composition of follicular fluid mirrored metabolism of homocysteine in the body.…”

Section: Discussionsupporting

confidence: 93%

Effect of short-term administration of methionine on the ovary and uterus in a rat

et al. 2017

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Methionine is necessary for development but overuse of it can not only cause growth retardation but also damage organs such as the liver and cardiovascular system. The purpose of this research was to determine the effect of shortterm administration of methionine on the ovaries and uterus in a rat. Forty adult female rats were randomly allocated into four equal groups: each received 50, 100 or 200 mg/kg BW Lmethionine in 0.5 mL normal saline or just 0.5 mL normal saline (control) intraperitoneally for 20 days. On day 21, all rats were euthanized and tissues were taken for histological evaluation. Also, plasma homocysteine (Hcy) level was assessed in all groups. No difference was observed between the ovaries in all treatment and control groups; however, in methionine-injected groups, some histopathological changes were observed in the uterus such as atrophy in endometrial glands and the presence of inflammatory cells in the endo-and myometrium. Histopathological findings showed uterine infiltration of inflammatory cells in the methionine-injected groups which increased with increasing injected methionine levels. Also, all treatment groups showed increasing homocysteine levels compared to controls. These results show short-term administration of methionine and its associated homocysteinaemia has no effect on the ovary and its follicular structure.

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Section: Discussionsupporting

confidence: 93%

Effect of short-term administration of methionine on the ovary and uterus in a rat

et al. 2017

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“…In the present study, compared with the control treatment, 1.31 and 4.20 mg Se/kg treatment significantly decreased PC concentration in the hepatopancreas of abalone. The result is coincident with a previous study, in which Se significantly decreased PC concentration in rat erythrocytes after Cd exposure (Soudani et al., ). All the data above suggested that Se play sn important role in protecting hepatopancreas from oxidative damage induced by Cd.…”

Section: Discussionsupporting

confidence: 93%

Protective effects of dietary selenium on abaloneHaliotis discus hannaiagainst the toxicity of waterborne cadmium

Guo

Lei

et al. 2018

Aquac Res

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This study was conducted to investigate protective effects of dietary selenium (Se) on abalone Haliotis discus hannai Ino against the toxicity of cadmium (Cd). A 60-day feeding trial was conducted with abalone (initial weight: 3.17 ± 0.01 g), which were exposed to 0.34 mg/L of waterborne Cd. During a feeding trial, abalone were fed graded levels of Se at 0.10 (controls), 1.31, and 4.20 mg/kg diet respectively. Results showed that there was no significant difference in specific growth rate and survival rate of abalone among the three treatments. Compared with the controls, dietary Se significantly decreased Cd concentrations in serum, muscle, mantle, gill, mantle, and hepatopancreas of abalone. Besides, compared with the controls, dietary Se significantly increased metallothionein concentration in the hepatopancreas of abalone.Additionally, compared with the controls, dietary Se significantly decreased concentrations of malondiadehyde and protein carbonyl in hepatopancreas of abalone.Meanwhile, compared with the controls, dietary Se significantly increased activities of glutathione peroxidase, thioredoxin reductase, and thioredoxin peroxidase, and concentration of glutathione in the hepatopancreas of abalone. Based on the data above, in abalone, dietary Se showed protective effects against waterborne Cd. K E Y W O R D Sabalone, anti-oxidation, cadmium, Haliotis discus hannai, selenium, toxicity

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“…They are used in many industries as electroplating, leather tanning, and stainless-steel production (Yarkandi, 2014), but it is highly toxic causes multiorgan toxicity as hepatotoxicity, renal damage, and genotoxicity (Rana, 2008). Inside cells, Cr (VI) is reduced to Cr(III) by a variety of chemical reductants with production of reactive intermediates causing cellular damage and generation of reactive oxygen species (ROS) (Myers, 2012) that enhances oxidative stress and exert a cytotoxic effect and many diseases as renal disorders, liver disorders, inflammation and others (Soudani et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Hepatotoxicity, Nephrotoxicity, and Genotoxicity Induced by Acute Toxicity of Hexavalent Chromium and Comparison of the Possible Protective Role of Selenium and Vitamin E on These Effects

Hassan

Abdelwahab

Megahed

et al. 2019

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction Hexavalent chromium Cr (VI) is a strong oxidizing toxic agent. It penetrates cell membrane and quickly reduced with production of reactive intermediates and reactive oxygen species that react with the DNA causing anomalies in the cell structure. Vitamin E (vit. E) is a lipid soluble antioxidant preventing damage to membranes also selenium (Se) is an essential micronutrient with an antioxidant activity. Aim of the present study was to evaluate the hepatotoxicity, nephrotoxicity, and genotoxicity induced by acute Cr (VI) toxicity. Also, to evaluate and compare the possible protective role of vit. E and Se against that toxicity. Methodology: This study was carried out on 60 adult male albino rats divided into 10 rats of six groups, negative control group, selenium control group (0.5 mg/kg IP for 5 consecutive days), vitamin E control group (125 mg/kg orally for 14 days), Cr (VI) group (10 mg/kg single dose IP), Cr (VI) + Selenium group and hexavalent chromium + Vitamin E group. Liver and kidney function tests, total protein, oxidative stress, antioxidant markers and genotoxic analysis were done to all groups. Result: Acute Cr(VI) toxicity resulted in increased levels of the studied liver, kidney , oxidative stress markers, all forms of chromosomal aberrations and elevation of DNA damage. It decreased levels of total protein and antioxidant markers. Treatment with Se or vit. E resulted in improvement in all these effects. Conclusion& recommendation: Cr (VI) is a hepatotoxic, nephrotoxic, and genotoxic. Se or vit. E has the ability for reduction of these deleterious effects. So it is recommended to do regular medical examination of workers exposed to hexavalent chromium for early detection of any health problem and afford dietary supplementation with vitamin E and selenium.

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Oxidative damage induced by chromium (VI) in rat erythrocytes: protective effect of selenium

Cited by 24 publications

References 73 publications

Effect of short-term administration of methionine on the ovary and uterus in a rat

Effect of short-term administration of methionine on the ovary and uterus in a rat

Protective effects of dietary selenium on abaloneHaliotis discus hannaiagainst the toxicity of waterborne cadmium

An Evaluation of Hepatotoxicity, Nephrotoxicity, and Genotoxicity Induced by Acute Toxicity of Hexavalent Chromium and Comparison of the Possible Protective Role of Selenium and Vitamin E on These Effects

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