Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

Seet, Raymond C.S.; Lee, Jetty Chung‐Yung; Lim, Erle C.H.; Tan, June J.H.; Quek, Amy M.L.; Chong, Wan-Ling; Looi, Woan-Foon; Huang, Shan-Hong; Wang, Huansong; Chan, Yiong‐Huak; Halliwell, Barry

doi:10.1016/j.freeradbiomed.2009.11.026

Cited by 230 publications

(147 citation statements)

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“…Oxidative stress is characterized by a redox imbalance between generation of free radicals or other reactive species and antioxidant defenses, and it may be related to changes in mitochondrial function and protein clearance [82]. There is considerable evidence for involvement of mitochondrial dysfunction in sporadic PD, since multiple genes in which mutations or polymorphisms increase the risk of PD, are linked to mitochondrial function [83].…”

Section: Oxidative Stress In Sporadic Pdmentioning

confidence: 99%

See 1 more Smart Citation

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito

Cunha‐Oliveira

Rego

2012

Free Radical Biology and Medicine

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Section: Oxidative Stress In Sporadic Pdmentioning

confidence: 99%

“…Lipid and DNA oxidation were also found to be systemically elevated in PD [82]. Oxidative and nitrative posttranslational modifications have been identified on proteins that may affect the disease progression [81].…”

Section: Oxidative Stress In Sporadic Pdmentioning

confidence: 99%

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito

Cunha‐Oliveira

Rego

2012

Free Radical Biology and Medicine

View full text Add to dashboard Cite

“…The nucleic acid oxidation product 8-hydroxyguanosine is also elevated in the neurons affected in the disease, compared to surrounding brain regions in the PD brain, as well as in comparison to the SN of age-matched controls [87,88]. Lipid and DNA oxidation was also found to be systemically elevated in PD [82]. Oxidative and nitrative posttranslational modifications have been identified on proteins that may affect the disease progression [81].…”

Section: Oxidative Stress In Sporadic Pdmentioning

confidence: 98%

“…Oxidative stress is characterized by a redox imbalance between the generation of free radicals or other reactive species and antioxidant defenses, and it may be related to changes in mitochondrial function and protein clearance [82]. There is considerable evidence for the involvement of mitochondrial dysfunction in sporadic PD, because multiple genes for which mutations or polymorphisms increase the risk of PD are linked to mitochondrial function [83].…”

Section: Oxidative Stress In Sporadic Pdmentioning

confidence: 99%

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito

Cunha‐Oliveira

Rego

2013

Free Radical Biology and Medicine

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a b s t r a c tParkinson disease (PD) is a chronic and progressive neurological disease associated with a loss of dopaminergic neurons. In most cases the disease is sporadic but genetically inherited cases also exist. One of the major pathological features of PD is the presence of aggregates that localize in neuronal cytoplasm as Lewy bodies, mainly composed of a-synuclein (a-syn) and ubiquitin. The selective degeneration of dopaminergic neurons suggests that dopamine itself may contribute to the neurodegenerative process in PD. Furthermore, mitochondrial dysfunction and oxidative stress constitute key pathogenic events of this disorder. Thus, in this review we give an actual perspective to classical pathways involving these two mechanisms of neurodegeneration, including the role of dopamine in sporadic and familial PD, as well as in the case of abuse of amphetamine-type drugs. Mutations in genes related to familial PD causing autosomal dominant or recessive forms may also have crucial effects on mitochondrial morphology, function, and oxidative stress. Environmental factors, such as MPTP and rotenone, have been reported to induce selective degeneration of the nigrostriatal pathways leading to a-syn-positive inclusions, possibly by inhibiting mitochondrial complex I of the respiratory chain and subsequently increasing oxidative stress. Recently, increased risk for PD was found in amphetamine users. Amphetamine drugs have effects similar to those of other environmental factors for PD, because long-term exposure to these drugs leads to dopamine depletion. Moreover, amphetamine neurotoxicity involves a-syn aggregation, mitochondrial dysfunction, and oxidative stress. Therefore, dopamine and related oxidative stress, as well as mitochondrial dysfunction, seem to be common links between PD and amphetamine neurotoxicity.

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“…Moreover, markers of oxidative damage in PD patients were also detected in the serum and urine [132][133][134][135], but their use as indicators of the course of the disease is far from being useful for clinical practice because the existing data are contradictory [136][137][138]. As has been suggested [136][137][138], these differences may be due to the variability in methods used to measure OS markers.…”

Section: Clinical Studies Oxidative Biomarkersmentioning

confidence: 99%