Oxidative damage and antioxidant defense in thymus of malnourished lactating rats

Gavia-García, Graciela; González-Martínez, Haydeé; Miliar-García, Ángel; Bonilla-González, Edmundo; Rosas-Trejo, María de los Ángeles; Königsberg, Mina; Nájera-Medina, Oralia; Luna–López, Armando; González-Torres, María Cristina

doi:10.1016/j.nut.2015.05.014

Cited by 12 publications

(8 citation statements)

References 49 publications

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“…ATI is a common and well-known feature in various fungal Mendes-Giannini et al 2008;Souto et al 2003), viral (Duan et al 2015;Falkenberg et al 2014;Gao et al 2015) and bacterial infectious diseases (LeyvaRangel et al 2015;Ross et al 2012;Savino 2006). ATI can also be caused by immune suppression (Billard et al 2011;Zhou et al 2016), hunger (Gavia-García et al 2015;Savino et al 2007), chemotherapy, radiography (DeBo et al 2015;Lynch et al 2009), pregnancy (Ekin et al 2016;Jacques et al 2014Jacques et al , 2015, transplant rejection (Gracia-Ahufinger et al 2015;Krenzien et al 2015) and other severe disease conditions (Wang et al 2016). ATI in certain physiological conditions (e.g., during malnutrition and pregnancy) is usually mediated by the neuroendocrine system, and the transient thymic regression is characterized by increased thymocyte death, with the capability to recuperate after the removal of the insult (Gruver and Sempowski 2008;Shanley et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Acute Thymic Involution and Mechanisms for Recovery

Ansari

Liu

2017

Arch. Immunol. Ther. Exp.

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Section: Introductionmentioning

confidence: 99%

Acute Thymic Involution and Mechanisms for Recovery

Ansari

Liu

2017

Arch. Immunol. Ther. Exp.

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“…Although thymic atrophy is one of the most notorious features in malnourished organisms, there are other alterations in this organ, such as decreased cell proliferation, increased apoptosis, together with alterations in antioxidant defense mechanisms. 6 , 9 Here, a thymus deficit and body weight in MN rats were observed in the NT and t-BHQ-treated groups compared to their respective WN groups. These weight deficits were notable in MN3 independently of treatment.…”

Section: Discussionmentioning

confidence: 80%

“…Experimental MN was induced during lactation by food competition, based on reducing the quantity of milk/pup by increasing the number of pups per nursing mother, 17 as we described previously. 9 All experimental groups (Well-nourished [WN] and MN) received 3 t-BHQ (75 mg/kg/d) doses dissolved in saline solution and administrated intraperitoneally (IP) from day 18 until day 20. Control (nontreated; NT) groups (WN and MN) received only saline solution.…”

Section: Methodsmentioning

confidence: 99%

“…6,7 Besides, MN has been linked to a deficient antioxidant defense system 8 and increased DNA and lipid oxidative damage. 9 It has been reported that in children with severe malnutrition have lower blood concentrations of Reduced glutathione (GSH) 10 along with increased malondialdehyde (MDA) levels. 8 Accordingly, there is considerable interest in developing therapeutic strategies to prevent oxidative damage and restoring antioxidant mechanisms in malnourished organisms.…”

Section: Introductionmentioning

confidence: 99%

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t-BHQ Protects Against Oxidative Damage and Maintains the Antioxidant Response in Malnourished Rats

et al. 2018

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Objective:Tert-butylhydroquinone (t-BHQ) protective effect against oxidative damage in thymus from malnourished pops-rats was evaluated.Methods:Malnutrition in pops-rats was induced during the lactation period and first-, second-, and third-degree malnourished rats were studied (MN1, MN2, and MN3). To determine t-BHQ protective effect, lipid peroxidation (LPx) was assessed, as well as the carbonyl content. The reduced glutathione and glutathione disulfide content were determined and antioxidant enzyme activities were measured.Results:Oxidative protein damage, LPx, and Nuclear Factor-κB (NF-κB) content, increased in the MN2 and MN3 compared to well-nourished rats, associated with lower protein content and antioxidant activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase. Tert-butylhydroquinone treatment induced a protective effect against lipids and proteins oxidative damage, as well as decrease in NF-κB in MN rats and restored the antioxidant mechanisms, mostly GPx and SOD. No differences were found between male and female animals.Conclusions:Results show that higher body weight deficit leads to increased oxidative damage and probably inflammation, attributable to alterations in antioxidant mechanisms. These effects were reversed by the t-BHQ-treatment, which restores the antioxidant response. Our findings suggest that t-BHQ could be an interesting pharmacological intervention, but it needs to be studied further.

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“…The damages caused by oxidative stress have been related to malnutrition, which could alter the antioxidant protection mechanisms [23]. Normally, organisms are equipped with mechanisms to eliminate these reactive species, involving both nonenzymatic and enzymatic pathways.…”

Section: Discussionmentioning

confidence: 99%

Oral Kefir Grains Supplementation Improves Metabolism and Liver Antioxidant Enzymes Expression in Malnourished Mice

FR¹,

AS²,

DF³

et al. 2020

Austin J Nutri Food Sci

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Scope: This study has a novel approach to investigate the effects of oral supplementation of kefir grains on metabolic improvement and the expression of the antioxidant enzymes Glutathione Peroxidase (GPx) and Catalase (CAT) of the liver in malnourished mice. Method and Results: Swiss mice were divided into four groups and subjected to two treatment phases: the food restriction phase of 20% in relation to the control group was maintained until animals reached a weight deficit of about 20% in relation to their original weight and the renutrition phase, the animals received diets every day for 30 days. Diets (chow powder plus kefir grains) were administered orally. Thereafter, during throughout the experiment measurements of body weight and energy consumption were obtained. After the end of treatment, fasting glucose tolerance tests were performed at night and insulin sensitivity with fed mice. Soon in then, the mice were euthanized by beheading in guillotine and the blood and liver were collected for evaluation of biochemical parameters, Histopathological assessments and Reverse transcriptase (RT-PCR). Conclusion: The present study demonstrated the kefir grains ability to modulate inflammation and hepatic oxidative-stress under malnourished-state. Keywords: Food Restriction; Malnutrition; Hepatic; Oxidative Stress; Nutrition

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Oxidative damage and antioxidant defense in thymus of malnourished lactating rats

Cited by 12 publications

References 49 publications

Acute Thymic Involution and Mechanisms for Recovery

Acute Thymic Involution and Mechanisms for Recovery

t-BHQ Protects Against Oxidative Damage and Maintains the Antioxidant Response in Malnourished Rats

Oral Kefir Grains Supplementation Improves Metabolism and Liver Antioxidant Enzymes Expression in Malnourished Mice

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