“…Pumiliotoxin B (77) shows powerful cardiotonic and myotonic activity, which is believed to involve calcium-dependent mechanisms [44]. …”
Section: Pharmacological Propertiesmentioning
confidence: 99%
“…Tracer experiments showed that the phenolic oxidation of lophocerine (131, racemic mixture) by enzymes in the plant furnishes pilocereine (130) [77], [78]. This coupling process was reproduced in the laboratory by potassium ferricyanide oxidation of 131 at pH 6 [79].…”
“…Pumiliotoxin B (77) shows powerful cardiotonic and myotonic activity, which is believed to involve calcium-dependent mechanisms [44]. …”
Section: Pharmacological Propertiesmentioning
confidence: 99%
“…Tracer experiments showed that the phenolic oxidation of lophocerine (131, racemic mixture) by enzymes in the plant furnishes pilocereine (130) [77], [78]. This coupling process was reproduced in the laboratory by potassium ferricyanide oxidation of 131 at pH 6 [79].…”
“…[3][4][5] A plethora of biosynthetic pathways involve phenol reactivity, especially oxidative coupling of these species. [6][7][8][9] As a result, developing oxidative phenolic coupling methods has remained an important challenge in organic chemistry. 10,11 Fig.…”
This review highlights modern uses of oxidative phenol coupling in the total synthesis of natural products, spanning catalytic, electrochemical, stoichiometric and enzymatic approaches.
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