Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Defining Body Weight

Nowicki, Grzegorz; Ślusarska, Barbara; Prystupa, Andrzej; Polak, Maciej; Czubaj-Kowal, Marta; Rudnicka–Drożak, Ewa

doi:10.3390/ijerph16214077

Cited by 4 publications

(4 citation statements)

References 80 publications

(87 reference statements)

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“…OSI is the percentage ratio of TOS to TAC. In a study by Nowicki et al, in which people after cardiovascular events (study group) and those without a history of cardiovascular events (control group) participated, no significant difference was found in OSI between the research and the control group, as well as no significant correlation was found between OSI and BMI [ 45 ]. Our study also showed no significant difference in terms of OSI between the MUO, MHO, and MHNW groups.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Jakubiak

Osadnik

Lejawa

et al. 2021

Oxidative Medicine and Cellular Longevity

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Introduction. Obesity is one of the most important public health problems in the world. Among obese people, there are those who, apart from excessive body weight, do not exhibit other metabolic dysfunctions, have a lower risk of developing cardiovascular diseases (CVDs), and show lower mortality. According to the theory, they are referred as metabolically healthy obese (MHO), in contrast to metabolically unhealthy obese (MUO). Metabolic disturbances occurring with obesity have been well established to be associated with oxidative stress. Aim. The purpose of this study was to analyse the association between selected anthropometric and biochemical parameters with oxidative stress in MHO, MUO, and normal weight young adults. Material and Methods. Individuals with age between 18 and 36 years with no history of chronic diseases and use of medicaments, with or without obesity, participated in the study. Complete blood counts, biochemical measurements, and parameters of oxidative stress such as total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), serum concentration of malondialdehyde (MDA), ceruloplasmin, thiol groups and lipid hydroperoxides (LPH), concentration of lipofuscin (LPS) in erythrocytes, and the activity of superoxide dismutase (SOD) were measured. Results. 422 patients who met the inclusion criteria were enrolled in the study. Among the study participants, 208 people (49.29%) were offspring of patients with angiographically confirmed coronary artery disease. Among the participants, 16 patients have been included in the group of metabolically healthy obese (MHO) people and 61 patients in the group of metabolically unhealthy obese (MUO) people and 345 patients had normal body weight. Significant differences between metabolically unhealthy obese and normal weight patients, as well as between women and men, have been found. Conclusions. We showed significant differences in the selected parameters of oxidative stress between metabolically unhealthy obese (MUO) individuals and young volunteers with normal body weight as well as without significant medical history.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Jakubiak

Osadnik

Lejawa

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…In this regard, young smokers diagnosed with acute myocardial infarction, had significantly higher OSI and TOS levels and lower TAS and LOOH levels. Moreover, CAD severity correlated positively with OSI and TOS levels, suggesting that high levels of OSI and TOS could be considered as indicators of disease severity and heavy smoking-related vascular damage in early-onset CAD [119,157]. Finally, Frati et al showed that smokers had an increase in oxidative stress markers and a worsening of antioxidant systems compared to non-smoker [161] (Table2).…”

Section: Smokingmentioning

confidence: 98%

“…Hypertension is one of the most common cardiovascular risk factors, and oxidative stress is important in the molecular mechanisms associated with it [162]. Oxidative stress was observed among hypertensive patients as depicted by the high plasma levels of oxLDL [107,114,119], and reduced enzymatic antioxidant activity, which is determined by glutathione peroxides (GPx) [110,114], total antioxidant capacity (TAOC) [113], ferric reducing ability of plasma (FRAP) [113], total antioxidant capacity (TAC) [115,119]. There are many studies focusing on the comparison of oxidative stress biomarkers in hypertensive patients.…”

Section: Hypertensionmentioning

confidence: 99%

The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

et al. 2021

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Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

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“…21,24 The relation between BMI and oxidative stress has been reported. 25,26 Low-density lipoprotein-cholesterol-C level is not a criterion for MetS and is not necessarily elevated in MetS patients, 27 but risk is further increased by elevated LDL-C in patients with MetS. 28 In the present study, LDL-C levels were significantly higher in the MetS group than in the controls.…”

Section: Discussionmentioning

confidence: 45%

Differences Between Morbid Obesity With Metabolic Syndrome and Overweight Turkish Adult Participants in Multiple Atherosclerotic Cardiovascular Disease Risk Factors

2020

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Obesity and metabolic syndrome (MetS) are public health problems and are increasing globally. We assessed the differences in lipid profiles through lipid testing, thrombotic and inflammatory parameters, and oxidative stress indexes between overweight and obese patients with MetS in a Turkish adult population. We included 100 obese (body mass index [BMI] >30 kg/m2) patients with MetS (66 women, 34 men, mean age 54.0 ± 10.1 years) and 15 overweight (BMI 25-30 kg/m2) individuals (11 women, 4 men, mean age 50.2 ± 14.5 years) as controls. The group with MetS had significantly higher levels of glycaemia, uric acid, high-sensitivity C-reactive protein, homocysteine, fibrinogen, total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, small dense LDL, oxidized LDL, apolipoprotein B (Apo B), lipoprotein (a), small and intermediate high-density lipoprotein (HDL) particles, oxidative stress index, and significantly lower levels of HDL-cholesterol (HDL-C), Apo A, and large HDL particles. In conclusion, obesity with MetS increase atherogenic dyslipidemia and thrombotic, inflammatory and oxidative stress biomarkers. Furthermore, obesity with MetS decreases protective mechanisms of atherosclerosis. We should at least try to prevent overweight individuals from becoming obese with MetS.

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Oxidative/Antioxidative Status in Patients after Myocardial Infarction and in Those without Cardiovascular Event Depending on Anthropometric Factors Defining Body Weight

Cited by 4 publications

References 80 publications

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Differences Between Morbid Obesity With Metabolic Syndrome and Overweight Turkish Adult Participants in Multiple Atherosclerotic Cardiovascular Disease Risk Factors

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