Oxidative and Nitrosative Stress in Stable Renal Transplant Recipients with Respect to the Immunosuppression Protocol – Differences or Similarities? / Oksidativni I Nitrozativni Stres U Odnosu Na Imunosupresivni Protokol Kod Pacijenata Sa Stabilnom Funkcijom Presađenog Bubrega – Razlike I Sličnosti

Cvetković, Tatjana; Veličković‐Radovanović, Radmila; Stojanović, Dijana; Stefanović, Nikola; Ignjatović, Aleksandra; Stojanović, Ivana; Sladojević, Nikola; Pavlović, Dušica

doi:10.2478/jomb-2014-0047

Cited by 9 publications

(6 citation statements)

References 61 publications

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“…In this study, we failed to find some statistically significant differences in parameters of oxidative stress status between CKD patients and PT patients ( Table II ). This result is in agreement with previous researches, were general conclusion could be that even kidney transplantation is the ideal treatment for patients with end-stage kidney disease, the intensive oxidative stress is still one of the biggest problem for those patients and probably the major molecular mediator of adverse outcomes throughout the course of transplantation (25). Also, due to the fact that oxidative stress affect both short-term and long-term survival of PT patients different prophylactic approaches should be employed in order to reduce oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

“…But, even results of our study generally didn't showed some significant changes in oxidative status parameters, very important finding of this study was markedly higher concentration of MPO in CKD patients then in PT subjects ( Table II ), although with borderline significance. It has been previously demonstrated that MPO, as a link between oxidative stress and inflammation, was elevated in CKD (25). Our results imply differences in level of MPO in CKD and after dialysis, which should be tested in larger samples.…”

Section: Discussionmentioning

confidence: 99%

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Alterations of HDL Particles in Children with End-Stage Renal Disease

Stefanović

Ristovski-Kornic

Kotur‐Stevuljević

et al. 2017

Journal of Medical Biochemistry

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SummaryBackground: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality are

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Alterations of HDL Particles in Children with End-Stage Renal Disease

Stefanović

Ristovski-Kornic

Kotur‐Stevuljević

et al. 2017

Journal of Medical Biochemistry

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“…Some studies reported that increased levels of malondialdehyde are a consequence of immunosuppressive therapy and that OS is induced mostly by cyclosporine A [ 147 , 148 ]. Other studies, however, have not confirmed these findings [ 140 , 149 , 150 ]. Other factors, such as opportunistic infection or immune response to allograft, may also trigger OS in kidney transplant recipients [ 151 ].…”

Section: Uremic Toxins and Kidney Functionmentioning

confidence: 82%

Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation

Wojtaszek

Ołdakowska‐Jedynak

Kwiatkowska

et al. 2021

Oxidative Medicine and Cellular Longevity

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Patients with chronic kidney disease (CKD) are at a high risk for cardiovascular disease (CVD), and approximately half of all deaths among patients with CKD are a direct result of CVD. The premature cardiovascular disease extends from mild to moderate CKD stages, and the severity of CVD and the risk of death increase with a decline in kidney function. Successful kidney transplantation significantly decreases the risk of death relative to long-term dialysis treatment; nevertheless, the prevalence of CVD remains high and is responsible for approximately 20-35% of mortality in renal transplant recipients. The prevalence of traditional and nontraditional risk factors for CVD is higher in patients with CKD and transplant recipients compared with the general population; however, it can only partly explain the highly increased cardiovascular burden in CKD patients. Nontraditional risk factors, unique to CKD patients, include proteinuria, disturbed calcium, and phosphate metabolism, anemia, fluid overload, and accumulation of uremic toxins. This accumulation of uremic toxins is associated with systemic alterations including inflammation and oxidative stress which are considered crucial in CKD progression and CKD-related CVD. Kidney transplantation can mitigate the impact of some of these nontraditional factors, but they typically persist to some degree following transplantation. Taking into consideration the scarcity of data on uremic waste products, oxidative stress, and their relation to atherosclerosis in renal transplantation, in the review, we discussed the impact of uremic toxins on vascular dysfunction in CKD patients and kidney transplant recipients. Special attention was paid to the role of native and transplanted kidney function.

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“…This seemingly contradictory finding is in line with some but not all observations made in other clinical settings. 27,28…”

Section: Discussionmentioning

confidence: 99%

Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation

et al. 2018

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Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft- versus -host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant serum levels of asymmetric dimethylarginine on outcome after allogeneic stem cell transplantation. Since acute graft- versus -host disease and its treatment are major contributors to post-transplant mortality, the effect of asymmetric dimethylarginine on outcome measures was also assessed after onset of acute graft- versus -host disease. A total of 938 patients allografted at two centers between 2002 and 2013 were included in the retrospective study. In multivariable models, higher pre-transplant asymmetric dimethylarginine levels were significantly associated with an increased risk of non-relapse mortality (hazard ratio 1.43 per 1-log 2 increase, P =0.005) but not with relapse (hazard ratio 1.21, P =0.109) within the first year after transplantation. This translated into worse overall survival (hazard ratio 1.45, P <0.0001) and shorter progression-free survival (hazard ratio 1.30, P =0.002) in the first year after transplantation. Higher pre-transplant asymmetric dimethylarginine levels were also associated with shorter overall survival (hazard ratio 1.46, P =0.001) and progression-free survival (hazard ratio 1.32, P =0.010) and higher non-relapse mortality (hazard ratio 1.36, P =0.042) within 1 year after the onset of acute graft- versus -host disease. Taken together, our data indicate an association between pre-transplant asymmetric dimethylarginine status and early non-relapse mortality in allografted patients, both overall and after the onset of acute graft- versus -host disease. These findings underline the relevance of endothelial dysfunction for transplant complications.

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Cited by 9 publications

References 61 publications

Alterations of HDL Particles in Children with End-Stage Renal Disease

Alterations of HDL Particles in Children with End-Stage Renal Disease

Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation

Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation

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