Oxidative and Epigenetic Changes and Gut Permeability Response in Early-Treated Chickens with Antibiotic or Probiotic

Abstract

The aim of this study was to compare the effect of the use of enrofloxacin and a probiotic containing Enterococcus faecium and Bacillus amyloliquefaciens strains in the first week of life of chickens on oxidative and epigenetic changes in molecules and intestinal integrity. The three treatments were as follows: the control group received no additive in the drinking water (GC); the second group (GP) received a probiotic preparation in the drinking water during the first five days of life, providing E. faecium strain 4a1713 at 1.0 × 107 CFU/L water and B. amyloliquefaciens 4b1822 at 1.0 × 107 CFU/L water, the third group (GA) received an antibiotic (enrofloxacin 0.5 mL/L water) in the drinking water during the first five days of life. The use of both enrofloxacin and a probiotic containing E. faecium and B. amyloliquefaciens strains in chickens’ first week of life improved intestinal integrity and reduced inflammation and oxidative and epigenetic changes in the small intestine. This effect was evident both at 6 days of age and at the end of the rearing period.

Influence of phytobiotics and organic acid on nutrient utilization efficiency and carcass characteristics of broiler

“…So, it is very important to search a new alternative to synthetic antibiotic growth promoters and in that situation, phytogenic feed additive could be one of the best solutions *Abdullah Al Sufian SHUVO 1 , Atiar Md RAHMAN 2 1 Bangladesh Agricultural University, Animal Nutrition, Mymensingh, Bangladesh 2 Shinshu University, Department of Bio-Science and Food Production, Minami Minowa, Nagano, Japan (Ghalamkari et al, 2012;David et al, 2016). Moreover, phytogenic feed additives are non-toxic, natural, free from residual effects (El-Hack et al, 2020;Magdalena et al, 2021) and also enhance digestibility by stimulating the digestive enzyme secretion, boosting up immunity as well as show antiviral effects (Oh et al, 2013;Ognik et al, 2020). Non-nutritive feed additives like antibiotics used in sub therapeutic level in animal production create antimicrobial resistance in human due to the production of residues in animal products (Durrani et al, 2008).…”

The Effect of Administration of a Phytobiotic Containing Cinnamon Oil and Citric Acid on the Metabolism, Immunity, and Growth Performance of Broiler Chickens

“…Phytobiotic materials can be herbal extracts or plant parts (leaves, rhizomes, roots, flowers, bark, or, less commonly, seeds) with the greatest accumulation of bioactive substances. Phytobiotic additives can stimulate the appetite, increase secretion of digestive enzymes, stimulate immunity, and exert bactericidal, antiviral, and antioxidant effects, as well as improve growth performance and the quality of animal products [ 4 , 5 , 6 ].…”

INFLUENCE OF ANTIBIOTICS, GLYPHOSATE AND A Bacillus sp. STRAIN ON PRODUCTIVITY PERFORMANCE AND GENE EXPRESSION IN CROSS ROSS 308 BROILER CHICKENS (Gallus gallus L.)

“…Поиск средств, положительно влияющих на микробиоту кишечника птицы за счет стимуляции защитных механизмов и снижения потребности в профилактическом и терапевтическом применении антибиотиков, ведется в течение многих лет. Полезные штаммы микроорганизмов, несомненно, занимают первое место среди таких агентов (27)(28)(29) и находят широкое применение в кормлении сельскохозяйственной птицы (30). Нередко полезные бактерии применяются одновременно с антибиотиками для профилактики побочных эффектов последних (31).…”