Oxidative and DNA damage in obese patients undergoing bariatric surgery: A one-year follow-up study

Chiaramonte, Anna; Testi, Serena; Pelosini, Caterina; Micheli, Consuelo; Falaschi, Aurora; Ceccarini, Giovanni; Santini, Ferruccio; Scarpato, Roberto

doi:10.1016/j.mrfmmm.2023.111827

Cited by 1 publication

(1 citation statement)

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“…It was accompanied by a decrease in DNA damage (54% decrease; DNA damage assessed by the comet assay). A fall in DNA damage (assessed by measurement of gH2AX foci indicating the presence of DNA double strand breaks in the nuclei) was also observed 12 months after bariatric surgery in a group of 49 adult patients [9]. The DNA damage was 21-fold higher in patients with obesity than in controls, but showed a substantial reduction over the three time points (1, 6, 12 months) of the postoperatory follow-up with 20, 34, and 49% lower values compared with preoperative condition.…”

Section: Key Pointsmentioning

confidence: 89%

DNA damage, obesity and obesity-related health complications: what are new data telling us?

Włodarczyk,

Nowicka

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Obesity is associated with increased DNA damage, which may in turn contribute to the development of obesity-related complications. DNA damage can also affect adipocyte biology, resulting in increased adiposity. Carefully managed weight loss programs can reverse this process. This article surveys new data that support these contentions. Recent findings Whole exome sequencing analyses have identified rare variants linked to high BMI and adiposity. Two of the identified genes are linked to DNA damage and DNA repair, suggesting that DNA damage itself may play a role in the cause of obesity. It has also been recognized that obesity increases DNA damage in breast tissue of carriers of BRCA mutations and rates of tumour formation in BRCA1+ mice, indicating effect of obesity on cancer development in high-risk populations. In addition, obesity promotes cancer cell chemoresistance by decreasing fatty acid oxidation involved in cellular DNA damage response, leading to apoptotic cellular death. Obesity is also associated with a reduced capacity of oocytes to repair sperm DNA damage, leading to lower in-vitro fertilization rates in women with obesity. Summary DNA damage and cellular responses to DNA damage can be both the result and the cause of obesity and can strongly influence the development and treatment of obesity-associated diseases.

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Section: Key Pointsmentioning

confidence: 89%