Oxidative and carbonyl stress in pregnant women with obstructive sleep apnea

Khan, Nazia; Lambert‐Messerlian, Geralyn; Hodosy, Július; Tóthová, Ľubomíra; Celec, Peter; Eklund, Elizabeth; Curran, Patrizia; Bourjeily, Ghada

doi:10.1007/s11325-017-1475-8

Cited by 19 publications

(10 citation statements)

References 46 publications

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“…8-Hydroxy-2-deoxyguanosine (8-OHdG) is a product derived from the oxidation of deoxyribonucleic acid (DNA) used in the literature to evaluate oxidative stress damage [ 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. Several studies have reported a correlation between the severity of OSAS and 8-OHdG, as well as the total antioxidant capacity (TAC) [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Maniaci

Iannella

Cocuzza

et al. 2021

JCM

130

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Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory sleep disorder characterised by repeated episodes of partial or complete obstruction of the upper airway during the night. This obstruction usually occurs with a reduction (hypopnea) or complete cessation (apnea) of the airflow in the upper airways with the persistence of thoracic-diaphragmatic respiratory movements. During the hypopnea/apnea events, poor alveolar ventilation reduces the oxygen saturation in the arterial blood (SaO2) and a gradual increase in the partial arterial pressure of carbon dioxide (PaCO2). The direct consequence of the intermittent hypoxia is an oxidative imbalance, with reactive oxygen species production and the inflammatory cascade’s activation with pro and anti-inflammatory cytokines growth. Tumour necrosis factors, inflammatory cytokines (IL2, IL4, IL6), lipid peroxidation, and cell-free DNA have been found to increase in OSAS patients. However, even though different risk-related markers have been described and analysed in the literature, it has not yet been clarified whether specified inflammatory bio-markers better correlates with OSAS diagnosis and its clinical evolution/comorbidities. We perform a scientific literature review to discuss inflammatory and oxidative stress biomarkers currently tested in OSAS patients and their correlation with the disease’s severity and treatment.

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Section: Resultsmentioning

confidence: 99%

“…Several studies have reported a correlation between the severity of OSAS and 8-OHdG, as well as the total antioxidant capacity (TAC) [ 68 ]. Moreover, urinary excretion (8-OHdG) has been positively correlated in patients with OSAS [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Maniaci

Iannella

Cocuzza

et al. 2021

JCM

130

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“…69,70 However, preliminary data show flattening, rather than activation, of the cortisol awakening response. 59 Other potential mechanisms include an enhanced inflammatory profile, endothelial dysfunction, and oxidative stress but remain to be proven; recent data, however, suggest that oxidative stress may not be implicated 71 given potential downregulation by estradiol. 23 The allostatic load hypothesis has also been proposed, suggesting that chronic sleep loss is both a precipitant of stress as well as a consequence of it, leading to a stress "overload" that may account for adverse pregnancy outcomes.…”

Section: Sleep In Pregnancymentioning

confidence: 99%

Sleep in Women Across the Life Span

Pengo

Won

Bourjeily

2018

Chest

Self Cite

194

133

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There are many ways in which women experience sleep differently from men. Women contending with distinct sleep challenges respond differently to sleep disorders, as well as sleep deprivation and deficiency, and face particular health outcomes as a result of poor sleep. Idiosyncrasies, including changes that occur with the biological life cycles of menstruation, pregnancy, and menopause, make the understanding of sleep in women an important topic to study. Each phase of a woman's life, from childhood to menopause, increases the risk of sleep disturbance in unique ways that may require distinct management. Indeed, new research is unraveling novel aspects of sleep pathology in women and the fundamental role that sex hormones play in influencing sleep regulation and arousals and possibly outcomes of sleep conditions. Moreover, studies indicate that during times of hormonal change, women are at an increased risk for sleep disturbances such as poor sleep quality and sleep deprivation, as well as sleep disorders such as OSA, restless legs syndrome, and insomnia. This article reviews sleep changes in female subjects from neonatal life to menopause.

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“…Khan et al conducted a case-controlled analysis of serum markers of oxidative stress and antioxidant capacity in women with OSA in pregnancy and, contrary to their hypotheses, found that the pregnant women with OSA had a significantly greater antioxidant capacity and lower oxidative and carbonyl stress markers than controls. [68]…”

Section: The Pathogenesis Of Osa and Hypertensive Disorders Of Pregnancymentioning

confidence: 99%

A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease

Dominguez¹,

Habib²,

Krystal

2018

Sleep Medicine Reviews

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Obesity is prevalent among pregnant women in the United States; 15-20% of obese pregnant women have obstructive sleep apnea. The prevalence of obstructive sleep apnea increases along with body mass index, age and in the presence of other co-morbidities. Untreated obstructive sleep apnea in women is associated with a range of cardiovascular, pulmonary and metabolic co-morbidities; recent studies suggest that women with obstructive sleep apnea in pregnancy may be at significantly greater risk of entering pregnancy with chronic hypertension and/or of developing hypertensive disorders of pregnancy: gestational hypertension; preeclampsia; or eclampsia. This has serious public health implications; hypertensive disorders of pregnancy are a major cause of maternal and neonatal morbidity and mortality and are associated with a greater lifetime risk for cardiovascular disease. The mechanisms that associated obstructive sleep apnea with hypertensive disorders of pregnancy have not been defined, but several pathways are scientifically plausible. In this review, we will present a comprehensive literature review of the following: the associations between obstructive sleep apnea and hypertensive disorders of pregnancy; the proposed mechanisms that may connect obstructive sleep apnea and hypertensive disorders of pregnancy; and the effectiveness of treatment at mitigating these adverse outcomes.

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Oxidative and carbonyl stress in pregnant women with obstructive sleep apnea

Cited by 19 publications

References 46 publications

Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Sleep in Women Across the Life Span

A review of the associations between obstructive sleep apnea and hypertensive disorders of pregnancy and possible mechanisms of disease

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