Oxidative ammonolysis of 2-methylquinoxaline on vanadium-titanium oxide catalyst

Postnikov, L. S.; Korovina, I. V.; Кагарлицкий, А. Д.; Krichevskii, L. A.

doi:10.1134/s1070427208020316

Cited by 4 publications

(5 citation statements)

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“…Measurements were made with pyknometer. Postnikov [28] reported the densities of Na 2 CO 3 (aq) at saturation from 293 to 343 K. The uncertainty of the measurements is 0.01%. Only one dataset at high pressures reported by Correia and Kestin [40] for Na 2 CO 3 (aq) was found in the literature.…”

Section: Experiments Density Datamentioning

confidence: 98%

“…Measurements were performed by means of a capillary flow method with an uncertainty of 0.5%. Postnikov [28] also measured the viscosity of Na 2 CO 3 (aq) at saturation at temperatures from 293 to 343 K. Zaytsev and Aseyev [46] correlated available experimental viscosity data for Na 2 CO 3 (aq) solutions in the temperature range from 273 to 373 K and at concentrations from 0.19 to 3.33 mol kg −1 at atmospheric pressure. Most reported experimental data on the viscosity of Na 2 CO 3 (aq) cover near ambient temperatures 298 to 333 K and atmospheric pressure and were obtained by Ubbelohde and Ostwald type viscometer.…”

Section: Viscosity Measurementsmentioning

confidence: 99%

“…A literature survey revealed that the number of measurements [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] reported for the density of Na 2 CO 3 (aq) cover very limited ranges of temperature (up to 383 K) and pressure (up to 30 MPa). Shilovskaya and Lenkova [30] measured the density of Na 2 CO 3 (aq) in the temperature range from 293 to 353 K and for concentrations between 0.1 and 0.4 mol l −1 .…”

Section: Experiments Density Datamentioning

confidence: 99%

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Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures

Abdulagatov¹,

Azizov²,

Zeinalova³

2007

Zeitschrift Für Physikalische Chemie

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Apparent and Partial Molar Volumes / Density / B-Coefficient / Sodium Carbonate / Viscosity / WaterDensity of five (0.124, 0.334, 0.706, 1.055, and 1.123) mol kg −1 and viscosity of seven (0.124, 0.2918, 0.334, 0.706, 0.8472, 1.055, and 1.123) mol kg −1 binary aqueous Na 2 CO 3 solutions have been measured with a constant-volume piezometer and capillary flow techniques, respectively. Measurements were performed at pressures up to 52 MPa for the density and 40 MPa for the viscosity. The range of temperature was from 299 to 577 K for density and from 293 to 478 K for the viscosity. The total uncertainty of density, viscosity, pressure, temperature, and composition measurements was estimated to be less than 0.06%, 1.6%, 0.05%, 15 mK, and 0.02%, respectively. Apparent molar volumes were derived using measured values of density for the solutions and for pure water calculated with IAPWS formulation. The effect of the thermodynamic variables (temperature, pressure, and concentration) on density, apparent and partial molar volumes, and viscosity of Na 2 CO 3 (aq) solutions was studied. The derived apparent molar volumes have been interpreted in terms of the Pitzer's ion-interaction model of electrolyte solutions to accurate calculates the values of partial molar volumes at infinite dilution V ∞ 2 and the second (B V ) and third (C V ) virial coefficients for the apparent molar volume as a function of temperature. The viscosity data have been analyzed and interpreted in terms of extended Jones-Dole equation for the relative viscosity (η/η 0 ) of strong electrolyte solutions to accurate calculate the values of viscosity A-and B-coefficients as a function of temperature. The Arrhenius-Andrade parameters η A and b = E a /R (where E a is the flow activation energy) were calculated using present experimental viscosity data. The effective pressures P e due to the salt (Na 2 CO 3 ) in water in the TTG (Timmann-Tait-Gibson) model were calculated from present viscosity measurements.

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Section: Experiments Density Datamentioning

confidence: 98%

Section: Viscosity Measurementsmentioning

confidence: 99%

Section: Experiments Density Datamentioning

confidence: 99%

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Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures

Abdulagatov¹,

Azizov²,

Zeinalova³

2007

Zeitschrift Für Physikalische Chemie

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“…2-Quinoxalinecarbonitrile (2) was synthesized by oxidative ammonolysis of 2-methylquinoxaline by the literature method [3]. Anabasine was isolated from Anabasis aphylla as before [5].…”

Section: Methodsmentioning

confidence: 99%

“…In the first step, 2-quinoxalinecarbonitrile (2) was prepared in 50% yield from 2-methylquinoxaline by oxidative ammonolysis by the method developed by us previously [3]. Then, amidoxime 3 was synthesized in good yield from 2 by the action of NH 2 OH under mild conditions and was converted by diazotization with NaNO 2 in dilute HBr into hydroximoylbromide 4.…”

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confidence: 99%

Quinoxaline derivatives of severalalkaloids

Postnikov¹

2010

Chem Nat Compd

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New quinoxaline derivatives were prepared by reaction of 2-quinoxalinehydroximoylbromide with the alkaloids anabasine, cytisine, and salsoline.Quinoxaline derivatives, which exhibit a broad spectrum of biological activity, are some of the most synthesized of all classes of N-containing heterocyclic compounds [1]. The quinoxaline ring in nature is most often condensed into more complicated cyclic systems, the most well-known of which is riboflavin (vitamin B 2 ).Two quinoxaline drugs are currently widely used in medical practice. These are quinoxidine and dioxidine, which have significant chemotherapeutic activity and are used for acute bacterial infections that are difficultly treated by other antimicrobial agents [2].Our goal was to synthesize new quinoxaline derivatives containing fragments of several alkaloids of plant origin in their structure.The key compound in the synthesis of the alkaloid derivatives of quinoxaline-2-hydroxamic acid was 2-quinoxalinehydroximoylbromide, which was synthesized by successive transformations of 2-methylquinoxaline (1). In the first step, 2-quinoxalinecarbonitrile (2) was prepared in 50% yield from 2-methylquinoxaline by oxidative ammonolysis by the method developed by us previously [3]. Then, amidoxime 3 was synthesized in good yield from 2 by the action of NH 2 OH under mild conditions and was converted by diazotization with NaNO 2 in dilute HBr into hydroximoylbromide 4.The resulting bromo derivative could easily add primary and secondary amines with elimination of HBr. In our instance, the secondary amines were the alkaloids anabasine (5a), cytisine (5b), and salsoline (5c). The reaction between 4 and the alkaloids at the NH center occurred smoothly under mild conditions to produce the corresponding quinoxaline alkaloid derivatives 6-8.

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Cytotoxicity, tyrosine kinase inhibition of novel pyran, pyridine, thiophene, and imidazole derivatives

Azzam

Mohareb

Helal

et al. 2020

Journal of Heterocyclic Chem

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In this work, we are interested to use multicomponent reactions of cyclohexan‐1,3‐dione with different reagents for synthesizing new derivatives of pyran, pyridine, thiophene, and imidazole with antitumor activities. Twenty‐two newly synthesized derivatives were selected and tested for their anticancer potency. Several of these compounds exhibited quite interesting potencies toward three human tumor cell lines, namely NCI‐H460 (non‐small cell lung cancer), SF‐268 (CNS cancer), and MCF‐7 (breast adenocarcinoma), especially when compared to that of reference drugs, doxorubicin and 5‐Fu.Compounds 5b, 5c, 7b, 9b, 14a, 16c, 18a, 19c, 20b, and 22b, were found to be the most cytotoxic compounds toward the selected cell lines. On the other hand, 7b, 14a, 16c, 19c, and 22b revealed high inhibitions toward the tyrosine kinases. Active compounds against VEGFR‐2, 14a, 16c, and 19c, were docked inside VEGFR‐2enzyme to show the interaction between the tested compounds and the amino acids of the active site.

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Oxidative ammonolysis of 2-methylquinoxaline on vanadium-titanium oxide catalyst

Cited by 4 publications

References 2 publications

Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures

Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures

Quinoxaline derivatives of severalalkaloids

Cytotoxicity, tyrosine kinase inhibition of novel pyran, pyridine, thiophene, and imidazole derivatives

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Oxidative ammonolysis of 2-methylquinoxaline on vanadium-titanium oxide catalyst

Cited by 4 publications

References 2 publications

Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na2CO3Solutions at High Temperatures and High Pressures

Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na2CO3Solutions at High Temperatures and High Pressures

Quinoxaline derivatives of severalalkaloids

Cytotoxicity, tyrosine kinase inhibition of novel pyran, pyridine, thiophene, and imidazole derivatives

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Product

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Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures

Density, Apparent and Partial Molar Volumes, and Viscosity of Aqueous Na₂CO₃Solutions at High Temperatures and High Pressures