Oxidation-reduction potential studies: A new method in pharmacology principles, materials, and methods

Rouillon, Jean-Denis; Bernard, C.; Robert, Guy; Magnin, P

doi:10.1016/0160-5402(87)90029-5

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…The redox state of a biological system is kept within a narrow range under normal conditions-similar to the manner in which the biological system regulates its pH parameter. Under pathological conditions, the redox state can be changed toward lower (redosis) or higher (oxidosis) values (220,232). A 30-mV change in the redox status means a 10-fold change in the ratio between reductant and oxidant (202,217,220,256).…”

Section: Rooh (12)mentioning

confidence: 99%

Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

2002

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Reactive oxygen species (ROS) and other radicals are involved in a variety of biological phenomena , such as mutation, carcinogenesis , degenerative and other diseases, in ammation, aging, and development . ROS are well recognized for playing a dual role as deleterious and bene cial species. The objectives of this review are to describe oxidative stress phenomena , terminology, de nitions, and basic chemical characteristics of the species involved; examine the biological targets susceptible to oxidation and the defense mechanisms of the organism against these reactive metabolites; and analyze methodologies , including immunohistochemica l markers, used in toxicological pathology in the visualization of oxidative stress phenomena . Direct detection of ROS and other free radicals is dif cult, because these molecules are short-lived and highly reactive in a nonspeci c manner. Ongoing oxidative damage is, thus, generally analyzed by measuremen t of secondary products including derivatives of amino acids, nuclei acids, and lipid peroxidation . Attention has been focused on electrochemica l methods based on voltammetry measurements for evaluating the total reducing power of biological uids and tissues. This approach can function as a tool to assess the antioxidant-reducin g pro le of a biological site and follow changes in pathological situations. This review thus includes different topics essential for understanding oxidative stress phenomen a and provides tools for those intending to conduct study and research in this eld.

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Section: Rooh (12)mentioning

confidence: 99%

Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

2002

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“…Accumulating experimental evidence demonstrated that protein trafficking, synthesis, degradation and folding are also redox-sensitive processes [12]. The mechanisms responsible for regulating and maintaining the cellular redox homeostasis are not yet fully understood; however, it is widely accepted that alterations in this state toward lower (redosis) or higher (oxidosis) values might lead to several cellular deleterious processes [13, 14]. …”

Section: Reactive Oxygen Species and Oxidative Stressmentioning

confidence: 99%

NADPH Oxidase and Neurodegeneration

Hernandes

Britto²

2012

Current Neuropharmacology

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NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in the pathophysiology of several neurodegenerative diseases has been increasingly recognized. ROS produced by Nox proteins contribute to neurodegenerative diseases through distinct mechanisms, such as oxidation of DNA, proteins, lipids, amino acids and metals, in addition to activation of redox-sensitive signaling pathways. In this review, we discuss the recent literature on Nox involvement in neurodegeneration, focusing on Parkinson and Alzheimer diseases.

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“…Under normal conditions, the intracellular redox state, which implies the relative contribution of oxidation and reduction processes to the cell function, is constantly monitored and kept within a narrow range. The mechanisms responsible for regulating and maintaining the cellular redox homeostasis are not yet fully understood; however, it is widely accepted that alterations in this state toward lower (redosis) or higher (oxidosis) values might lead to several cellular deleterious processes [13,14]. Accumulating experimental evidence demonstrated that protein trafficking, synthesis, degradation and folding are also redox-sensitive processes [12].…”

Section: Reactive Oxygen Species and Oxidative Stressmentioning

confidence: 99%

NADPH Oxidase and Neurodegeneration

Hernandes¹,

Britto²

2012

Current Neuropharmacology

View full text Add to dashboard Cite

NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in the pathophysiology of several neurodegenerative diseases has been increasingly recognized. ROS produced by Nox proteins contribute to neurodegenerative diseases through distinct mechanisms, such as oxidation of DNA, proteins, lipids, amino acids and metals, in addition to activation of redoxsensitive signaling pathways. In this review, we discuss the recent literature on Nox involvement in neurodegeneration, focusing on Parkinson and Alzheimer diseases.

show abstract

Oxidation-reduction potential studies: A new method in pharmacology principles, materials, and methods

Cited by 9 publications

References 12 publications

Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

Invited Review: Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification

NADPH Oxidase and Neurodegeneration

NADPH Oxidase and Neurodegeneration

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