Synthesis of optically active natural carotenoids and structurally related compounds
VII. Synthesis of (3R)-3-hydroxyretinol, (3R)d-hydroxyretinal and (3R)-3-hydroxyretinoic acid
SummaryThe synthesis of (3R)-3-hydroxyretino1(7), (3R)-3-hydroxyretinal(9) and (3R)-3-hydroxyretinoic acid (5) according to the building principle C,, + C5 = C,, is reported utilizing the optically active C15-phosphonium salt 2 and the C,-aldehyde ester 3.