Oxidation of Proteins in the Lungs of Patients With Acute Respiratory Distress Syndrome

Lenz, AG; Jorens, P. G.; Meyer, Barbara J.; Backer, W. De; Overveld, F. Van; Bossaert, Leo; Maier, Konrad

doi:10.1097/00024382-199703001-00222

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2021

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“…Pathologies due to infection and / or inflammation such as pneumonia and ARDS constitute the majority of patients followed-up in intensive care units with the diagnosis of acute respiratory failure (18,19). It was shown with various studies that oxidative stress plays a role in the etiopathogenesis of these diseases (20)(21)(22). If acute respiratory failure is diagnosed early, adequate oxygenation can be achieved with non-invasive supportive treatments.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Dynamic Thiol Disulfide Homeostasis in Acute Respiratory Failure Patients in Intensive Care Unit

Apaydın¹,

Yıldız²,

Samim³

et al. 2021

eams

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Thiols are antioxidant agents which belong to mercaptan group consisting of sulfur and carbon containing sulfhydryl (-SH). Thiol levels, in the case of elevated oxidative stress, are lowered by their use in neutralization of reactive oxygen molecules. It was aimed to investigate thiol and disulfide blood levels or thiol/disulfide ratio as a marker of total oxidant status which plays a role in the pathogenesis of inflammatory diseases that may cause respiratory failure. The study included 98 patients (58 males, 40 females) who have partial oxygen pressure (PaO2)<60 mmHg or partial carbon dioxide pressure (PaCO2)>45 mmHg in arterial blood in intensive care unit and 98 healthy volunteers. Total thiol and native thiol levels were measured by spectrophotometric method.

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