Oxidation of one-carbon compounds to formate and carbon dioxide in rat liver mitochondria

Lewis, Katherine F.; Randolph, Verrell M.; Nemeth, E. M.; Frisell, Wilhelm R.

doi:10.1016/0003-9861(78)90187-x

Cited by 12 publications

(3 citation statements)

References 18 publications

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“…Lewis et al [18] radiolabeled the methyl group of SAM. Very little of the radioactivity appeared in metabolites of the folate and methionine cycles because most of these radiolabeled methyl groups were transferred to other substrates by the methylation reactions.…”

Section: Resultsmentioning

confidence: 99%

In silico experimentation with a model of hepatic mitochondrial folate metabolism

Nijhout

Reed

Lam

et al. 2006

Theor Biol Med Model

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The model reproduces many experimental findings and gives new insights into the underlying properties of mitochondrial folate metabolism. Particularly interesting is the remarkable stability of formate production in the mitochondria in the face of large changes in serine and glycine input. The model shows that in the presence of the bifunctional enzyme (as in embryonic tissues and cancer cells), the mitochondria primarily support cytosolic purine and pyrimidine synthesis via the export of formate, while in adult tissues the mitochondria produce serine for gluconeogenesis.

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Section: Resultsmentioning

confidence: 99%

In silico experimentation with a model of hepatic mitochondrial folate metabolism

Nijhout

Reed

Lam

et al. 2006

Theor Biol Med Model

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“…Folate-mediated one-carbon metabolism is involved in the synthesis of formyl-methionyl-tRNA for mitochondrial protein synthesis (Fig. 1, reaction 8) (46,47) and the oxidation of choline methyl groups via dimethylglycine dehydrogenase and sarcosine dehydrogenase (48). Mitochondrial C 1 -THF synthase may also play an important role in homocysteine metabolism.…”

Section: Discussionmentioning

confidence: 99%

Human Mitochondrial C1-Tetrahydrofolate Synthase

Prasannan

Pike

Peng

et al. 2003

Journal of Biological Chemistry

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C 1 -tetrahydrofolate (THF) synthase is a trifunctional enzyme found in eukaryotes that contains the activities 10-formyl-THF synthetase, 5,10-methenyl-THF cyclohydrolase, and 5,10-methylene-THF dehydrogenase. The cytoplasmic isozyme of C 1 -THF synthase is well characterized in a number of mammals, including humans; but a mitochondrial isozyme has been previously identified only in the yeast Saccharomyces.

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“…Serine, glycine, and formate have been identified as molecules that link the reactions occurring in the two compartments ( Cybulski and Fisher, 1977 ; Palmieri, 2004 ). Most of the one-carbon flow within mitochondria involves an oxidative process, leading to the production of formate from the single-carbon units obtained from these connector molecules ( Lewis et al, 1978 ). Hence, it is believed that the mitochondrial system serves as the main channel for creating glycine and single-carbon units, which are essential for cell division ( Barlowe and Appling, 1988 ; Desler et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

Bou Ghanem,

Hussayni,

Kadbey

et al. 2024

Front. Aging Neurosci.

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The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context of aging, OCM dysregulation can contribute to epigenetic modifications and aberrant redox states, accentuating cellular senescence and age-associated pathologies. Furthermore, OCM’s intricate involvement in cancer progression is evident through its capacity to provide essential one-carbon units crucial for nucleotide synthesis and DNA methylation, thereby fueling uncontrolled cell proliferation and tumor development. In neurodegenerative disorders like Alzheimer’s and Parkinson’s, perturbations in OCM pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. This review underscores the profound impact of OCM in diverse disease contexts, reinforcing the need for a comprehensive understanding of its molecular complexities to pave the way for targeted therapeutic interventions across inflammation, aging and neurodegenerative disorders.

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Oxidation of one-carbon compounds to formate and carbon dioxide in rat liver mitochondria

Cited by 12 publications

References 18 publications

In silico experimentation with a model of hepatic mitochondrial folate metabolism

In silico experimentation with a model of hepatic mitochondrial folate metabolism

Human Mitochondrial C1-Tetrahydrofolate Synthase

Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases

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