Oxidation of nitrite to nitrate in isolated erythrocytes: a possible mechanism for adaptation to environmental nitrite

Doblander, C.; Lackner, Reinhard

doi:10.1139/f96-254

Cited by 18 publications

(30 citation statements)

References 9 publications

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“…These fish were exposed to > 3.0 mg·l -1 N-NO 2 -for the preceding 2 weeks (NO 2 -/Cl -molar ratio approximately 0.26). The ability to adapt to the increased nitrite concentrations was reported by other authors including Doblander and Lackner (1997) and Máchová et al (2004).…”

Section: Discussionsupporting

confidence: 68%

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Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth

et al. 2008

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Voslářová E., V. Pištěková, Z. Svobodová, I. Bedáňová: Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth. Acta Vet. Brno 2008, 77: 455-460.The aim of this study was to investigate the long-term effects of subchronic exposure to sublethal levels of nitrite, ranging from 15 to 130 mg·l -1 NO 2 -, on growth in aquarium fish Danio rerio. The juvenile growth test according to OECD 215 was used in the experiments. Fish weight was measured at the beginning of the experiment and then using the same method, fish weight was observed 28 days after fish stocking. Compared to the control, growth suppression was detected from the concentration of 73 mg·l -1 NO 2 -(P < 0.05) and a significant inhibition of fish body growth was shown from 130 mg·l -1 NO 2 -(P < 0.01). An exponential relationship between nitrite concentrations and specific growth rate (R 2 = 0.896) was detected. Cyprinus rerio, zebrafish, NO 2 -, growth test

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Section: Discussionsupporting

confidence: 68%

“…Neither growth suppression nor tissue damage was observed (Wedemeyer and Yasutake 1978;Colt et al 1981). Acclimatisation of fish to elevated nitrite concentrations was studied by Tucker and Schwedler (1983), Doblander and Lackner (1997) and Máchová et al (2004).…”

Section: Cyprinus Rerio Zebrafish No 2 - Growth Testmentioning

confidence: 99%

Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth

et al. 2008

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“…The reaction of haem group proceeds via a series of intermediate reactions mediated by the radical NO • 2 , overall stoichiometry of the reaction being given by Kosaka and Tyuma (1987) Thus NO 2 -turnover by haemoglobin is followed by the production of NO 3 -, whereas methaemoglobin is eventually reduced to haemoglobin by methaemoglobin reductase. Other haem proteins of cells may react with nitrite in a similar way (Doblander and Lackner, 1997).…”

Section: Nitrite Uptake and Toxicity Mechanismsmentioning

confidence: 99%

“…A part of detoxification takes place in the liver, as revealed by the ability of trout hepatocytes to oxidise nitrite to nitrate (Doblander and Lackner, 1996). Attention was also paid to the capacity of erythrocytes to convert nitrite to nitrate (Doblander and Lackner, 1997). Oxygenated trout erythrocytes detoxify nitrite to nitrate whereas anoxic ones do not (Doblander and Lackner, 1997).…”

Section: Mechanism Of Detoxificationmentioning

confidence: 99%

Nitrite influence on fish: a review

Kroupová¹,

Máchová²,

Svobodová³

2005

Vet. Med.

194

117

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ABSTRACT:Nitrite is an intermediate in the oxidation of ammonium to nitrate. An elevated ambient nitrite concentration is a potential problem for freshwater fish since nitrite is actively taken up across the gills in competition with chloride. Nitrite is a well-known toxicant for fish as well as a disrupter of multiple physiological functions including ion regulatory, respiratory, cardiovascular, endocrine and excretory processes. One critical consequence of nitrite accumulation is the oxidation of haemoglobin to methaemoglobin, compromising blood oxygen transport. Nitrite toxicity to fish varies considerably and depends on a large number of external and internal factors. Among the most important ones are water quality (e.g. pH, temperature, cation, anion and oxygen concentration), length of exposure, fish species, fish size and age, and individual fish susceptibility. Chloride concentration in water is considered one of the most important factors influencing nitrite toxicity to fish. The importance of individual factors is assessed and re-evaluated continuously.

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“…According to Doblander and Lackner (1997) part of the nitrite taken up will be detoxified by erythrocytes in fish.…”

Section: Higher Organismsmentioning

confidence: 99%

Origin, causes and effects of increased nitrite concentrations in aquatic environments

Philips

Laanbroek

Verstraete

2002

Rev Environ Sci Biotechnol

312

198

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Literature frequently mentions increased nitrite concentrations along with its inhibitory effect towards bacteria and aquatic life. Nitrite accumulation has been studied for decades, and although numerous causal factors have already been commented on in literature, the mechanism of nitrite accumulation is not always clear. From the broad range of parameters and environmental factors reviewed in this paper, it is obvious that the causes and consequences of nitrite accumulation are not yet completely understood. Among others, pH, dissolved oxygen, volatile fatty acids, phosphate and reactor operation have been found to play a role in nitrite accumulation, which results from differential inhibition or disruption of the linkage of the different steps in both nitrification and denitrification. In the case of nitrification, this differential inhibition could lead to the displacement or unlinking of the ammonia oxidisers and nitrite oxidisers. In this paper, the idea is formulated that the nitrifier population forms a role model for the total microbial community. Increased nitrite concentrations would in this aspect not only signal a disruption of nitrifiers, but possibly also of the total configuration of the microbial community.Abbreviations: AMO -Ammonia mono-oxygenase; Anammox -Anaerobic ammonium oxidation; AOBAmmonia-oxidising bacteria; ATP -Adenosine triphosphate; COD -Chemical oxygen demand; DNRA -Dissimilatory nitrate reduction to ammonium; DO -Dissolved oxygen; EU -European union; FA -Free ammonia; F/M -Food to micro-organism ratio; FNA -Free nitrous acid; HAO -Hydroxylamine oxidoreductase; HRTHydraulic residence time; NDBEPR -Enhanced biological phosphate removal with nitrification and denitrification; NO -Nitric oxide; NOB -Nitrite-oxidising bacteria; NOR -Nitrite oxidoreductase; OLAND -Oxygen limited autotrophic nitrification denitrification; RBC -Rotating biological contactor; Sharon -Single reactor high activity ammonia removal over nitrite; SRT -Sludge residence time; TAN -Total ammoniacal nitrogen; TOC -Total organic carbon; VAS -Volatile attached solids

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Oxidation of nitrite to nitrate in isolated erythrocytes: a possible mechanism for adaptation to environmental nitrite

Cited by 18 publications

References 9 publications

Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth

Nitrite Toxicity to Danio rerio: Effects of Subchronic Exposure on Fish Growth

Nitrite influence on fish: a review

Origin, causes and effects of increased nitrite concentrations in aquatic environments

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