Oxidation of Hydrocarbons in Basic Solution

Selective Chemical Oxidation of Risperidone: A Straightforward and Cost‐Effective Synthesis of Paliperidone

“…Identification of the impurities allowed us to draw a possible mechanism for this reaction (Scheme 3). [21] Among the five possible benzylic positions, it is likely that two are more easily deprotonated thanks to possible resonance stabilization, that is, at C-9 and the methyl group. The preferential hydroxylation at C-9 indicates that deprotonation at C-9 to give 17 is favored.…”

The Quest for Quinine: Those Who Won the Battles and Those Who Won the War

“…Dimethyl sulfoxide was employed to reduce in situ the intermediate hydroperoxides formed. [151] From an industrial viewpoint, the synthesis was considered satisfactory when the comparatively higher commercial value of quinidine with respect to quinine was taken into account. The autooxidation was an efficient transformation and its fortuitous stereochemical result constituted a remarkable step forward.…”

Thermodynamic properties and Mechanism of Aquachloro iridium (III) Catalyzed Oxidation of Pharmaceutical drug (Paracetamol) by Acidic solution of Potassium Bromate (KBrO3): A kinetic study

“…[45][46][47] Oxidation reactions are important in the synthesis of organic compounds, create new functional groups or modify existing functional groups in a molecule. [48][49] Various advanced oxidation processes such as electrochemical [50][51][52] ozonation and H2O2 / UV oxidation [53][54][55][56] have been employed to remove aqueous paracetamol. The present study examines, in detail the kinetic and mechanistic aspects of the Ir(III) catalyzed oxidation of paracetamol by KBrO 3 in acidic media with the following objective.…”