Dehydrogenation of propane in the presence and absence of CO 2 over CrO x /SiO 2 and CrO x /Al 2 O 3 catalysts with Cr loading between 0.7-20.4 wt% was discussed. It was found that the nature of support strongly effects on the catalytic performance in the dehydrogenation with CO 2 . Over the CrO x /SiO 2 catalyst CO 2 enhance the propene yield, whereas over the CrO x /Al 2 O 3 catalyst the yield and selectivity of propene in the presence of CO 2 strongly decrease. The effect of steam on catalytic performance of the tested catalysts was also discussed.