Oxidation of glyceraldehyde-3-phosphate dehydrogenase decreases sperm motility in diabetes mellitus

Peach gum polysaccharides improve the spermatogenesis of KKAy mice with impaired reproduction system

“…[3][4][5][6][7][8] Values are expressed as mean±SD (n=3). DM impairs sperm parameters and decreases the serum testosterone levels.…”

“…DM impairs sperm parameters and decreases the serum testosterone levels. [3][4][5][6][7][8] Intragastric treatment with PGPs significantly improved the density, movement, and rate of normal morphology of sperm of KKAy mice compared with those in the control group (P<.05; Table 3). Previous studies reported that other polysaccharides protect the reproductive function of the male animal and prevent spermatogenic cell apoptosis; these polysaccharides include those derived from Lycium barbarum, 15,16 Portulace oleracea, 17 and Laminaria japonica.…”

“…1 More than 90% of diabetic patients are diagnosed as non-insulin-dependent (type 2 DM), which is characterized by hyperglycemia and dyslipidemia caused by the defects of either insulin secretion or action. [3][4][5][6][7][8] Talebi et al 6 reported that vitamin C attenuated the detrimental effects of DM on sperm parameters, chromatin quality, and rate of apoptosis in mice; Gonzales et al 7 found that the mixture of extracts from Peruvian plants (black maca and yacon) improved sperm count and reduced glycemia in mice with streptozotocininduced diabetes. [3][4][5][6][7][8] Talebi et al 6 reported that vitamin C attenuated the detrimental effects of DM on sperm parameters, chromatin quality, and rate of apoptosis in mice; Gonzales et al 7 found that the mixture of extracts from Peruvian plants (black maca and yacon) improved sperm count and reduced glycemia in mice with streptozotocininduced diabetes.…”

“…2 Many studies reported that DM impaired sperm parameters and decreased testosterone serum levels. [3][4][5][6][7][8] Talebi et al 6 reported that vitamin C attenuated the detrimental effects of DM on sperm parameters, chromatin quality, and rate of apoptosis in mice; Gonzales et al 7 found that the mixture of extracts from Peruvian plants (black maca and yacon) improved sperm count and reduced glycemia in mice with streptozotocininduced diabetes.…”

Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?

“…In 2013, the number of diabetics was 3.82 millions in the world. By 2035, it has been estimated that the number of people who suffer from diabetes would reach 5.92 million [1]. …”