Oxidation of Flavin by Molecular Oxygen: Computational Insights into a Possible Radical Mechanism
Jernej Stare
Abstract:As a highly electrophilic moiety capable of oxidizing
a variety
of small organic molecules and biomolecules, flavin is an important
prosthetic group in many enzymes. Upon oxidation of the substrate,
flavin is converted into its reduced (dihydrogenated) form. The catalytic
cycle is completed through oxidation back to the oxidized form, thus
restoring the enzyme’s oxidizing capability. While it has been
firmly established that oxidation of the reduced form of flavin is
cast by molecular oxygen, yielding oxidized… Show more
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