“…Therefore, considerable efforts have been made in the development of both symmetric-and antisymmetric thiosulfonates. 3 Among, the most frequently employed method for the synthesis of symmetric thiosulfonates involve the direct oxidation of disulfides in the presence of various promoting reagents such as ceric ammonium nitrate/iodine, 4 chlorine/acetic anhydride, 5 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), 6 dibromo hydantoin, 7 dinitrogen tetroxide/charcoal, 8 dinitrogen tetroxide supported on poly(vinylpyrrolidone), 9 dichlorodioxomolybdenum, 10 1-fluoro-2,4,6-trimethylpyridinium trifloromethanesulfonate, 11 hydrogen peroxide/titanium tetrachloride, 12 3-chloroperbenzoic acid, 13 N-bromophthalimide, 7 N-bromosuccinimide, 14 N-chlorophthalimide, 7 Nchlorosuccinimide, 11 scandium tris(trifluoromethanesulfonate), 15 silica sulfuric acid/sodium nitrite, 16 sodium periodate 17 and zinc dichromate trihydrate. 18 However, many of these methods have their own merits and demerits including long reaction times, drastic reaction conditions, use of volatile and toxic organic solvents, undesirable side reactions, laborious workup procedures, usage of expensive reagents, special treatment for the activation of the reagent and unsatisfactory yields.…”