Oxidation of cyclohexane with molecular oxygen in presence of characterized macrocyclic heteronuclear FeCu complex catalyst ionically bonded to zirconium pillared montmorillonite clay

Anisia, K.S.; Kumar, Anil

doi:10.1016/j.molcata.2007.02.045

Cited by 28 publications

(10 citation statements)

References 44 publications

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“…In our earlier work (Anisia and Kumar, 2007) oxidation of cyclohexane was carried out using Fe–Cu complex catalyst. This gave very low rate of reaction but highly specific to the formation of cyclohexanone.…”

Section: Resultsmentioning

confidence: 99%

“…Tolman et al (1989), Spielman (1964), and Alagy et al (1974) developed a reaction scheme consisting of 154 reactions which is impractical to analyze as it requires the determination of as many number of rate constants simultaneously with high accuracy. Hence lumped kinetic models which require lesser rate constants (Gange et al, 1981; Pohorecki et al, 1992, 2001; Ponec, 2001; Anisia and Kumar, 2007) are useful in analyzing reaction data.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits

Wise

Turner

Kerr

2007

Birth Defects Research Pt B

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BACKGROUND:The developmental toxicity potential of vorinostat (suberoylanilide hydroxamic acid [SAHA], ZOLINZAt), a potent inhibitor of histone deacetylase (HDAC), was assessed in Sprague-Dawley rats and Dutch Belted rabbits. HDAC inhibitors have been shown to mediate the regulation of gene expression, induce cell growth, cell differentiation, and apoptosis of tumor cells. Range-finding studies established oral dose levels of 5, 15, or 50 mg/kg/ day and 20, 50, or 150 mg/kg/day in rats and rabbits, respectively. METHODS: Animals were dosed on Gestation Days 6-20 or 7-20, respectively, with litter/fetal parameters evaluated on GD 21 and 28, respectively. Separate studies evaluated toxicokinetic parameters at the mid-and high-dose levels. RESULTS: There was no maternal toxicity observed at the highest dose levels; however, hematology and serum biochemistry changes were characterized in the rangefinding studies. Vorinostat did not induce morphological malformations in either rat or rabbit fetuses. In rats, drugrelated developmental toxicity was observed only in the high-dose group and consisted of markedly decreased fetal weight and increases in fetuses with a limited number of skeletal variations. In rabbits, drug-related developmental toxicity was also observed only in the high-dose group and consisted of slightly decreased fetal weight and increases in fetuses with a short 13th rib and incomplete ossification of metacarpals. Maternal exposures to vorinostat based on AUC and Cmax values were comparable at the high-dose levels of both species. Rabbits tolerated higher dosages probably due to more extensive metabolism. Maternal concentrations of vorinostat were B1,000-fold above the known in vitro HDAC inhibitory concentration. CONCLUSIONS: Review of previous work with valproic acid, another HDAC inhibitor, suggest that the developmental toxicity profiles of these 2 compounds are not the result of HDAC inhibition but involve other mechanisms. Birth Defects Res (Part B) 80: 57-68, 2007. r 2007

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits

Wise

Turner

Kerr

2007

Birth Defects Research Pt B

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“…In our earlier work (Anisia and Kumar, 2007) oxidation of cyclohexane was carried out using Fe-Cu complex catalyst. This gave very low rate of reaction but highly specific to the formation of cyclohexanone.…”

Section: Resultsmentioning

confidence: 99%

“…, 1981;Pohorecki et al, 1992Pohorecki et al, , 2001Ponec, 2001;Anisia and Kumar, 2007) are useful in analyzing reaction data. In our present work, a macrocyclic binuclear monometallic copper complex has been synthesized and is ionically bonded to the zirconium pillared montmorillonite clay through ion exchange.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of heterogeneous copper complex catalyst for oxidation of cyclohexane using molecular oxygen

Anisia

Kumar

2008

Can J Chem Eng

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Binuclear macrocyclic copper complex was synthesized and bonded ionically to the montmorillonite clay to enhance thermal stability upto 600 • C. The oxidation of cyclohexane using molecular oxygen in the absence of initiators, promoters and coreactants has been studied in the temperature range 145-190 • C. The overall cyclohexane conversion was 21% at 180 • C and cyclohexanone, the major product with 71% selectivity. The experimental data were analyzed against kinetic scheme proposed and the rate constants determined using Genetic Algorithm.

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“…In this study, at first the deviation atoms on the 1-and 4-position of cyclohexane and its derivatives from chair plane in chair conformation were investigated, because the deviation of these atoms in two positions may affect the rate of reaction of cyclohexane and its derivatives and may impact the region of NMR signal of 1-and 4-posion of cyclohexane [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Computational evaluation concerning the deviation of the atoms in 1- and 4-postions on the six-member ring and the effects on 1HNMR chemical shift

et al. 2011

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Density functional theory (DFT) calculations were carried out on some cyclohexane derivatives to investigate the deviation atoms on the 1-and 4-positions of chair plane. The deviations of chair plane of two position in the cyclohexane derivatives were calculated at the B3LYP/6-31 ++ G(d,p) level. Furthermore, we investigated the correlation between deviations of two positions from chair plane on the chemical shift hydrogen atoms on the 4-position.

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Oxidation of cyclohexane with molecular oxygen in presence of characterized macrocyclic heteronuclear FeCu complex catalyst ionically bonded to zirconium pillared montmorillonite clay

Cited by 28 publications

References 44 publications

Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits

Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits

Synthesis of heterogeneous copper complex catalyst for oxidation of cyclohexane using molecular oxygen

Computational evaluation concerning the deviation of the atoms in 1- and 4-postions on the six-member ring and the effects on 1HNMR chemical shift

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