Oxidation of Benzylic Alcohols and Ethers to Carbonyl Derivatives by Nitric Acid in Dichloromethane.

Abstract

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One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles

“…Because the oxidation of benzyl alcohols and benzyl methyl ethers to the corresponding aldehydes is common, 16 − 18 we envisioned that benzyl alcohols and benzyl methyl ethers might be used directly instead of aldehydes ( Scheme 1 D).…”

Synthesis of hydroxy benzoin/benzil analogs and investigation of their antioxidant, antimicrobial, enzyme inhibition, and cytotoxic activities

“…organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide then following reactions leading to an efficient synthesis of benzil compounds [24]. Facile oxidation of benzylic alcohols and benzoin to give benzil compounds with various oxidation reagents had been reported [24][25][26][27][28][29][30][31][32].…”

Vicarious Nucleophilic Chloromethylation of Nitroaromatics

“…For example, electrophilic aromatic nitration of benzylic chlorides uses harsh conditions and often leads to a regioisomeric mixture of products. 6,7 In this context, we have proposed a new synthetic strategy leading to selectively substituted o-nitrobenzyl chlorides by nucleophilic aromatic substitution of hydrogen of nitrobenzenes via the vicarious nucleophilic substitution (VNS) process. 8,9 Direct nucleophilic aromatic chloromethylation has not been achieved, but there are several reports in the literature of VNS leading to nitrosubstituted benzylic products.…”