Oxidation and sensing of ascorbic acid and dopamine on self-assembled gold nanoparticles incorporated within polyaniline film

Chu, Wenya; Zhou, Qun; Li, Shuangshuang; Zhao, Wei; Li, Na; Zheng, Junwei

doi:10.1016/j.apsusc.2015.06.141

Cited by 39 publications

(5 citation statements)

References 32 publications

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“…For this purpose, this sensor was exposed to a variety of potential interfering compounds and biomolecules, frequently found in biological samples, such as ascorbic acid (L-AA), biotin, and fibrinogen from human plasma. The first two com-pounds are electroactive ones at the presence of AuNPs [41,42], whereas fibrinogen is not electroactive but, as a protein, is potentially capable of adsorbing on the surface of AuNPs [43], diminishing their activity with respect to H 2 O 2 , and changing, thus, the amperometric signal.…”

Section: Electrochemistrymentioning

confidence: 99%

Gold Nanoparticle-Loaded Porous Poly(ethylene glycol) Nanosheets for Electrochemical Detection of H2O2

Zhao,

Zharnikov

2023

Nanomaterials

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The effective detection of hydrogen peroxide (H2O2) in different environments and, above all, in biological media, is an important practical issue. To this end, we designed a novel electrochemical sensor for H2O2 detection by introducing gold nanoparticles (AuNPs) into the porous poly(ethylene glycol) (PEG) matrix formed by the thermally activated crosslinking of amino- and epoxy-decorated STAR-PEG precursors. The respective composite PEG-AuNP films could be readily prepared on oxidized Si substrates, separated from them as free-standing nanosheets, and transferred as H2O2 sensing elements onto the working electrode of the electrochemical cell, with the performance of the sensing element relied on the established catalytic activity of AuNPs with respect to H2O2 decomposition. The sensitivity, detection limit, and the operation range of the composite PEG-AuNP sensors were estimated at ~3.4 × 102 μA mM−1 cm−2, 0.17 μM of H2O2, and 20 μM–3.5 mM of H2O2, respectively, which are well comparable with the best values for other types of H2O2 sensors reported recently in literature. The particular advantages of the composite PEG-AuNP sensors are commercial source materials, a simple fabrication procedure, the bioinert character of the PEG matrix, the 3D character of the AuNP assembly, and the possibility of transferring the nanosheet sensing element to any secondary substrate, including the glassy carbon electrode of the electrochemical cell. In particular, the bioinert character of the PEG matrix can be of importance for potential biological and biomedical applications of the designed sensing platform.

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Section: Electrochemistrymentioning

confidence: 99%

Gold Nanoparticle-Loaded Porous Poly(ethylene glycol) Nanosheets for Electrochemical Detection of H2O2

Zhao,

Zharnikov

2023

Nanomaterials

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“…The effective anchoring of the biomolecules on the ITO substrate surface is a significant point to develop a successful biosensor. Therefore, several modification strategies such as physical adsorption [12], electrophoretic deposition [13][14][15], electrochemical deposition [16,17], silanization [18,19], self-assembled monolayer formation [20] and electro-polymerization [21][22][23] have been employed to develop ITO based biosensor. ITO substrates have been modified with different silane agents such as 3-isocyanatopropyl triethoxysilane (IPTES) [24], 3-aminopropyltriethoxy silane (APTES) [25][26][27], 11-cyanoundecyltrimethoxysilane (11-CUTMS) [28], (3-glycidoxypropyl)trimethoxysilane [29], N-(2-aminoethyl)-3aminopropyltrimethoxysilane [18], 3-mercaptopropyl trimethoxysilane (3-MPTMS) [30], 3-glycidoxy propyldimethoxysilane [19], 11-(triethoxysilyl)undecanal (TESU) [31], carboxyethylsilanetriol (CTES) [32].…”

Section: Introductionmentioning

confidence: 99%

A sensitive and label-free electrochemical impedance immunosensor for CDH 22 biomarker detection based on organo-functional silane modified ITO electrode

Aydın

2019

Hacettepe Journal of Biology and Chemistry

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B u çalışmada, anti-CDH 22 antikoru ve CDH 22 antijeni arasındaki spesifik immüno-reaksiyona dayanan, kadherin benzeri protein (CDH 22) biyobelirtecinin tespiti için yeni bir elektrokimyasal etiketsiz immünosensör üretilmiştir. Geliştirilen immünosensör, anti-CDH 22 antikorlarının 3-siyanopropiltrimetoksisilan (CPTMS) ile modifiye edilmiş ITO substratı üzerinde immobilizasyonu ile oluşturulmuştur. Anti-CDH 22 antikorlarının CPTMS silanizasyon ajanına etkili bağlanması, morfolojik karakterizasyon (Taramalı Elektron Mikroskobu (SEM), Atomik Kuvvet Mikroskobu (AFM)) ve elektrokimyasal karakterizasyon (Elektrokimyasal İmpedans Spektroskopisi (EIS), Siklik Voltammetri (CV) kullanılarak incelendi. Optimum deney koşulları altında, ITO / CPTMS ile modifiye edilmiş elektrot, anti-CDH 22 antikor bağlanması için iyi bir bağlayıcıydır. Ek olarak, CPTMS modifiye elektrot CDH 22 antijen tespiti için etkili bir yüzey sunmuştur. İmmünosensör, geniş bir lineer tespit aralığı (0.03-3 pg/mL) ile düşük tespit limiti (9 fg/mL) ile sahipti. Ayrıca, iyi tekrarlanabilirlik, mükemmel tekrarlanabilirlik ve uzun depolama kararlılığına sahipti. Ek olarak, önerilen immünosensörün pratik uygulanabilirliği, insan serum numuneleri kullanılarak araştırıldı. İnsan serum numuneleri geri kazanım sonuçları (% 99.16-% 101.94) önerilen biyosensörün doğruluğunu göstermektedir. Sonuç olarak, CPTMS, biyosensör yapımı için umut verici bir platform olabilir ve bu önerilen immünosensör gerçek insan serum analizi için uygulanabilir. Anahtar Kelimeler Kadherin benzeri protein, elektrokimyasal impedans spektroskopisi, tek kullanımlık elektrot.

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“…(12)(13)(14) Another important factor for developing in vivo DA electrochemical sensors is the sensitivity. Because the sensitivity of an electrochemical sensor is directly related to the electrode surface area and conductivity, a variety of nanostructured materials, such as metal oxide nanoparticles, (15)(16)(17) carbon nanotubes, (18,19) metal or bimetallic nanoparticles, (20)(21)(22)(23) graphene, (24)(25)(26) and nanocomposites, (27,28) have been proposed to modify the electrode.…”

Section: Introductionmentioning

confidence: 99%

Microelectrode Arrays Modified with Nafion/Nanoporous AuPt Nanoparticles for in vivo Detection of Dopamine

2018

Sensors and Materials

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Electrochemical determination using implantable microelectrode arrays provides a powerful tool for recording neurotransmitter concentrations across multiple spatial locations of brain tissue. In this study, nanoporous AuPt alloy nanoparticles with very rough surfaces and Nafion film were sequentially electrodeposited on Michigan-type microelectrode arrays to improve sensitivity and selectivity to dopamine (DA). The modified microelectrode arrays were characterized by scanning electron microscopy (SEM), X-ray diffractometry, cyclic voltammetry (CV), and amperometry. The results of SEM experiments indicated that the obtained AuPt alloy nanoparticles with many different sizes of pores possessed very rough surfaces and exhibited cauliflower-like shapes. During amperometric measurements, the constructed DA sensors showed a wide linear range of 0.05-12.05 μM with a high sensitivity of 73.4 ± 3.1 pA/μM. Other important features include a low detection limit of 25 nM (signalto-noise ratio: 3), excellent selectivity over ascorbic acid (AA), and good stability. The feasibility of in vivo DA detection using the modified microelectrode arrays was verified by recording electrically evoked DA in the striatum of rats. The developed DA sensors based on microelectrode arrays provide an important tool for electrochemical detection of in vivo DA.

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Oxidation and sensing of ascorbic acid and dopamine on self-assembled gold nanoparticles incorporated within polyaniline film

Cited by 39 publications

References 32 publications

Gold Nanoparticle-Loaded Porous Poly(ethylene glycol) Nanosheets for Electrochemical Detection of H2O2

Gold Nanoparticle-Loaded Porous Poly(ethylene glycol) Nanosheets for Electrochemical Detection of H2O2

A sensitive and label-free electrochemical impedance immunosensor for CDH 22 biomarker detection based on organo-functional silane modified ITO electrode

Microelectrode Arrays Modified with Nafion/Nanoporous AuPt Nanoparticles for in vivo Detection of Dopamine

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